Neuromodulation as a new avenue for resuscitation in hemorrhagic shock.
Autonomic nervous system
Electroacupuncture
Hemorrhagic shock
Inflammation
Neuromodulation
Phrenic nerve stimulation
Resuscitation
Trigeminal nerve stimulation
Vagus nerve stimulation
Journal
Bioelectronic medicine
ISSN: 2332-8886
Titre abrégé: Bioelectron Med
Pays: England
ID NLM: 101660849
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
08
2019
accepted:
23
09
2019
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
epublish
Résumé
Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33-56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid therapy and blood transfusions are the cornerstone of treating HS. However, these options may not be available soon after the injury, resulting in death or a poorer quality of survival. Therefore, new strategies are needed to manage HS patients before they can receive definitive care. Recently, various forms of neuromodulation have been investigated as possible supplementary treatments for HS in the prehospital phase of care. Here, we provide an overview of neuromodulation methods that show promise to treat HS, such as vagus nerve stimulation, electroacupuncture, trigeminal nerve stimulation, and phrenic nerve stimulation and outline their possible mechanisms in the treatment of HS. Although all of these approaches are only validated in the preclinical models of HS and are yet to be translated to clinical settings, they clearly represent a paradigm shift in the way that this deadly condition is managed in the future.
Identifiants
pubmed: 32232106
doi: 10.1186/s42234-019-0033-z
pii: 33
pmc: PMC7098257
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
17Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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