Chronic Lymphocytic Leukemia.
Journal
Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
pubmed:
2
4
2020
medline:
15
12
2021
entrez:
2
4
2020
Statut:
epublish
Résumé
Patients with chronic lymphocytic leukemia can be divided into three categories: those who are minimally affected by the problem, often never requiring therapy; those that initially follow an indolent course but subsequently progress and require therapy; and those that from the point of diagnosis exhibit an aggressive disease necessitating treatment. Likewise, such patients pass through three phases: development of the disease, diagnosis, and need for therapy. Finally, the leukemic clones of all patients appear to require continuous input from the exterior, most often through membrane receptors, to allow them to survive and grow. This review is presented according to the temporal course that the disease follows, focusing on those external influences from the tissue microenvironment (TME) that support the time lines as well as those internal influences that are inherited or develop as genetic and epigenetic changes occurring over the time line. Regarding the former, special emphasis is placed on the input provided via the B-cell receptor for antigen and the C-X-C-motif chemokine receptor-4 and the therapeutic agents that block these inputs. Regarding the latter, prominence is laid upon inherited susceptibility genes and the genetic and epigenetic abnormalities that lead to the developmental and progression of the disease.
Identifiants
pubmed: 32229611
pii: cshperspect.a035220
doi: 10.1101/cshperspect.a035220
pmc: PMC7849345
pii:
doi:
Substances chimiques
PAX5 Transcription Factor
0
PAX5 protein, human
0
Receptors, Antigen, B-Cell
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA238523
Pays : United States
Informations de copyright
Copyright © 2021 Cold Spring Harbor Laboratory Press; all rights reserved.
Références
Future Oncol. 2016 Jan;12(2):165-74
pubmed: 26515766
Hematol Oncol. 2018 Feb;36(1):370-371
pubmed: 28681549
Eur J Immunol. 1993 Feb;23(2):391-7
pubmed: 8436174
Future Oncol. 2008 Jun;4(3):355-8
pubmed: 18518761
Elife. 2014 Dec 11;3:
pubmed: 25496728
Nature. 2013 Jul 11;499(7457):214-218
pubmed: 23770567
Leukemia. 2010 May;24(5):958-69
pubmed: 20220774
Br J Haematol. 2007 May;137(4):288-96
pubmed: 17456052
Leuk Res. 1991;15(6):487-96
pubmed: 1713635
Cancer Res. 2003 Sep 1;63(17):5480-9
pubmed: 14500384
J Exp Med. 2013 Jan 14;210(1):59-70
pubmed: 23296468
Lancet. 2010 Oct 2;376(9747):1164-74
pubmed: 20888994
N Engl J Med. 2016 Jan 28;374(4):311-22
pubmed: 26639348
J Exp Med. 2001 Dec 3;194(11):1625-38
pubmed: 11733577
Blood. 2014 Jul 10;124(2):188-95
pubmed: 24876563
Nature. 2012 Sep 13;489(7415):309-12
