Severity assessment using three common behavioral or locomotor tests after laparotomy in rats: a pilot study.

Animals Behavior Rating Scale Laparotomy / adverse effects Locomotion Male Pilot Projects Rats Rats, Wistar
distress behavior motor activity physiology rat severity assessment surgical techniques

Journal

Laboratory animals
ISSN: 1758-1117
Titre abrégé: Lab Anim
Pays: England
ID NLM: 0112725

Informations de publication

Date de publication:
Dec 2020
Historique:
pubmed: 2 4 2020
medline: 29 6 2021
entrez: 2 4 2020
Statut: ppublish

Résumé

The aim of this pilot study was to evaluate whether behavioral or locomotor tests (Open Field (OF), rotarod (RR), and CatWalk (CW)) can help assess the severity of laparotomy in rats.The new EU Directive (2010/63/EU) mandates severity assessment in experiments involving animals. However, validated and objective methods are needed to relate trial-specific monitoring results to the degree of distress caused to individual animals. Therefore, we focused on non-invasive or minimally invasive, simple, and convenient severity assessment methods in a surgical model.To evaluate surgical severity in this model, we compared moving velocity among three commonly used behavioral test methods (OF, RR, and CW) after midline laparotomy within postoperative 7 days.In this study, 30 adult male Wistar Han rats (

Identifiants

DOI: 10.1177/0023677220911680 PMID: 32228147
pubmed: 32228147
doi: 10.1177/0023677220911680
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

525-535

Commentaires et corrections

Type : ErratumIn

Auteurs

Leonie Zieglowski (L)

Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen University, Faculty of Medicine, Germany.

Anna Kümmecke (A)

Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen University, Faculty of Medicine, Germany.

Lisa Ernst (L)

Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen University, Faculty of Medicine, Germany.

Mareike Schulz (M)

Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen University, Faculty of Medicine, Germany.

Steven R Talbot (SR)

Institute for Laboratory Animal Science, Hannover Medical School, Germany.
ORCID: 0000-0002-9062-4065

Rupert Palme (R)

Department of Biomedical Sciences, University of Veterinary Medicine, Austria.

Michael Czaplik (M)

Department of Anesthesiology, University Hospital RWTH Aachen, Germany.
ORCID: 0000-0002-7118-7728

René H Tolba (RH)

Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen University, Faculty of Medicine, Germany.
ORCID: 0000-0002-0383-3994

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Severity assessment using three common...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Échelle d'évaluation du comportement › Severity assessment using three common...
questionsmedicales.fr › Procédures de chirurgie opératoire › Laparotomie › Severity assessment using three common...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Severity assessment using three common...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Severity assessment using three common...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Severity assessment using three common...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Severity assessment using three common...