Monepantel (Veterinary Medicinal Products).
Journal
Food safety (Tokyo, Japan)
ISSN: 2187-8404
Titre abrégé: Food Saf (Tokyo)
Pays: Japan
ID NLM: 101685527
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
epublish
Résumé
FSCJ conducted a risk assessment of monepantel (CAS No.887148-69-8), a parasiticide based on results from various studies. Data on pharmacokinetics (cattle) and residues (cattle) were newly submitted. Negative results were obtained in all genotoxicity and carcinogenicity studies. The no-observed-adverse-effect level (NOAEL) obtained in all studies was 100 ppm (equivalent to 3 mg/kg bw per day for both sexes). In the 52-week chronic toxicity study in dogs, FSCJ specified an ADI for monepantel at 0.03 mg/kg bw per day based on NOAEL of 3 mg/kg bw per day, by applying a safety factor of 100.
Identifiants
pubmed: 32231956
doi: 10.14252/foodsafetyfscj.D-20-00001
pii: D-20-00001
pmc: PMC7101469
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4-5Informations de copyright
©2020 Food Safety Commission, Cabinet Office, Government of Japan.