The Role of Podocytes and Podocyte-Associated Biomarkers in Diagnosis and Treatment of Diabetic Kidney Disease.
biological markers
biomarkers
diabetes
diabetic kidney disease
podocytes
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Apr 2020
01 Apr 2020
Historique:
received:
29
01
2020
accepted:
27
02
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
epublish
Résumé
Diabetic kidney disease (DKD) is an important public health problem. Podocyte injury is a central event in the mechanism of DKD development. Podocytes are terminally differentiated, highly specialized glomerular visceral epithelial cells critical for the maintenance of the glomerular filtration barrier. Although potential mechanisms by which diabetic milieu contributes to irreversible loss of podocytes have been described, identification of markers that prognosticate either the development of DKD or the progression to end-stage kidney disease (ESKD) have only recently made it to the forefront. Currently, the most common marker of early DKD is microalbuminuria; however, this marker has significant limitations: not all diabetic patients with microalbuminuria will progress to ESKD and as many as 30% of patients with DKD have normal urine albumin levels. Several novel biomarkers indicating glomerular or tubular damage precede microalbuminuria, suggesting that the latter develops when significant kidney injury has already occurred. Because podocyte injury plays a key role in DKD pathogenesis, identification of markers of early podocyte injury or loss may play an important role in the early diagnosis of DKD. Such biomarkers in the urine include podocyte-released microparticles as well as expression of podocyte-specific markers. Here, we review the mechanisms by which podocyte injury contributes to DKD as well as key markers that have been recently implicated in the development and/or progression of DKD and might serve to identify individuals that require earlier preventative care and treatment in order to slow the progression to ESKD.
Identifiants
pubmed: 32232184
doi: 10.1210/jendso/bvaa029
pii: bvaa029
pmc: PMC7093089
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
bvaa029Informations de copyright
© Endocrine Society 2020.
Références
J Diabetes Res. 2017;2017:2379432
pubmed: 29201920
J Clin Invest. 2011 Jun;121(6):2181-96
pubmed: 21606597
Kidney Int. 2015 Jan;87(1):74-84
pubmed: 25075770
Biomark Res. 2013 Feb 04;1(1):9
pubmed: 24252392
BMC Nephrol. 2013 Oct 08;14:214
pubmed: 24103534
Kidney Int. 2008 Mar;73(5):556-66
pubmed: 18033240
Diabetes Metab Res Rev. 2010 Mar;26(3):150-71
pubmed: 20222150
Autophagy. 2015;11(7):1130-45
pubmed: 26039325
J Am Soc Nephrol. 2005 Oct;16(10):2953-66
pubmed: 16120818
J Am Soc Nephrol. 2015 Oct;26(10):2361-77
pubmed: 25644109
Nat Rev Mol Cell Biol. 2003 Jun;4(6):446-56
pubmed: 12778124
Diabetes. 2009 May;58(5):1201-11
pubmed: 19208908
Diabetes. 2015 Dec;64(12):4099-111
pubmed: 26293507
JAMA. 2003 Jun 25;289(24):3273-7
pubmed: 12824208
FASEB J. 2004 Jan;18(1):176-8
pubmed: 12709399
J Clin Invest. 2001 Sep;108(6):807-16
pubmed: 11560950
Kidney Int. 2012 Nov;82(9):1010-7
pubmed: 22718189
Diabetes. 2003 Apr;52(4):1023-30
pubmed: 12663475
Rev Diabet Stud. 2015 Spring-Summer;12(1-2):110-8
pubmed: 26676664
Mol Cell Biol. 2013 Dec;33(23):4755-64
pubmed: 24061480
Nephrol Dial Transplant. 2011 Aug;26(8):2508-14
pubmed: 21196468
J Clin Invest. 2011 Jun;121(6):2197-209
pubmed: 21606591
J Am Soc Nephrol. 2005 Oct;16(10):2941-52
pubmed: 16107576
Pediatr Nephrol. 2012 Jun;27(6):891-900
pubmed: 21603909