pubmed: 22885698
Eur J Immunol. 2006 May;36(5):1285-95
pubmed: 16619289
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9
pubmed: 16166262
Oncology (Williston Park). 2012 Nov;26(11):1064-6
pubmed: 23330346
J Immunol. 1985 Sep;135(3):1955-60
pubmed: 3926892
Int J Cancer. 2015 Nov 1;137(9):2234-42
pubmed: 25912635
Mol Med. 2006 Nov-Dec;12(11-12):300-8
pubmed: 17380195
Leukemia. 2018 Mar;32(3):645-653
pubmed: 28924241
Am J Pathol. 1928 Jul;4(4):285-292.7
pubmed: 19969796
Br J Haematol. 2017 Feb;176(4):573-582
pubmed: 28032335
Blood. 2015 Mar 5;125(10):1578-88
pubmed: 25564405
Blood. 2011 Jan 13;117(2):563-74
pubmed: 20940416
N Engl J Med. 2008 Aug 7;359(6):575-83
pubmed: 18687638
JCI Insight. 2016 Apr 7;1(4):
pubmed: 27158669
Blood. 2010 Nov 25;116(22):4532-41
pubmed: 20702778
Blood. 2018 Mar 1;131(9):955-962
pubmed: 29255066
Blood. 2016 Jan 14;127(2):208-15
pubmed: 26486789
Cell Rep. 2013 Aug 15;4(3):566-77
pubmed: 23933259
Blood. 2016 Jan 21;127(3):303-9
pubmed: 26492934
N Engl J Med. 2009 Feb 12;360(7):659-67
pubmed: 19213679
Haematologica. 2010 Sep;95(9):1526-33
pubmed: 20421272
N Engl J Med. 2011 Aug 25;365(8):725-33
pubmed: 21830940
Blood. 2002 Jun 1;99(11):4087-93
pubmed: 12010811
Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21194-9
pubmed: 22160699
Blood. 1999 Sep 15;94(6):1840-7
pubmed: 10477712
Blood. 2014 May 22;123(21):3247-54
pubmed: 24652989
Blood. 2016 Mar 3;127(9):1117-27
pubmed: 26813675
J Immunol. 1988 Dec 1;141(11):3994-8
pubmed: 3141510
Blood. 2012 Dec 6;120(24):4802-11
pubmed: 23071276
Blood. 2003 Nov 1;102(9):3333-9
pubmed: 12855567
N Engl J Med. 2011 Dec 29;365(26):2497-506
pubmed: 22150006
Leukemia. 2017 Dec;31(12):2608-2614
pubmed: 28465528
Blood. 1990 Aug 1;76(3):562-9
pubmed: 2378986
J Clin Invest. 2016 Feb;126(2):585-98
pubmed: 26690702
J Clin Oncol. 2011 Jun 1;29(16):2223-9
pubmed: 21483000
Nat Med. 2013 Feb;19(2):202-8
pubmed: 23291630
PLoS One. 2014 Oct 22;9(10):e109332
pubmed: 25337994
Mod Pathol. 2010 Feb;23(2):177-86
pubmed: 19898425
Leukemia. 2013 Jan;27(1):136-41
pubmed: 22781591
Haematologica. 2012 Jan;97(1):153-4
pubmed: 21993686
Blood. 2002 Jul 15;100(2):635-9
pubmed: 12091358
J Clin Oncol. 2017 Sep 10;35(26):3010-3020
pubmed: 28715249
Clin Trials. 2010 Oct;7(5):567-73
pubmed: 20392785
Blood Cancer J. 2018 Dec 21;9(1):1
pubmed: 30602759
Nat Genet. 2014 Jan;46(1):56-60
pubmed: 24292274
Leukemia. 2016 Jan;30(1):182-9
pubmed: 26165233
Nat Rev Clin Oncol. 2014 Jan;11(1):6-8
pubmed: 24281057
Leukemia. 2016 Apr;30(4):833-43
pubmed: 26582643
Blood. 2016 Jul 14;128(2):195-203
pubmed: 27247136
J Exp Med. 2007 Mar 19;204(3):633-43
pubmed: 17353367
Clin Cancer Res. 2001 Nov;7(11):3580-9
pubmed: 11705880
Leukemia. 2016 Jun;30(6):1301-10
