Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds.
Anti-Bacterial Agents
/ chemistry
Escherichia coli
/ drug effects
Hydrophobic and Hydrophilic Interactions
Microbial Sensitivity Tests
Oxyquinoline
/ chemistry
Staphylococcus aureus
/ drug effects
Streptococcus
/ drug effects
Structure-Activity Relationship
Sulfanilamide
/ chemistry
Zinc
/ chemistry
8-Hydroxyquinoline
Antibacterial
Bactericidal
Bioisostere
Ionophore
Mastitis
Sanitizer
Streptococcus uberis
Sulfonamide
Zincophore
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
28
11
2019
revised:
03
02
2020
accepted:
13
03
2020
pubmed:
2
4
2020
medline:
1
5
2021
entrez:
2
4
2020
Statut:
ppublish
Résumé
A series of substituted sulfonamide bioisosteres of 8-hydroxyquinoline were evaluated for their antibacterial activity against the common mastitis causative pathogens Streptococcus uberis, Staphylococcus aureus and Escherichia coli, both in the presence and absence of supplementary zinc. Compounds 9a-e, 10a-c, 11a-e, 12 and 13 were demonstrated to have MICs of 0.0625 µg/mL against S. uberis in the presence of 50 µM ZnSO
Identifiants
pubmed: 32229060
pii: S0960-894X(20)30199-2
doi: 10.1016/j.bmcl.2020.127110
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Sulfanilamide
21240MF57M
Oxyquinoline
5UTX5635HP
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
127110Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.