J Korean Med Sci. 2009 Jan;24 Suppl:S75-81
pubmed: 19194567
Am J Kidney Dis. 2017 Mar;69(3 Suppl 1):A7-A8
pubmed: 28236831
J Am Soc Nephrol. 2007 Sep;18(9):2525-33
pubmed: 17675666
Semin Nephrol. 2007 Mar;27(2):130-43
pubmed: 17418682
Cell. 2006 Apr 21;125(2):221-4
pubmed: 16630808
J Biol Chem. 2007 Jan 5;282(1):467-77
pubmed: 17082197
Exp Biol Med (Maywood). 2016 Oct;241(16):1865-76
pubmed: 27216597
N Engl J Med. 2001 Sep 20;345(12):851-60
pubmed: 11565517
J Am Soc Nephrol. 2002 Dec;13(12):3005-15
pubmed: 12444221
Clin Sci (Lond). 2013 Apr;124(7):423-41
pubmed: 23249271
Folia Biol (Praha). 2008;54(5):162-7
pubmed: 19178816
Biomark Res. 2014 Nov 23;2:21
pubmed: 25789166
Diabetologia. 2011 May;54(5):1227-41
pubmed: 21318407
J Am Soc Nephrol. 2002 Jun;13(6):1534-47
pubmed: 12039983
Am J Pathol. 2007 Aug;171(2):415-27
pubmed: 17569780
Nephrol Dial Transplant. 2001 Jul;16(7):1382-6
pubmed: 11427629
Kidney Int. 2013 Nov;84(5):920-30
pubmed: 23677246
Kidney Int. 2003 Jan;63(1):225-32
pubmed: 12472787
Physiol Rev. 2008 Apr;88(2):451-87
pubmed: 18391170
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8301-5
pubmed: 12048257
Cell Metab. 2010 Oct 6;12(4):329-340
pubmed: 20889126
J Clin Invest. 2010 Apr;120(4):1084-96
pubmed: 20200449
Biochem Biophys Res Commun. 2003 Jun 13;305(4):1002-7
pubmed: 12767930
Kidney Int Suppl. 2000 Sep;77:S93-8
pubmed: 10997697
Kidney Int. 2002 Sep;62(3):901-13
pubmed: 12164872
Nephrology (Carlton). 2005 Oct;10 Suppl:S14-6
pubmed: 16174280
Am J Physiol Renal Physiol. 2008 Apr;294(4):F697-701
pubmed: 18272603
Kidney Int. 2000 Oct;58(4):1492-9
pubmed: 11012884
Diabetes. 2006 Jan;55(1):225-33
pubmed: 16380497
J Diabetes Complications. 2003 Jan-Feb;17(1):11-5
pubmed: 12505750
J Clin Invest. 2008 May;118(5):1632-44
pubmed: 18414683
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5815-20
pubmed: 25902541
J Am Soc Nephrol. 2019 Apr;30(4):533-545
pubmed: 30846559
N Engl J Med. 1993 Nov 11;329(20):1456-62
pubmed: 8413456
Diabetologia. 2012 Nov;55(11):2913-9
pubmed: 22854890
J Clin Invest. 2006 May;116(5):1346-59
pubmed: 16543952
Life Sci. 2000 Sep 29;67(19):2345-53
pubmed: 11065181
Diabetes Metab Res Rev. 2015 Jan;31(1):50-60
pubmed: 24846128
Curr Diab Rep. 2016 May;16(5):45
pubmed: 27053072
Nephrol Dial Transplant. 2015 Apr;30(4):599-606
pubmed: 25648911
PLoS One. 2012;7(4):e33942
pubmed: 22496773
Nat Rev Immunol. 2010 Mar;10(3):210-5
pubmed: 20168318
Diabetes. 2018 Nov;67(11):2420-2433
pubmed: 30115650
Nature. 2006 Apr 6;440(7085):818-23
pubmed: 16525419
Curr Diab Rep. 2013 Aug;13(4):592-9
pubmed: 23712652
Diabetes. 2008 Jun;57(6):1683-92
pubmed: 18356410
MMWR Morb Mortal Wkly Rep. 2010 Oct 29;59(42):1361-6
pubmed: 21030940
Physiol Rev. 2003 Jan;83(1):253-307
pubmed: 12506131
N Engl J Med. 2002 Apr 11;346(15):1145-51
pubmed: 11948275
J Biol Chem. 2003 Apr 11;278(15):12605-8
pubmed: 12538598
Diabetes. 2003 Apr;52(4):1031-5
pubmed: 12663476
J Biol Chem. 2011 Jul 22;286(29):26003-15
pubmed: 21613219
Diabetes. 2002 May;51(5):1580-7
pubmed: 11978659
Nat Med. 2019 May;25(5):805-813
pubmed: 31011203
J Am Soc Nephrol. 2012 Mar;23(3):507-15
pubmed: 22266663
Clin Lab. 2012;58(7-8):659-71
pubmed: 22997966
PLoS One. 2011;6(5):e20431
pubmed: 21655212
Diabetes. 2010 Aug;59(8):1915-25
pubmed: 20522599
Diabetes. 2007 Apr;56(4):1127-35
pubmed: 17395751
Curr Opin Nephrol Hypertens. 2005 May;14(3):205-10
pubmed: 15821411
Nephrol Dial Transplant. 2000 Sep;15(9):1379-83
pubmed: 10978394
Nat Med. 2008 Mar;14(3):290-8
pubmed: 18311147
Am J Pathol. 2001 Sep;159(3):1069-77
pubmed: 11549599
PLoS One. 2012;7(5):e36041
pubmed: 22615747