Prognostic Value of Gleason Score at Positive Surgical Margin in Prostate Cancer: A Systematic Review and Meta-analysis.

Humans Male Margins of Excision Neoplasm Grading Neoplasm Recurrence, Local Prognosis Prostate-Specific Antigen Prostatectomy Prostatic Neoplasms / surgery
Biochemical recurrence Gleason grade PCa PSM Radical prostatectomy

Journal

Clinical genitourinary cancer
ISSN: 1938-0682
Titre abrégé: Clin Genitourin Cancer
Pays: United States
ID NLM: 101260955

Informations de publication

Date de publication:
10 2020
Historique:
received: 11 12 2019
revised: 13 02 2020
accepted: 17 02 2020
pubmed: 2 4 2020
medline: 19 8 2021
entrez: 2 4 2020
Statut: ppublish

Résumé

The individual clinical significance of a positive surgical margin (PSM) after radical prostatectomy has remained controversial. Studies have suggested that the Gleason grade (GG) at the PSM could improve predictive accuracy and decision making. Our objective was to systematically review the reported data to determine the effect of the GG at the PSM on the prognosis after radical prostatectomy. A systematic review was conducted by searching MEDLINE/PubMed for studies reported by June 2019 in accordance with the Preferred Reporting Items for Systematic Review statement. The keywords used included prostate cancer, radical prostatectomy, positive surgical margin, Gleason score, and/or Gleason grade. After a systematic literature review, 10 studies were included, comprising 14,108 patients, of whom 2454 (17.4%) had a PSM and 428 (14%) eventually experienced biochemical recurrence (BCR) within a median follow-up of 18 to 156 months. Data on neoadjuvant or adjuvant therapy were not estimable. In a meta-analysis, GG4 at PSM was significantly associated with BCR compared with GG3 (pooled hazard ratio, 1.87; 95% confidence interval, 1.53-2.28; z = 6.16). The Cochrane Q test (χ

Identifiants

DOI: 10.1016/j.clgc.2020.02.011 PMID: 32229268
pubmed: 32229268
pii: S1558-7673(20)30045-8
doi: 10.1016/j.clgc.2020.02.011
pii:
doi:

Substances chimiques

Prostate-Specific Antigen EC 3.4.21.77

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e517-e522

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Ivan Lysenko (I)

Department of Urology, Medical University of Vienna, Vienna, Austria.

Keiichiro Mori (K)

Department of Urology, Medical University of Vienna, Vienna, Austria; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.

Hadi Mostafaei (H)

Department of Urology, Medical University of Vienna, Vienna, Austria; Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Dmitry V Enikeev (DV)

Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Pierre I Karakiewicz (PI)

Division of Urology, University of Montreal Health Center, Montreal, QC, Canada.

Alberto Briganti (A)

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Fahad Quhal (F)

Department of Urology, Vita Salute San Raffaele University, Milan, Italy.

Florian Janisch (F)

Department of Urology, Medical University of Vienna, Vienna, Austria; King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Shahrokh F Shariat (SF)

Department of Urology, Medical University of Vienna, Vienna, Austria; Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; Department of Urology, Weill Cornell Medical College, New York, NY; Department of Urology, University of Texas Southwestern Medical School, Dallas, TX; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: shahrokh.shariat@meduniwien.ac.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › États, signes et symptômes pathologiques › Résultats morphologiques et microscopiques › Marges d'exérèse › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › Diagnostic › Pronostic › Grading des tumeurs › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène spécifique de la prostate › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Procédures de chirurgie urologique masculine › Prostatectomie › Prognostic Value of Gleason Score at Positive...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Prognostic Value of Gleason Score at Positive...