Early epigenetic changes of Alzheimer's disease in the human hippocampus.
Early Alzheimer ’s disease
DNA methylation
ELOVL2
GIT1
biomarkers
epigenetics
fatty acid
hippocampus
histone
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
3
4
2020
medline:
16
6
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
The discovery of new biomarkers would be very valuable to improve the detection of early Alzheimer's disease (AD). DNA methylation marks may serve as epigenetic biomarkers of early AD. Here we identified epigenetic marks that are present in the human hippocampus from the earliest stages of AD. A previous methylome dataset of the human AD hippocampus was used to select a set of eight differentially methylated positions (DMPs) since early AD stages. Next, bisulphite pyrosequencing was performed in an expanded homogeneous cohort of 18 pure controls and 35 hippocampal samples with neuropathological changes of pure AD. Correlation between DNA methylation levels in DMPs and phospho-tau protein burden assessed by immunohistochemistry in the hippocampus was also determined. We found four DMPs showing higher levels of DNA methylation at early AD stages compared to controls, involving AD: Alzheimer's disease; DMPs: Differentially methylated positions; CSF: Cerebrospinal fluid; βA42: β-amyloid 42; PET: positron emission tomography; 5mC: 5-methyl cytosine; CpG: cytosine-guanine dinucleotides;
Identifiants
pubmed: 32233750
doi: 10.1080/15592294.2020.1748917
pmc: PMC7518674
doi:
Substances chimiques
ELOVL2 protein, human
0
Histones
0
MAPT protein, human
0
tau Proteins
0
Fatty Acid Elongases
EC 2.3.1.-
Aspartate Aminotransferase, Cytoplasmic
EC 2.6.1.-
GOT1 protein, human
EC 2.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1083-1092Références
Neurology. 1991 Apr;41(4):479-86
pubmed: 2011243
Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):202-8
pubmed: 19023093
Genes Dev. 2016 Jun 15;30(12):1383-8
pubmed: 27340174
Cancer Discov. 2019 Sep;9(9):1248-1267
pubmed: 31201181
Lipids. 2002 Aug;37(8):733-40
pubmed: 12371743
Science. 2015 May 8;348(6235):660-5
pubmed: 25954002
J Neurosci. 2014 Jul 9;34(28):9213-21
pubmed: 25009255
Clin Epigenetics. 2019 Jun 19;11(1):91
pubmed: 31217032
Aging Cell. 2012 Dec;11(6):1132-4
pubmed: 23061750
Nat Neurosci. 2014 Sep;17(9):1164-70
pubmed: 25129077
Epigenomics. 2015;7(6):1003-15
pubmed: 26479312
J Alzheimers Dis. 2012;29(3):571-88
pubmed: 22451312
J Clin Psychiatry. 2003;64 Suppl 9:7-10
pubmed: 12934968
Nat Cell Biol. 2009 Nov;11(11):1325-31
pubmed: 19855388
Neural Regen Res. 2016 Mar;11(3):427-34
pubmed: 27127481
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Oxid Med Cell Longev. 2012;2012:623257
pubmed: 22919440
Rev Esp Med Nucl Imagen Mol. 2015 Sep-Oct;34(5):303-13
pubmed: 26099942
J Cell Sci. 2002 Apr 1;115(Pt 7):1497-510
pubmed: 11896197
Sci Rep. 2016 Oct 26;6:35807
pubmed: 27782156
Am J Hum Genet. 2011 Dec 9;89(6):745-50
pubmed: 22100072
Am J Pathol. 2006 Mar;168(3):1004-21
pubmed: 16507914
Oncotarget. 2018 Jun 19;9(47):28532-28546
pubmed: 29983878
FEBS Lett. 2001 Nov 30;509(1):77-80
pubmed: 11734209
J Lipid Res. 2014 Apr;55(4):718-28
pubmed: 24489111
Biochemistry. 2005 May 31;44(21):7871-8
pubmed: 15910001
Cell Mol Life Sci. 2017 Aug;74(15):2815-2826
pubmed: 28299384
Circulation. 2009 Mar 24;119(11):1524-32
pubmed: 19273721
Biomed Res Int. 2015;2015:172801
pubmed: 26301243
Nucleic Acids Res. 1988 Feb 11;16(3):1215
pubmed: 3344216
Acta Neuropathol. 2011 Sep;122(3):271-83
pubmed: 21594711
Clin Epigenetics. 2016 Apr 05;8:37
pubmed: 27051467
Front Cell Neurosci. 2016 Dec 21;10:289
pubmed: 28066185
Curr Biol. 2014 Mar 31;24(7):786-92
pubmed: 24656827
J Proteome Res. 2014 May 2;13(5):2453-67
pubmed: 24601643
Brain Res. 2010 Mar 4;1317:218-26
pubmed: 20043896
Cell Rep. 2014 Oct 9;9(1):298-310
pubmed: 25284783
Epigenetics Chromatin. 2018 May 30;11(1):25
pubmed: 29848354
Leukemia. 2015 May;29(5):1202-6
pubmed: 25482132
J Alzheimers Dis. 2013;36(1):67-77
pubmed: 23524657
Mol Psychiatry. 2017 Mar;22(3):417-429
pubmed: 27457813
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
Acta Neuropathol. 2008 May;115(5):497-507
pubmed: 18365220
Nat Neurosci. 2014 Sep;17(9):1156-63
pubmed: 25129075
J Cell Biol. 2003 Apr 14;161(1):131-42
pubmed: 12695502
Mol Cancer. 2011 Sep 30;10:124
pubmed: 21962230
J Biol Chem. 2005 Jul 29;280(30):27809-14
pubmed: 15911621
JAMA Neurol. 2014 Apr;71(4):470-5
pubmed: 24566826
Genome Med. 2016 Jan 19;8(1):5
pubmed: 26803900
Dev Biol. 2012 Mar 1;363(1):95-105
pubmed: 22206757
PLoS One. 2018 Mar 19;13(3):e0194350
pubmed: 29554125
Hippocampus. 2014 Apr;24(4):363-8
pubmed: 24436131
Exp Neurobiol. 2015 Mar;24(1):8-16
pubmed: 25792865
Brain. 2009 May;132(Pt 5):1324-34
pubmed: 19321462
JAMA Neurol. 2015 Jan;72(1):15-24
pubmed: 25365775
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
J Neural Transm (Vienna). 2010 Dec;117(12):1387-93
pubmed: 21069393
J Cell Biol. 2006 Dec 18;175(6):869-80
pubmed: 17158953
Genomics. 1991 Aug;10(4):940-8
pubmed: 1916825
Alzheimers Dement. 2013 Jan;9(1):1-11.e3
pubmed: 23305821