QTC-4-MeOBnE Rescues Scopolamine-Induced Memory Deficits in Mice by Targeting Oxidative Stress, Neuronal Plasticity, and Apoptosis.

Acetylcholinesterase / metabolism Animals Apoptosis Hippocampus / metabolism Maze Learning Memory Disorders / chemically induced Mice Neuronal Plasticity Oxidative Stress Scopolamine / toxicity
Alzheimer’s disease acetylcholinesterase apoptosis glycogen synthase kinase multitarget directed ligand oxidative damage

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
06 05 2020
Historique:
pubmed: 2 4 2020
medline: 22 6 2021
entrez: 2 4 2020
Statut: ppublish

Résumé

Cognitive decline and memory impairment induced by disruption of cholinergic neurons and oxidative brain damage are among the earliest pathological hallmark signatures of Alzheimer's disease. Scopolamine is a postsynaptic muscarinic receptor blocker which causes impairment of cholinergic transmission resulting in cognitive deficits. Herein we investigated the effect of QTC-4-MeOBnE (1-(7-chloroquinolin-4-yl)-

Identifiants

DOI: 10.1021/acschemneuro.9b00661 PMID: 32227985
pubmed: 32227985
doi: 10.1021/acschemneuro.9b00661
doi:

Substances chimiques

Scopolamine DL48G20X8X
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1259-1269

Auteurs

Mariana G Fronza (MG)

Neurobiotechnology Research Group - GPN, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.

Rodolfo Baldinotti (R)

Neurobiotechnology Research Group - GPN, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.

Jenifer Fetter (J)

Neurobiotechnology Research Group - GPN, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.

Manoela Sacramento (M)

Laboratory of Clean Organic Synthesis - LASOL, Federal University of Pelotas - UFPel, Chemical, Pharmaceutical and Food Science Center, Pelotas, RS 96160-000, Brazil.

Fernanda Severo Sabedra Sousa (FSS)

Oncology Research Group - GPO, CDTec, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.

Fabiana K Seixas (FK)

Oncology Research Group - GPO, CDTec, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.

Tiago Collares (T)

Oncology Research Group - GPO, CDTec, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.

Diego Alves (D)

Laboratory of Clean Organic Synthesis - LASOL, Federal University of Pelotas - UFPel, Chemical, Pharmaceutical and Food Science Center, Pelotas, RS 96160-000, Brazil.

Domenico Praticò (D)

Alzheimer's Center at Temple - ACT, Temple University, Lewis Katz School of Medicine, Philadelphia, Pennsylvania 19140, United States.

Lucielli Savegnago (L)

Neurobiotechnology Research Group - GPN, Federal University of Pelotas - UFPel, Technological Development Center, Pelotas, RS 96160-000, Brazil.
ORCID: 0000-0003-0494-5610

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Eucaryotes › Animaux › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › QTC-4-MeOBnE Rescues Scopolamine-Induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Tropanes › Dérivés de la scopolamine › Scopolamine › QTC-4-MeOBnE Rescues Scopolamine-Induced...