Epidemiological Correlations Between Head and Neck Cancer and Hepatitis B Core Antibody Positivity.
Aged
Case-Control Studies
Comorbidity
Female
Head and Neck Neoplasms
/ diagnosis
Hepatitis B
/ epidemiology
Hepatitis B Antibodies
/ immunology
Hepatitis B Core Antigens
/ immunology
Hepatitis B Surface Antigens
/ immunology
Hepatitis B virus
/ immunology
Humans
Japan
/ epidemiology
Male
Middle Aged
Retrospective Studies
Risk Factors
HBc antibody
Hepatitis B virus
head and neck cancer
multivariate analysis
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
28
02
2020
revised:
17
03
2020
accepted:
18
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
21
4
2020
Statut:
ppublish
Résumé
Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. HBc antibody positivity and HNC are epidemiologically correlated.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection.
PATIENTS AND METHODS
METHODS
We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects.
RESULTS
RESULTS
Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group.
CONCLUSION
CONCLUSIONS
HBc antibody positivity and HNC are epidemiologically correlated.
Identifiants
pubmed: 32234943
pii: 40/4/2393
doi: 10.21873/anticanres.14209
doi:
Substances chimiques
Hepatitis B Antibodies
0
Hepatitis B Core Antigens
0
Hepatitis B Surface Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2393-2403Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.