Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Adamantane
/ analogs & derivatives
Animals
Antiviral Agents
/ pharmacology
Drug Development
Drug Discovery
Drug Resistance, Viral
Humans
Influenza A virus
/ drug effects
Influenza, Human
/ drug therapy
Ion Channels
/ antagonists & inhibitors
Orthomyxoviridae Infections
/ drug therapy
Viral Matrix Proteins
/ antagonists & inhibitors
Virus Replication
/ drug effects
Drug discovery
Drug resistance
Electrophysiology
Influenza
M2
Viroporin
Journal
Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
10
2019
revised:
12
02
2020
accepted:
20
03
2020
pubmed:
2
4
2020
medline:
27
3
2021
entrez:
2
4
2020
Statut:
ppublish
Résumé
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strains that these drugs are no longer recommended. Here we review the current understanding of IAV M2 structure and function, mechanisms of inhibition, the rise of drug resistance mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2.
Identifiants
pubmed: 32229237
pii: S0166-3542(19)30582-0
doi: 10.1016/j.antiviral.2020.104780
pmc: PMC7102647
pii:
doi:
Substances chimiques
Antiviral Agents
0
Ion Channels
0
M2 protein, Influenza A virus
0
Viral Matrix Proteins
0
Adamantane
PJY633525U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104780Subventions
Organisme : NIAID NIH HHS
ID : R21 AI119187
Pays : United States
Organisme : NIAID NIH HHS
ID : R33 AI119187
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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