Discovery of Pancreatic Ductal Adenocarcinoma-Related Aberrant Glycosylations: A Multilateral Approach of Lectin Microarray-Based Tissue Glycomic Profiling With Public Transcriptomic Datasets.
ABO blood group antigen
Genotype-Tissue Expression (GTEx)
The Cancer Genome Atlas (TCGA)
basigin/CD147
glycosylation
glycosyltransferase
lectin microarray
multi-omics
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
11
2019
accepted:
26
02
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
epublish
Résumé
Aberrant protein glycosylation is one of the most notable features in cancerous tissues, and thereby glycoproteins with disease-relevant glycosylation alterations are fascinating targets for the development of biomarkers and therapeutic agents. For this purpose, a reliable strategy is needed for the analysis of glycosylation alterations occurring on specific glycoproteins during the progression of cancer. Here, we propose a bilateral approach combining lectin microarray-based tissue glycomic profiling and database-derived transcriptomic datasets. First, lectin microarray was used to perform differential glycomic profiling of crude extracts derived from non-tumor and tumor regions of frozen tissue sections from pancreatic ductal adenocarcinoma (PDAC). This analysis revealed two notable tissue glycome alterations in PDAC samples: increases in sialylated glycans and bisecting
Identifiants
pubmed: 32232009
doi: 10.3389/fonc.2020.00338
pmc: PMC7082313
doi:
Types de publication
Journal Article
Langues
eng
Pagination
338Informations de copyright
Copyright © 2020 Wagatsuma, Nagai-Okatani, Matsuda, Masugi, Imaoka, Yamazaki, Sakamoto and Kuno.
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