Calcinosis Biomarkers in Adult and Juvenile Dermatomyositis.
Autoantibodies
Calcinosis
Dermatoyositis
Journal
Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
09
12
2019
accepted:
13
12
2019
pubmed:
3
4
2020
medline:
11
8
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by muscle weakness and cutaneous manifestations in adults and children. Calcinosis, a complication of DM, is the abnormal deposition of insoluble calcium salts in tissues, including skin, subcutaneous tissue, tendons, fascia, and muscle. Calcinosis is more commonly seen in juvenile DM (JDM), but also develops in adult DM. Although the mechanism of calcinosis remains unclear, several pathogenic hypotheses have been proposed, including intracellular accumulation of calcium secondary to an alteration of the cellular membrane by trauma and inflammation, local vascular ischemia, dysregulation of mechanisms controlling the deposition and solubility of calcium and phosphate, and mitochondrial damage of muscle cells. Identifying calcinosis biomarkers is important for early disease detection and risk assessment, and may lead to novel therapeutic targets for the prevention and treatment of DM-associated calcinosis. In this review, we summarize myositis autoantibodies associated with calcinosis in DM, histopathology and chemical composition of calcinosis, genetic and inflammatory markers that have been studied in adult DM and JDM-associated calcinosis, as well as potential novel biomarkers.
Identifiants
pubmed: 32234404
pii: S1568-9972(20)30088-4
doi: 10.1016/j.autrev.2020.102533
pmc: PMC7225028
mid: NIHMS1570109
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102533Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR050942
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES101074
Pays : United States
Informations de copyright
Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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