Post-transplantation lymphoproliferative disorders: Current concepts and future therapeutic approaches.
Epstein-Barr virus
Future therapies
Hematopoietic stem cell transplant
Lymphoproliferative disorders
Post-transplant lymphoproliferative disorder prevention
Solid organ transplant
Journal
World journal of transplantation
ISSN: 2220-3230
Titre abrégé: World J Transplant
Pays: United States
ID NLM: 101608356
Informations de publication
Date de publication:
28 Feb 2020
28 Feb 2020
Historique:
received:
17
09
2019
revised:
21
10
2019
accepted:
13
12
2019
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
1
4
2020
Statut:
ppublish
Résumé
Transplant recipients are vulnerable to a higher risk of malignancy after solid organ transplantation and allogeneic hematopoietic stem-cell transplant. Post-transplant lymphoproliferative disorders (PTLD) include a wide spectrum of diseases ranging from benign proliferation of lymphoid tissues to frank malignancy with aggressive behavior. Two main risk factors of PTLD are: Firstly, the cumulative immunosuppressive burden, and secondly, the oncogenic impact of the Epstein-Barr virus. The latter is a key pathognomonic driver of PTLD evolution. Over the last two decades, a considerable progress has been made in diagnosis and therapy of PTLD. The treatment of PTLD includes reduction of immunosuppression, rituximab therapy, either isolated or in combination with other chemotherapeutic agents, adoptive therapy, surgical intervention, antiviral therapy and radiotherapy. In this review we shall discuss the prevalence, clinical clues, prophylactic measures as well as the current and future therapeutic strategies of this devastating disorder.
Identifiants
pubmed: 32226769
doi: 10.5500/wjt.v10.i2.29
pmc: PMC7093305
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
29-46Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: No conflict of interest.
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