pubmed: 26847028
Leukemia. 2013 Aug;27(8):1659-65
pubmed: 23419792
Blood. 2004 Mar 15;103(6):2337-42
pubmed: 14630808
Blood. 1999 Mar 1;93(5):1732-7
pubmed: 10029603
BMC Med. 2013 May 09;11:124
pubmed: 23656622
Br J Haematol. 2016 Jan;172(1):48-55
pubmed: 26559905
Leukemia. 2019 Mar;33(3):653-661
pubmed: 30568170
J Exp Med. 2012 Nov 19;209(12):2183-98
pubmed: 23091163
Clin Cancer Res. 2008 Jan 15;14(2):396-404
pubmed: 18223214
Scientifica (Cairo). 2014;2014:208928
pubmed: 25101192
Blood. 2009 Apr 30;113(18):4188-96
pubmed: 19015397
Leukemia. 2016 Feb;30(2):492-500
pubmed: 26369987
J Biol Chem. 2016 Apr 1;291(14):7558-70
pubmed: 26851280
Blood. 2008 Apr 1;111(7):3838-48
pubmed: 18223168
N Engl J Med. 2000 Dec 28;343(26):1910-6
pubmed: 11136261
Blood. 2011 May 19;117(20):5463-72
pubmed: 21385850
Am J Surg Pathol. 2007 Oct;31(10):1605-14
pubmed: 17895764
Blood. 2010 Dec 23;116(26):5957-60
pubmed: 20855867
Blood. 2016 Jun 23;127(25):3215-24
pubmed: 27069256
Blood. 2007 Jun 1;109(11):4679-85
pubmed: 17299097
Blood. 2012 Jan 12;119(2):521-9
pubmed: 22077063
Blood. 2016 Jun 16;127(24):3015-25
pubmed: 27002119
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80
pubmed: 20615965
European J Clin Med Oncol. 2010 Feb;2(1):119-126
pubmed: 21191471
J Biol Chem. 1999 Jun 25;274(26):18470-6
pubmed: 10373455
Blood. 2011 Feb 10;117(6):1911-6
pubmed: 21131588
Haematologica. 2010 Mar;95(3):464-9
pubmed: 19903673
Nat Genet. 2012 Nov;44(11):1236-42
pubmed: 23064414
J Exp Med. 2011 Jul 4;208(7):1389-401
pubmed: 21670202
Br J Haematol. 2016 Apr;173(2):316-7
pubmed: 26194336
Blood. 2007 Mar 1;109(5):2198-201
pubmed: 17082317
Environ Health Perspect. 2013 Jan;121(1):59-65
pubmed: 23149165
Semin Hematol. 2010 Apr;47(2):107-14
pubmed: 20350657
J Exp Med. 2004 Aug 16;200(4):519-25
pubmed: 15314077
Int J Cancer. 2008 Sep 1;123(5):1190-5
pubmed: 18546292
Leukemia. 2017 Feb;31(2):282-291
pubmed: 27811850
Blood. 2005 Aug 1;106(3):1012-20
pubmed: 15860672
Blood. 2015 Jan 15;125(3):492-8
pubmed: 25377784
Immunol Today. 1994 Jun;15(6):288-94
pubmed: 7520700
Cancer Cell. 2011 Aug 16;20(2):246-59
pubmed: 21840488
Radiat Res. 2008 Dec;170(6):691-7
pubmed: 19138036
Blood. 2011 Nov 3;118(18):4817-28
pubmed: 21849486
Nature. 2001 Jul 19;412(6844):341-6
pubmed: 11460166
Nat Immunol. 2006 Mar;7(3):293-301
pubmed: 16429139
Blood. 2018 Jun 21;131(25):2745-2760
pubmed: 29540348
Blood. 2019 Jun 27;133(26):2765-2775
pubmed: 30862645
Cancer Discov. 2014 Mar;4(3):348-61
pubmed: 24356097
Proc Natl Acad Sci U S A. 1989 Dec;86(24):10024-8
pubmed: 2513569
PLoS One. 2013 Dec 23;8(12):e83830
pubmed: 24376763
Nat Genet. 2008 Oct;40(10):1204-10
pubmed: 18758461
Semin Cancer Biol. 2018 Aug;51:1-11
pubmed: 29427646
Leukemia. 2003 Dec;17(12):2257-317
