Imaging markers associated with the development of post-stroke depression and apathy: Results of the Cognition and Affect after Stroke - a Prospective Evaluation of Risks study.
Depression
apathy
imaging
stroke
Journal
European stroke journal
ISSN: 2396-9881
Titre abrégé: Eur Stroke J
Pays: England
ID NLM: 101688446
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
15
07
2019
accepted:
25
09
2019
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
ppublish
Résumé
It has been suggested that the development of post-stroke apathy (PSA) and depression (PSD) may be more strongly associated with generalised brain pathology, rather than the stroke lesion itself. The present study aimed to investigate associations between imaging markers of lesion-related and generalised brain pathology and the development of PSA and PSD during a one-year follow-up. In a prospective cohort study, 188 stroke patients received 3-Tesla MRI at baseline (three months post-stroke) for evaluation of lesion-related, vascular, and degenerative brain pathology. Presence of lacunes, microbleeds, white matter hyperintensities, and enlarged perivascular spaces was summed to provide a measure of total cerebral small vessel disease (cSVD) burden (range 0-4). The Mini International Neuropsychiatric Interview and Apathy Evaluation Scale were administered at baseline and repeated at 6- and 12-month follow-up to define presence of PSD and PSA, respectively. Population-averaged logistic regression models showed that global brain atrophy and severe cSVD burden (score 3-4) were significantly associated with the odds of having PSA (OR The results suggest that generalised degenerative and vascular brain pathology, rather than lesion-related pathology, is an important predictor for the development of PSA, and less strongly for PSD.
Identifiants
pubmed: 32232173
doi: 10.1177/2396987319883445
pii: 10.1177_2396987319883445
pmc: PMC7092734
doi:
Types de publication
Journal Article
Langues
eng
Pagination
78-84Informations de copyright
© European Stroke Organisation 2019.
Références
Cerebrovasc Dis. 2009;28(3):227-42
pubmed: 19571536
Stroke. 2013 Mar;44(3):851-60
pubmed: 23362076
J Neurol Neurosurg Psychiatry. 2005 Aug;76(8):1070-4
pubmed: 16024880
Eur Arch Psychiatry Clin Neurosci. 2007 Apr;257(3):149-52
pubmed: 17131217
Psychol Med. 2012 Feb;42(2):359-70
pubmed: 21835088
Neurology. 2014 Sep 30;83(14):1228-34
pubmed: 25165388
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573
J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):967-72
pubmed: 1431963
Neurology. 2014 May 6;82(18):1628-35
pubmed: 24739783
Int J Stroke. 2014 Dec;9(8):1017-25
pubmed: 25117911
Stroke. 1993 Jul;24(7):976-82
pubmed: 8322398
Cerebrovasc Dis. 2013;35(1):23-39
pubmed: 23428994
BMC Neurol. 2016 May 12;16:65
pubmed: 27176617
J Neurol. 2015 Jan;262(1):81-90
pubmed: 25308633
Neuropsychiatr Dis Treat. 2015 Feb 03;11:233-42
pubmed: 25678790
AJR Am J Roentgenol. 1987 Aug;149(2):351-6
pubmed: 3496763
J Geriatr Psychiatry Neurol. 2011 Mar;24(1):44-9
pubmed: 21196531
Int J Geriatr Psychiatry. 2015 Jun;30(6):566-72
pubmed: 25092799
Eur J Neurol. 2012 Feb;19(2):291-7
pubmed: 21895880
Eur J Neurol. 2017 Feb;24(2):374-380
pubmed: 27933697
Neuroimage. 2010 Jan 15;49(2):1316-25
pubmed: 19815080
Psychiatry Res. 1991 Aug;38(2):143-62
pubmed: 1754629
Epidemiology. 2010 Jul;21(4):467-74
pubmed: 20220526
Int J Geriatr Psychiatry. 2016 Jan;31(1):58-65
pubmed: 25821003
Eur J Neurol. 2015 Feb;22(2):341-7
pubmed: 25319873
Int J Geriatr Psychiatry. 2008 Oct;23(10):1040-50
pubmed: 18412291
Stroke Res Treat. 2013;2013:424769
pubmed: 23533960
J Psychiatry Neurosci. 2015 Jul;40(4):259-68
pubmed: 25871495
Neuropsychol Rev. 2017 Sep;27(3):202-219
pubmed: 28831649
Brain. 2015 Dec;138(Pt 12):3803-15
pubmed: 26490330
Int Psychogeriatr. 2011 Mar;23(2):264-73
pubmed: 20716386
World J Biol Psychiatry. 2011 Oct;12(7):539-48
pubmed: 21486107
J Geriatr Psychiatry Neurol. 2016 Jul;29(4):171-6
pubmed: 27056065
Brain. 1984 Mar;107 ( Pt 1):81-93
pubmed: 6697163
Neuroimage. 2009 May 1;45(4):1151-61
pubmed: 19344687
Stroke. 1993 Nov;24(11):1625-30
pubmed: 8236333
PLoS One. 2015 Jan 02;10(1):e116168
pubmed: 25555189