Impact of diabetes on gastrointestinal and urinary toxicity after radiotherapy for gynecologic malignancy.
Diabetes
gynecologic tumor
pelvic radiotherapy
radiation toxicity
Journal
Turkish journal of obstetrics and gynecology
ISSN: 2149-9322
Titre abrégé: Turk J Obstet Gynecol
Pays: Turkey
ID NLM: 101656661
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
14
05
2019
accepted:
12
10
2019
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
ppublish
Résumé
Although diabetes is a common co-morbidity in patients with gynecologic cancer, information about its impact on radiation toxicity in patients with gynecologic cancer treated with external pelvic irradiation is scarce. We aimed to investigate the relation of diabetes with acute toxicity in patients with gynecologic tumors who underwent pelvic +/- paraaortic radiotherapy. One hundred twenty-nine patients with endometrium or cervix carcinoma were enrolled in the study. Demographic features, presence of diabetes, incidence and severity of upper gastrointestinal (UGIS), lower gastrointestinal (LGIS), and urinary symptoms were recorded from files. Correlation and logistic regression analysis was used to determine the impact of diabetes, age, chemotherapy, paraaortic irradiation on toxicities, and a prediction model was developed. The median age of 77 patients with endometrium cancer and 52 cervix cancer was 61 (range, 25-92) years, and 28 (21.7%) of them had diabetes. The median pelvic and tumor/tumor bed dose was 5040+247.65 cGy and 5040+222.91 cGy, respectively. Age and Gr 0 UGIS toxicity were significantly related (p=0.047). LGIS Gr 0 toxicity was found to be significantly higher in patients with diabetes (p=0.045). Gr 0 and 2 UGIS toxicities were both found to be significantly correlated with paraaortic irradiation (both p<0.001). Diabetes is also an important determinant on UGIS toxicity in patients who underwent paraaortic irradiation. The correlation we found between toxicity and diabetes, concurrent chemotherapy or paraaortic radiation necessitates special care and risk stratification for patients with diabetes. Further prospective studies with long follow-up and larger patient groups are warranted.
Identifiants
pubmed: 32231858
doi: 10.4274/tjod.galenos.2019.56957
pii: 36119
pmc: PMC7090259
doi:
Types de publication
Journal Article
Langues
eng
Pagination
260-265Informations de copyright
©Copyright 2019 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House.
Déclaration de conflit d'intérêts
Conflict of Interest: No conflict of interest was declared by the authors.
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