pubmed: 14671650
Leukemia. 2012 Jun;26(6):1301-12
pubmed: 22289918
Blood. 2015 Jul 9;126(2):203-11
pubmed: 25800048
Leukemia. 2018 Feb;32(2):332-342
pubmed: 28584254
Blood Cancer J. 2015 Jan 30;5:e277
pubmed: 25635530
Leukemia. 2007 Dec;21(12):2442-51
pubmed: 17805327
J Clin Oncol. 2012 Mar 20;30(9):980-8
pubmed: 22331940
MAbs. 2016 May-Jun;8(4):787-98
pubmed: 26963739
Nat Commun. 2017 Jun 09;8:15746
pubmed: 28598442
Blood. 2015 Jun 4;125(23):3580-7
pubmed: 25900981
J Immunol. 2001 Jan 1;166(1):95-102
pubmed: 11123281
Blood. 2009 Mar 26;113(13):3050-8
pubmed: 19074730
Cancer. 1981 Jul 1;48(1):198-206
pubmed: 7237385
Br J Haematol. 1986 Mar;62(3):567-75
pubmed: 3954968
Blood. 2012 May 10;119(19):4467-75
pubmed: 22415752
Haematologica. 2016 Aug;101(8):959-67
pubmed: 27198719
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2879-84
pubmed: 21282663
Blood. 2013 Jan 3;121(1):239-41
pubmed: 23287626
Biochem J. 2017 Oct 23;474(21):3643-3657
pubmed: 29061914
Blood. 2009 Jan 8;113(2):403-11
pubmed: 18948572
Biochem J. 1996 Jan 1;313 ( Pt 1):17-29
pubmed: 8546679
Mod Pathol. 2012 Feb;25(2):237-45
pubmed: 22080061
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1500-7
pubmed: 23550156
Oncotarget. 2017 Jul 24;8(41):71234-71248
pubmed: 29050359
Leukemia. 2012 Jul;26(7):1698-701
pubmed: 22261920
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13242-7
pubmed: 16141332
Blood. 2004 Sep 15;104(6):1850-4
pubmed: 15161669
Acta Haematol. 1989;81(4):181-5
pubmed: 2502891
Blood. 2018 Dec 6;132(23):2446-2455
pubmed: 30287523
Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3562-70
pubmed: 14506142
Radiat Res. 2008 Dec;170(6):721-35
pubmed: 19138033
Blood. 2007 Dec 1;110(12):4012-21
pubmed: 17699742
Scand J Haematol. 1980 Feb;24(2):174-80
pubmed: 6154964
N Engl J Med. 2013 Jul 4;369(1):32-42
pubmed: 23782158
Leukemia. 2015 Mar;29(3):598-605
pubmed: 25151957
Br J Haematol. 2008 Mar;140(5):537-46
pubmed: 18275431
PLoS One. 2011;6(6):e21018
pubmed: 21698301
Leukemia. 2016 Apr;30(4):929-36
pubmed: 26639181
Leuk Lymphoma. 2011 Jun;52(6):1080-4
pubmed: 21417824
Methods Mol Biol. 2019;1956:157-197
pubmed: 30779035
J Immunol. 1989 Jul 15;143(2):699-705
pubmed: 2661689
Blood. 2016 Dec 15;128(24):2770-2773
pubmed: 27697770
Br J Haematol. 2009 Nov;147(3):339-46
pubmed: 19709083
Radiat Res. 2008 Dec;170(6):698-710
pubmed: 19138037
Leukemia. 2016 Feb;30(2):331-6
pubmed: 26310541
Cancer Res. 2008 Dec 15;68(24):10137-44
pubmed: 19074880
Blood. 1975 Aug;46(2):219-34
pubmed: 1139039
J Clin Invest. 2005 Mar;115(3):755-64
pubmed: 15711642
Cancer Res. 2014 Aug 15;74(16):4211-6
pubmed: 25074616
Cell. 2000 Sep 1;102(5):553-63
pubmed: 11007474
Leukemia. 2018 Apr;32(4):1041-1044
pubmed: 29203856
