ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.
Animals
Cell Cycle Proteins
/ genetics
Disease Resistance
Gene Expression Profiling
HeLa Cells
Humans
Immune Tolerance
Immunity
Immunity, Innate
Influenza A virus
/ physiology
Influenza, Human
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins
/ genetics
Nuclear Proteins
/ genetics
Orthomyxoviridae Infections
/ immunology
ANP32A
ANP32B
antiviral immunity
influenza A virus
pathogenesis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
11
2019
accepted:
27
02
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
20
3
2021
Statut:
epublish
Résumé
Deciphering complex virus-host interactions is crucial for pandemic preparedness. In this study, we assessed the impact of recently postulated cellular factors ANP32A and ANP32B of influenza A virus (IAV) species specificity on viral pathogenesis in a genetically modified mouse model. Infection of ANP32A
Identifiants
pubmed: 32231671
doi: 10.3389/fimmu.2020.00450
pmc: PMC7083139
doi:
Substances chimiques
Anp32b protein, mouse
0
Cell Cycle Proteins
0
Nerve Tissue Proteins
0
Nuclear Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
450Informations de copyright
Copyright © 2020 Beck, Zickler, Pinho dos Reis, Günther, Grundhoff, Reilly, Mak, Stanelle-Bertram and Gabriel.
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