Inertial-Force-Assisted, High-Throughput, Droplet-Free, Single-Cell Sampling Coupled with ICP-MS for Real-Time Cell Analysis.

Cadmium / chemistry Copper / chemistry High-Throughput Screening Assays Humans Mass Spectrometry Particle Size Single-Cell Analysis Surface Properties Time Factors Tumor Cells, Cultured

Journal

Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536

Informations de publication

Date de publication:
05 05 2020
Historique:
pubmed: 3 4 2020
medline: 11 2 2021
entrez: 3 4 2020
Statut: ppublish

Résumé

Single-cell analysis facilitates perception into the most essential processes in life's mysteries. While it is highly challenging to quantify them at the single-cell level, where precise single-cell sampling is the prerequisite. Herein, a real-time single-cell quantitative platform was established for high-throughput droplet-free single-cell sampling into time-resolved (TRA) ICP-MS and real-time quantification of intracellular target elements. The concentrated cells (2 × 10

Identifiants

DOI: 10.1021/acs.analchem.0c00376 PMID: 32233376
pubmed: 32233376
doi: 10.1021/acs.analchem.0c00376
doi:

Substances chimiques

Cadmium 00BH33GNGH
Copper 789U1901C5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6604-6612

Auteurs

Xuan Zhang (X)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.

Xing Wei (X)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.

Xue Men (X)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.

Ze Jiang (Z)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.

Wen-Qi Ye (WQ)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.

Ming-Li Chen (ML)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.
ORCID: 0000-0001-8536-8864

Ting Yang (T)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.
ORCID: 0000-0001-5517-5658

Zhang-Run Xu (ZR)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.
ORCID: 0000-0003-3834-1145

Jian-Hua Wang (JH)

Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang, Liaoning 110819, People's Republic of China.
ORCID: 0000-0003-2175-3610

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cadmium › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Phénomènes chimiques › Propriétés de surface › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Inertial-Force-Assisted, High-Throughput,...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Inertial-Force-Assisted, High-Throughput,...