Br J Haematol. 2007 Dec;139(5):791-8
pubmed: 17941950
Blood. 2000 Oct 15;96(8):2655-63
pubmed: 11023495
Lancet Oncol. 2018 Jan;19(1):65-75
pubmed: 29246803
Br J Haematol. 2005 Aug;130(3):325-32
pubmed: 16042682
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3047-52
pubmed: 18287027
N Engl J Med. 2014 Jun 12;370(24):2352-4
pubmed: 24869597
Annu Rev Immunol. 2003;21:841-94
pubmed: 12615894
Blood. 1992 Nov 1;80(9):2287-97
pubmed: 1421400
Blood. 2002 Aug 15;100(4):1410-6
pubmed: 12149225
Leukemia. 2006 Jun;20(6):1089-95
pubmed: 16541139
J Exp Med. 1995 Apr 1;181(4):1507-17
pubmed: 7535340
Clin Cancer Res. 2013 Aug 15;19(16):4309-14
pubmed: 23719265
Nat Immunol. 2011 Jan;12(1):62-9
pubmed: 21113164
Blood. 2001 May 1;97(9):2777-83
pubmed: 11313271
Br J Cancer. 1984 Nov;50(5):587-99
pubmed: 6388614
Blood. 2004 Jan 15;103(2):375-82
pubmed: 14504108
Br J Haematol. 2019 Apr;185(2):363-366
pubmed: 30028000
J Clin Invest. 2004 Apr;113(7):1008-16
pubmed: 15057307
Blood. 2012 Mar 15;119(11):2590-4
pubmed: 22279054
Sci Transl Med. 2016 Sep 7;8(355):355ra116
pubmed: 27605551
Leukemia. 2010 Mar;24(3):512-20
pubmed: 20090778
Histopathology. 1994 May;24(5):445-51
pubmed: 8088716
Leuk Lymphoma. 2002 Mar;43(3):461-6
pubmed: 12002747
Clin Cancer Res. 2016 Apr 1;22(7):1572-82
pubmed: 26660519
Leukemia. 2013 Apr;27(5):1100-6
pubmed: 23295735
Nature. 2015 Oct 22;526(7574):525-30
pubmed: 26466571
Blood. 2016 Jul 28;128(4):553-62
pubmed: 27226435
Leuk Lymphoma. 2019 Jun;60(6):1447-1453
pubmed: 30730240
Blood. 2014 May 22;123(21):3286-95
pubmed: 24659631
Leukemia. 2017 Dec;31(12):2615-2622
pubmed: 28465529
Nat Genet. 2013 Aug;45(8):868-76
pubmed: 23770605
PLoS One. 2019 Feb 20;14(2):e0211228
pubmed: 30785921
Leukemia. 2016 Jul;30(7):1510-9
pubmed: 27055869
Leuk Lymphoma. 2019 Mar;60(3):795-804
pubmed: 30376743
Cytometry B Clin Cytom. 2003 Mar;52(1):1-12
pubmed: 12599176
Eur J Cancer. 2008 May;44(7):946-53
pubmed: 18396036
Am J Surg Pathol. 1998 Jan;22(1):49-56
pubmed: 9422315
Br J Haematol. 2009 Nov;147(4):444-9
pubmed: 19725826
Eur J Immunol. 2011 Aug;41(8):2397-403
pubmed: 21604259
Free Radic Biol Med. 2001 Jun 1;30(11):1286-92
pubmed: 11368926
Exp Oncol. 2006 Mar;28(1):60-3
pubmed: 16614710
Oncotarget. 2015 Dec 8;6(39):42130-49
pubmed: 26517523
Blood. 2003 May 15;101(10):4098-104
pubmed: 12531810
Blood. 2015 Mar 26;125(13):2062-7
pubmed: 25573991
J Immunol. 1997 Jan 1;158(1):235-46
pubmed: 8977195
Blood. 2002 Oct 1;100(7):2289-90
pubmed: 12239136
Blood. 2012 Feb 2;119(5):1182-9
pubmed: 22180443
J Exp Med. 1983 Jan 1;157(1):202-18
pubmed: 6600267
Immunity. 2008 Dec 19;29(6):912-21
pubmed: 19084434
Nature. 2010 Jan 14;463(7278):184-90
pubmed: 20016488
JAMA Oncol. 2015 Apr;1(1):80-7
pubmed: 26182309
