Recombinant Measles AIK-C Vaccine Strain Expressing Influenza HA Protein.
HI antibodies
hemagglutinin
influenza virus
measles AIK-C
recombinant virus
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
27 Mar 2020
27 Mar 2020
Historique:
received:
17
02
2020
revised:
24
03
2020
accepted:
25
03
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
epublish
Résumé
Recombinant measles AIK-C vaccine expressing the hemagglutinin (HA) protein of influenza A/Sapporo/107/2013(H1N1pdm) (MVAIK/PdmHA) was constructed. Measles particle agglutination (PA) and influenza hemagglutinin inhibition (HI) antibodies were induced in cotton rats immunized with MVAIK/PdmHA. Cotton rats immunized with two doses of the HA split vaccine were used as positive controls, and higher HI antibodies were detected 3 weeks after the first dose. Following the challenge of A/California/07/2009(H1N1pdm), higher viral loads (10
Identifiants
pubmed: 32230902
pii: vaccines8020149
doi: 10.3390/vaccines8020149
pmc: PMC7349030
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
T.N. received research funding from Daiichi-Sankyo Pharmaceutical and Kitasato-Daiichi Sankyo Vaccine. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.
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