Cerebrovascular disease: how serum phosphorus, vitamin D, and uric acid levels contribute to the ischemic stroke.
CVA
Iran
Ischemic
Phosphorus
Stroke
Uric acid
Vitamin D
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
31 Mar 2020
31 Mar 2020
Historique:
received:
09
07
2019
accepted:
12
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Associations between serum phosphorus level and the incidence of ischemic stroke are not clear. This study aimed to measure serum phosphorus, vitamin D3, and uric acid levels in ischemic stroke patients compared to a population without ischemic stroke. In this cross-sectional study, 133 patients admitted to a neurology ward with the diagnosis of ischemic stroke were compared with a control group comprising 133 age- and gender-matching individuals. The presence of ischemic stroke was confirmed by a neurologist based on clinical signs, symptoms, brain CT scan, and MRI. Blood samples were taken from all patients in the first 24 h of admission to measure serum phosphorus, vitamin D3, calcium, and uric acid levels. According to the results of this study, uric acid medians in patients with stroke and controls were 4.9 [3.8-6.4] and 3.9 [3.5-4.9] mg/dL, respectively (p < 0.001). Median phosphorus and vitamin D levels were significantly lower in stroke patients than the controls (3.6 [3.02-4.21] vs. 4.2 [3.8-4.6]) and (15.1 [8.2-27.9] vs. 22.7 [10.4-39.2]), respectively. Multiple logistic regression analysis showed that the ischemic stroke was positively associated with the vitamin D level and negatively correlated with the uric acid level. The phosphorus level was not significantly predictive of ischemic stroke. Lower serum levels of vitamin D3 and higher levels of uric acid were associated with ischemic stroke. There are still unknowns about the role of these indicators on ischemic stroke and it requires further studies.
Sections du résumé
BACKGROUND
BACKGROUND
Associations between serum phosphorus level and the incidence of ischemic stroke are not clear. This study aimed to measure serum phosphorus, vitamin D3, and uric acid levels in ischemic stroke patients compared to a population without ischemic stroke.
METHODS
METHODS
In this cross-sectional study, 133 patients admitted to a neurology ward with the diagnosis of ischemic stroke were compared with a control group comprising 133 age- and gender-matching individuals. The presence of ischemic stroke was confirmed by a neurologist based on clinical signs, symptoms, brain CT scan, and MRI. Blood samples were taken from all patients in the first 24 h of admission to measure serum phosphorus, vitamin D3, calcium, and uric acid levels.
RESULTS
RESULTS
According to the results of this study, uric acid medians in patients with stroke and controls were 4.9 [3.8-6.4] and 3.9 [3.5-4.9] mg/dL, respectively (p < 0.001). Median phosphorus and vitamin D levels were significantly lower in stroke patients than the controls (3.6 [3.02-4.21] vs. 4.2 [3.8-4.6]) and (15.1 [8.2-27.9] vs. 22.7 [10.4-39.2]), respectively. Multiple logistic regression analysis showed that the ischemic stroke was positively associated with the vitamin D level and negatively correlated with the uric acid level. The phosphorus level was not significantly predictive of ischemic stroke.
CONCLUSION
CONCLUSIONS
Lower serum levels of vitamin D3 and higher levels of uric acid were associated with ischemic stroke. There are still unknowns about the role of these indicators on ischemic stroke and it requires further studies.
Identifiants
pubmed: 32234035
doi: 10.1186/s12883-020-01686-4
pii: 10.1186/s12883-020-01686-4
pmc: PMC7110613
doi:
Substances chimiques
Vitamin D
1406-16-2
Uric Acid
268B43MJ25
Phosphorus
27YLU75U4W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116Références
Eur J Epidemiol. 2017 Jan;32(1):43-53
pubmed: 27300352
Ann Neurol. 2013 Jan;73(1):38-47
pubmed: 23225498
Am J Hum Genet. 2003 May;72(5):1154-61
pubmed: 12669274
Neuroepidemiology. 2015;45(3):161-76
pubmed: 26505981
Arch Intern Med. 2007 May 14;167(9):879-85
pubmed: 17502528
Cureus. 2017 Feb 17;9(2):e1038
pubmed: 28357170
Adv Nutr. 2013 Nov 06;4(6):723-9
pubmed: 24228204
Kidney Int. 2009 Jun;75(12):1297-1307
pubmed: 19322138
Arthritis Res Ther. 2012 Mar 10;14(2):R56
pubmed: 22405053
Stroke. 2016 Sep;47(9):2189-96
pubmed: 27507862
Annu Rev Med. 2010;61:91-104
pubmed: 20059333
Am J Clin Nutr. 2000 Nov;72(5 Suppl):1307S-1315S
pubmed: 11063473
J Am Soc Nephrol. 2009 Feb;20(2):397-404
pubmed: 18987306
Neurology. 2010 Jan 5;74(1):18-26
pubmed: 19940273
Clin J Am Soc Nephrol. 2009 Mar;4(3):609-15
pubmed: 19211667
Int J Cardiol. 2011 Jun 16;149(3):335-40
pubmed: 20189664
J Clin Endocrinol Metab. 2006 Aug;91(8):3144-9
pubmed: 16735491
Vet Pathol. 2015 Sep;52(5):770-84
pubmed: 26018436
Am J Clin Nutr. 2014 Sep;100(3):756-64
pubmed: 25030784
Am J Cardiol. 2010 Sep 15;106(6):793-7
pubmed: 20816119
Nat Rev Endocrinol. 2012 Jan 17;8(5):276-86
pubmed: 22249518
Circulation. 2000 Dec 5;102(23):2867-72
pubmed: 11104746
Int J Vitam Nutr Res. 2011 Jul;81(4):218-24
pubmed: 22237770
J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):387-92
pubmed: 15225806
Semin Nephrol. 2005 Jan;25(1):39-42
pubmed: 15660333
Osteoporos Int. 2007 Jan;18(1):59-68
pubmed: 17013567
Stroke. 2008 Sep;39(9):2611-3
pubmed: 18635847
N Engl J Med. 1980 Nov 27;303(22):1259-63
pubmed: 6999353
Circulation. 2005 Oct 25;112(17):2627-33
pubmed: 16246962
Am Heart J. 2008 Sep;156(3):556-63
pubmed: 18760141
PLoS One. 2013;8(3):e58348
pubmed: 23505492
Matrix Biol. 2004 Nov;23(7):421-32
pubmed: 15579309
Arterioscler Thromb Vasc Biol. 2013 May;33(5):1070-6
pubmed: 23430618
Am J Clin Nutr. 2010 Jan;91(1):82-9
pubmed: 19906799