Blood. 2007 Jun 15;109(12):5079-86
pubmed: 17351108
J Immunol. 1996 Jan 15;156(2):727-34
pubmed: 8543826
Lancet Oncol. 2015 Feb;16(2):169-76
pubmed: 25555420
Cancer. 2011 May 1;117(9):1891-900
pubmed: 21509766
Blood. 2008 Sep 1;112(5):1923-30
pubmed: 18577710
Am J Hematol. 2017 Apr;92(4):375-380
pubmed: 28120419
Blood. 2008 Dec 15;112(13):5122-9
pubmed: 18812466
Immunol Today. 1993 Feb;14(2):84-7; discussion 87-91
pubmed: 7680563
Leukemia. 2014 Dec;28(12):2395-8
pubmed: 25034147
Cell Res. 2013 Feb;23(2):182-5
pubmed: 23147791
Blut. 1984 Mar;48(3):171-5
pubmed: 6697005
J Immunol. 2002 Dec 1;169(11):6594-603
pubmed: 12444172
Nature. 2011 Jun 05;475(7354):101-5
pubmed: 21642962
J Clin Oncol. 2009 Aug 20;27(24):3959-63
pubmed: 19620484
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11816-21
pubmed: 9751748
Blood. 2015 Oct 15;126(16):1921-4
pubmed: 26276669
Occup Environ Med. 2015 Jun;72(6):435-41
pubmed: 25694496
Cancer Cell. 2010 Jan 19;17(1):28-40
pubmed: 20060366
Blood. 2009 Dec 3;114(24):4928-32
pubmed: 19828698
Cell Rep. 2016 Feb 23;14(7):1748-1760
pubmed: 26876171
Cancer Discov. 2019 Mar;9(3):342-353
pubmed: 30514704
Curr Treat Options Oncol. 2017 Nov 21;18(12):75
pubmed: 29159711
Immunity. 2007 Jan;26(1):93-104
pubmed: 17239630
Clin Cancer Res. 2009 Jul 1;15(13):4415-22
pubmed: 19509140
Blood. 2003 Sep 15;102(6):2146-55
pubmed: 12763926
Ann Oncol. 2016 Jun;27(6):1100-1106
pubmed: 26912560
Am J Hematol. 2016 Jan;91(1):146-50
pubmed: 26574400
Haematologica. 2018 Jun;103(6):e237-e240
pubmed: 29419435
Chem Biol. 2014 Dec 18;21(12):1670-9
pubmed: 25467125
Blood. 2012 Mar 22;119(12):2709-20
pubmed: 22160384
Leukemia. 2017 Jun;31(6):1348-1354
pubmed: 28115735
J Exp Med. 2003 Nov 17;198(10):1539-50
pubmed: 14610042
Chem Immunol. 2000;75:99-120
pubmed: 10851781
Blood. 2004 Nov 1;104(9):2879-85
pubmed: 15217826
J Exp Med. 2013 Oct 21;210(11):2273-88
pubmed: 24127483
J Exp Med. 2011 Jan 17;208(1):67-80
pubmed: 21220451
Leuk Res. 2000 Aug;24(8):665-9
pubmed: 10936420
Am J Hematol. 1998 Nov;59(3):223-9
pubmed: 9798660
Cancer. 1987 Dec 1;60(11):2712-6
pubmed: 3677006
Nat Rev Clin Oncol. 2017 Oct;14(10):588
pubmed: 28762387
Nat Genet. 2011 Dec 11;44(1):47-52
pubmed: 22158541
Best Pract Res Clin Haematol. 2010 Mar;23(1):71-84
pubmed: 20620972
J Clin Oncol. 2010 Oct 10;28(29):4473-9
pubmed: 20697090
N Engl J Med. 2003 May 1;348(18):1764-75
pubmed: 12724482
Blood. 2014 Dec 11;124(25):3829-30
pubmed: 25498454
J Clin Oncol. 2008 May 10;26(14):e5-6
pubmed: 18467710
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9
pubmed: 12434020
Nat Genet. 2016 Mar;48(3):253-64
pubmed: 26780610
Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S167-9
pubmed: 26297272
PLoS One. 2016 Mar 09;11(3):e0149331
