A novel function of Prohibitin on melanosome transport in melanocytes.
Melanophilin
Prohibitin
Rab27a
melanosome transport
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
10
2019
accepted:
13
02
2020
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
19
5
2021
Statut:
epublish
Résumé
Prohibitin (PHB, also known as PHB1 or BAP32), is a highly conserved 31kDa protein that expressed in many cellular compartments, such as mitochondria, nucleus, cytosol, and plasma membrane, and plays roles in regulating the transcription of genes, apoptosis, and mitochondrial biogenesis. There is a report that Prohibitin expression is required for the stimulation of pigmentation by melanogenin. However, no studies have been published on the function of PHB in melanocytes, especially in melanosome transport.
Identifiants
pubmed: 32226526
doi: 10.7150/thno.41383
pii: thnov10p3880
pmc: PMC7086355
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Melanins
0
Mlph protein, mouse
0
Prohibitins
0
Repressor Proteins
0
rab27 GTP-Binding Proteins
0
Rab27a protein, mouse
EC 3.6.1.-.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3880-3891Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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