Nucleolin and Nucleophosmin Expression in Gleason 3 and Gleason 4 Prostate Cancer With Seminal Vesicles Invasion (pT3b).
Adenocarcinoma
/ epidemiology
Aged
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
/ genetics
Nuclear Proteins
/ genetics
Nucleophosmin
Phosphoproteins
/ genetics
Prognosis
Prostate
/ pathology
Prostate-Specific Antigen
/ genetics
Prostatectomy
Prostatic Neoplasms
/ epidemiology
RNA-Binding Proteins
/ genetics
Seminal Vesicles
/ pathology
Nucleolin
Gleason grade
Nucleolar proteins
local spread
neoplasm invasiveness
prostate cancer
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
24
02
2020
revised:
09
03
2020
accepted:
10
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
10
4
2020
Statut:
ppublish
Résumé
The aim of this study was to analyze the expression of nucleolin (NCL) and nucleophosmin (NPM) in prostate adenocarcinoma and in its loco-regional spread in the form of seminal vesicle invasion (SVI). The study was performed on tissue microarrays of 40 cases of Gleason 3+4 pT3b prostate cancers including tissue samples from SVI. The expression of NCL and NPM was detected immunohistochemically and analyzed with image analysis software. The expression of NCL and NPM were higher in cancer cells within a prostate gland than in SVI. Gleason 4 pattern showed higher expression of NPM than Gleason 3 pattern cells. Differences in nuclear NCL and NPM expression in cancer cells between the prostate gland and SVI may indicate involvement of these proteins in loco-regional spread of adenocarcinoma of the prostate. Differences in NPM expression in Gleason 3 and Gleason 4 pattern suggest involvement of this protein in the differentiation of prostate cancer.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The aim of this study was to analyze the expression of nucleolin (NCL) and nucleophosmin (NPM) in prostate adenocarcinoma and in its loco-regional spread in the form of seminal vesicle invasion (SVI).
MATERIALS AND METHODS
METHODS
The study was performed on tissue microarrays of 40 cases of Gleason 3+4 pT3b prostate cancers including tissue samples from SVI. The expression of NCL and NPM was detected immunohistochemically and analyzed with image analysis software.
RESULTS
RESULTS
The expression of NCL and NPM were higher in cancer cells within a prostate gland than in SVI. Gleason 4 pattern showed higher expression of NPM than Gleason 3 pattern cells.
CONCLUSION
CONCLUSIONS
Differences in nuclear NCL and NPM expression in cancer cells between the prostate gland and SVI may indicate involvement of these proteins in loco-regional spread of adenocarcinoma of the prostate. Differences in NPM expression in Gleason 3 and Gleason 4 pattern suggest involvement of this protein in the differentiation of prostate cancer.
Identifiants
pubmed: 32234886
pii: 40/4/1973
doi: 10.21873/anticanres.14152
doi:
Substances chimiques
NPM1 protein, human
0
Nuclear Proteins
0
Phosphoproteins
0
RNA-Binding Proteins
0
Nucleophosmin
117896-08-9
Prostate-Specific Antigen
EC 3.4.21.77
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1973-1979Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.