pubmed: 26959643
N Engl J Med. 2014 Mar 13;370(11):997-1007
pubmed: 24450857
Blood. 2004 Nov 15;104(10):3318-25
pubmed: 15304391
Methods Mol Biol. 2019;1956:139-155
pubmed: 30779034
Haematologica. 2019 May;104(5):1004-1015
pubmed: 30409799
Blood. 2003 Jun 15;101(12):4952-7
pubmed: 12586612
Blood. 2013 Feb 21;121(8):1403-12
pubmed: 23243274
J Clin Oncol. 2005 Jun 20;23(18):4079-88
pubmed: 15767648
Br J Haematol. 2009 Jun;146(1):64-75
pubmed: 19438485
Leukemia. 2017 Jun;31(6):1340-1347
pubmed: 28074063
Radiat Res. 1994 Feb;137(2 Suppl):S68-97
pubmed: 8127953
Blood. 1992 Jun 1;79(11):2981-9
pubmed: 1375120
N Engl J Med. 2014 Mar 20;370(12):1101-10
pubmed: 24401022
J Hematol Oncol. 2015 May 29;8:60
pubmed: 26022368
Blood. 2016 Dec 22;128(25):2931-2940
pubmed: 27815263
Haematologica. 2008 Oct;93(10):1575-9
pubmed: 18641015
Leukemia. 2016 Mar;30(3):570-9
pubmed: 26522085
Blood Adv. 2017 May 02;1(12):715-727
pubmed: 29296715
Haematologica. 2011 Feb;96(2):277-83
pubmed: 20971821
Expert Rev Hematol. 2019 Mar;12(3):195-205
pubmed: 30793644
J Exp Med. 2001 Dec 3;194(11):1639-47
pubmed: 11733578
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Leukemia. 2014 Jan;28(1):34-43
pubmed: 23979521
Leukemia. 2015 Apr;29(4):895-900
pubmed: 25189416
Nat Commun. 2015 Dec 07;6:8866
pubmed: 26638776
J Autoimmun. 1988 Oct;1(5):469-81
pubmed: 2473761
Leuk Lymphoma. 2007 Jun;48(6):1087-91
pubmed: 17577771
Nat Commun. 2017 Feb 06;8:14175
pubmed: 28165464
Blood. 2018 Jan 18;131(3):365-368
pubmed: 29084773
Leuk Lymphoma. 2015 Jun;56(6):1643-50
pubmed: 25308294
J Clin Oncol. 2011 Nov 1;29(31):4088-95
pubmed: 21969505
Blood. 2002 Feb 1;99(3):1030-7
pubmed: 11807009
BMC Genomics. 2017 Sep 13;18(1):728
pubmed: 28903739
Blood. 2014 Apr 10;123(15):2378-88
pubmed: 24550227
PLoS One. 2015 Dec 02;10(12):e0142466
pubmed: 26630576
Blood. 2014 May 29;123(22):3390-7
pubmed: 24615777
Haematologica. 2018 May;103(5):865-873
pubmed: 29449433
Blood. 2014 Mar 20;123(12):1810-7
pubmed: 24415539
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):720-4
pubmed: 8421711
J Exp Med. 1988 Mar 1;167(3):840-52
pubmed: 3127527
Blood. 2015 Jul 23;126(4):445-53
pubmed: 26065654
Br J Haematol. 2006 Apr;133(1):50-8
pubmed: 16512828
Lancet. 1994 Sep 24;344(8926):862-3
pubmed: 7916406
Leukemia. 2014 Nov;28(11):2188-96
pubmed: 24699307
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13906-11
pubmed: 25201956
Haematologica. 2015 Dec;100(12):1571-8
pubmed: 26430171
Blood. 1989 Jul;74(1):19-25
pubmed: 2473795
Blood. 2009 May 28;113(22):5549-57
pubmed: 19318683
JCI Insight. 2017 Jan 26;2(2):e89904
pubmed: 28138560
Blood. 2015 Apr 16;125(16):2497-506
pubmed: 25700432
Nat Genet. 2010 Feb;42(2):132-6
pubmed: 20062064
Best Pract Res Clin Haematol. 2007 Sep;20(3):399-413
