Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan.
Journal
TheScientificWorldJournal
ISSN: 1537-744X
Titre abrégé: ScientificWorldJournal
Pays: United States
ID NLM: 101131163
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
11
2019
accepted:
20
02
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
21
10
2020
Statut:
epublish
Résumé
In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients. We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathology at No 1 Hospital of Liangshan. The ethnic groups Han and Yi were almost equally distributed in this cohort. Over a five-year period, 1407 GC were diagnosed. In 171 of these cases (12%), the patients were ≤40 years old (early-onset GC, EOGC). Out of this cohort, 9 patients were aged ≤25 years. 54% of these patients were male and showed marked predominance (92%) of the Yi-minority. Using the classification of Lauren, 103 GC (60%) were of diffuse type, 27 (16%) of intestinal type, and 41 (24%) of mixed type. In the remaining 1,236 cases of patients ≥41 years (88%), 1,014 patients (82%) belonged to the Yi-minority. This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition.
Sections du résumé
BACKGROUND
BACKGROUND
In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients.
METHODS
METHODS
We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathology at No 1 Hospital of Liangshan. The ethnic groups Han and Yi were almost equally distributed in this cohort. Over a five-year period, 1407 GC were diagnosed.
RESULTS
RESULTS
In 171 of these cases (12%), the patients were ≤40 years old (early-onset GC, EOGC). Out of this cohort, 9 patients were aged ≤25 years. 54% of these patients were male and showed marked predominance (92%) of the Yi-minority. Using the classification of Lauren, 103 GC (60%) were of diffuse type, 27 (16%) of intestinal type, and 41 (24%) of mixed type. In the remaining 1,236 cases of patients ≥41 years (88%), 1,014 patients (82%) belonged to the Yi-minority.
CONCLUSION
CONCLUSIONS
This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition.
Identifiants
pubmed: 32231466
doi: 10.1155/2020/6845413
pmc: PMC7085875
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6845413Informations de copyright
Copyright © 2020 Shen Li et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
J Transl Med. 2013 Mar 06;11:58
pubmed: 23497313
Anticancer Res. 2017 Aug;37(8):4671-4679
pubmed: 28739770
Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1883-1886
pubmed: 30049355
J Mol Diagn. 2005 Oct;7(4):465-77
pubmed: 16237216
Scand J Gastroenterol. 2001 Feb;36(2):208-13
pubmed: 11252415
Pathol Oncol Res. 2016 Jan;22(1):197-202
pubmed: 26502923
Oncol Lett. 2010 May;1(3):407-412
pubmed: 22966316
J Epidemiol. 2003 May;13(3):162-8
pubmed: 12749604
J Gastrointest Oncol. 2012 Sep;3(3):251-61
pubmed: 22943016
Gastric Cancer. 2010 Mar;13(1):1-10
pubmed: 20373070
J Natl Cancer Inst. 1991 May 1;83(9):640-3
pubmed: 2023282
J Gastroenterol. 2019 May;54(5):419-426
pubmed: 30374622
J Med Genet. 2015 Jun;52(6):361-74
pubmed: 25979631
Acta Pathol Microbiol Scand. 1965;64:31-49
pubmed: 14320675
Int J Cancer. 2006 Jul 1;119(1):196-201
pubmed: 16450397
J Gastroenterol Hepatol. 2011 Nov;26(11):1626-9
pubmed: 21557767
Int J Cancer. 2002 Mar 20;98(3):446-9
pubmed: 11920598
Nature. 1998 Mar 26;392(6674):402-5
pubmed: 9537325
Pathologe. 2010 Oct;31(6):423-9
pubmed: 20824432
Cancer Manag Res. 2018 Feb 07;10:239-248
pubmed: 29445300