The Scrapie Prevalence in a Goat Herd Is Underestimated by Using a Rapid Diagnostic Test.

ELISA classical scrapie clinical diagnosis goat immunohistochemistry prion transmissible spongiform encephalopathy

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2020
Historique:
received: 17 12 2019
accepted: 18 02 2020
entrez: 1 4 2020
pubmed: 1 4 2020
medline: 1 4 2020
Statut: epublish

Résumé

Current European surveillance regulations for scrapie, a naturally occurring transmissible spongiform encephalopathy (TSE) or prion disease in sheep and goats, require testing of fallen stock or healthy slaughter animals, and outline measures in the case of confirmation of disease. An outbreak of classical scrapie in a herd with 2500 goats led to the culling of the whole herd, providing the opportunity to examine a subset of goats, take samples, and examine them for the presence of disease-associated prion protein (PrP

Identifiants

pubmed: 32226784
doi: 10.3389/fbioe.2020.00164
pmc: PMC7081731
doi:

Types de publication

Journal Article

Langues

eng

Pagination

164

Informations de copyright

Crown Copyright © 2020 APHA. Konold, Spiropoulos, Thorne, Phelan, Fothergill, Rajanayagam, Floyd, Vidana, Charnley, Coates and Simmons.

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Auteurs

Timm Konold (T)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

John Spiropoulos (J)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Jemma Thorne (J)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Laura Phelan (L)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Louise Fothergill (L)

Central Sequencing Unit, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Brenda Rajanayagam (B)

Department of Epidemiological Sciences, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Tobias Floyd (T)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Beatriz Vidana (B)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Judith Charnley (J)

Animal and Plant Health England Field Delivery, Skipton, United Kingdom.

Nadya Coates (N)

TSE/BVDV Testing Laboratory, Eurofins Forensic Services, Risley, United Kingdom.

Marion Simmons (M)

Pathology Department, Animal and Plant Health Agency Weybridge, Addlestone, United Kingdom.

Classifications MeSH