pubmed: 17707829
Mol Med. 2011;17(11-12):1374-82
pubmed: 21968788
Blood. 2011 Jun 9;117(23):6287-96
pubmed: 21422473
Leukemia. 2015 Dec;29(12):2411-4
pubmed: 26256637
J Exp Med. 1989 Jan 1;169(1):255-68
pubmed: 2462608
PLoS One. 2013 Oct 24;8(10):e78339
pubmed: 24205204
Leuk Lymphoma. 2014 Jan;55(1):63-6
pubmed: 23573826
Clin Immunol. 2016 Nov;172:44-51
pubmed: 27586592
Nat Commun. 2016 Mar 09;7:10933
pubmed: 26956414
Cancer Discov. 2019 Feb;9(2):OF3
pubmed: 30541773
PLoS One. 2012;7(12):e52808
pubmed: 23285188
Blood. 2008 Aug 15;112(4):975-80
pubmed: 18411418
J Clin Invest. 1998 Oct 15;102(8):1515-25
pubmed: 9788964
Blood. 2010 Nov 18;116(20):4099-102
pubmed: 20668228
Cell Death Differ. 2018 Jan;25(1):27-36
pubmed: 29099483
Haematologica. 2017 Oct;102(10):1629-1639
pubmed: 28775119
Nature. 2015 Oct 22;526(7574):519-24
pubmed: 26200345
Hematol Oncol. 2013 Mar;31(1):54-5
pubmed: 22461140
Blood. 2012 Jul 26;120(4):843-6
pubmed: 22700719
Br J Haematol. 2008 Oct;143(2):240-7
pubmed: 18710389
Clin Cancer Res. 2015 Oct 15;21(20):4642-51
pubmed: 26089373
Int J Epidemiol. 2019 Oct 1;48(5):1519-1535
pubmed: 30880337
J Clin Oncol. 2014 Mar 20;32(9):897-904
pubmed: 24516016
Blood. 2016 Feb 25;127(8):1007-16
pubmed: 26675346
Blood. 2008 Feb 1;111(3):1524-33
pubmed: 17959859
Cancer Cell. 2014 Dec 8;26(6):813-825
pubmed: 25490447
J Exp Med. 2002 Sep 2;196(5):629-39
pubmed: 12208878
Cell. 2013 Feb 14;152(4):714-26
pubmed: 23415222
Blood. 1996 Mar 15;87(6):2428-34
pubmed: 8630407
Blood. 2003 May 15;101(10):4029-32
pubmed: 12521993
Blood. 2010 May 13;115(19):3907-15
pubmed: 20110421
Blood. 2008 Jan 15;111(2):865-73
pubmed: 17959854
J Clin Invest. 2005 Jun;115(6):1636-43
pubmed: 15902303
Cancer Res. 2009 May 1;69(9):4001-9
pubmed: 19383907
Leuk Res. 2011 Oct;35(10):1390-4
pubmed: 21813176
Blood. 2003 Jun 15;101(12):4903-8
pubmed: 12586616
Cancer Discov. 2014 Sep;4(9):1088-101
pubmed: 24920063
N Engl J Med. 2012 Jun 28;366(26):2530
pubmed: 22738114
N Engl J Med. 2014 Jun 12;370(24):2286-94
pubmed: 24869598
Blood. 2003 Feb 1;101(3):1045-52
pubmed: 12393541
Mol Med. 2013 Aug 28;19:245-52
pubmed: 23922242
Br J Haematol. 2012 Aug;158(3):426-9
pubmed: 22571487
Blood. 1999 Sep 15;94(6):1848-54
pubmed: 10477713
J Clin Invest. 2008 Jul;118(7):2427-37
pubmed: 18551193
Leukemia. 2013 Jan;27(1):142-9
pubmed: 23041722
N Engl J Med. 2015 Jan 22;372(4):311-9
pubmed: 25482239
Leuk Lymphoma. 2018 Jun;59(6):1348-1355
pubmed: 28905668
Blood Adv. 2018 Feb 13;2(3):210-223
pubmed: 29386194
Blood. 2007 Jan 1;109(1):259-70
pubmed: 16985177
Mol Cell. 2009 Nov 25;36(4):631-41
pubmed: 19941823
Blood. 2012 Mar 8;119(10):2293-301
pubmed: 22234695
Int J Hematol Oncol. 2019 Jan 08;7(4):IJH09
pubmed: 30651968