Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid.
antifungal drugs
clotrimazole
design of experiments
hexadecyl amine
hyaluronic acid
ionic polymeric micelles
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
29 Mar 2020
29 Mar 2020
Historique:
received:
28
02
2020
revised:
25
03
2020
accepted:
26
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
3
4
2020
Statut:
epublish
Résumé
Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core-shell" structure. Previously, ionic polymeric micelles based on chitosan and fatty acids have been developed. The aim of the present study was the preparation and characterization of hyaluronic acid (HA) derivatives by direct ionic interaction between the HA carboxylic groups and the amine groups of dodecyl amine (DDA) and hexadecyl amine (HDA). The HA-HDA polymeric micelles were loaded with a poorly soluble hydrophobic antifungal drug, clotrimazole (CLO). A 2
Identifiants
pubmed: 32235344
pii: nano10040635
doi: 10.3390/nano10040635
pmc: PMC7221810
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Mol Pharm. 2015 May 4;12(5):1391-401
pubmed: 25871518
Res Pharm Sci. 2019 Aug;14(4):293-307
pubmed: 31516506
Carbohydr Polym. 2020 Feb 15;230:115608
pubmed: 31887870
Eur J Pharm Sci. 2017 Mar 1;99:285-291
pubmed: 28057549
Eur J Pharm Biopharm. 2014 Nov;88(3):643-50
pubmed: 25128852
Int J Pharm. 2011 Nov 25;420(1):1-10
pubmed: 21884771
Eur J Cell Biol. 2006 Aug;85(8):699-715
pubmed: 16822580
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:1327-1340
pubmed: 28532010
Drug Deliv. 2018 Nov;25(1):132-142
pubmed: 29275642
Int J Pharm. 2014 Nov 20;475(1-2):163-73
pubmed: 25148729
Eur J Pharm Biopharm. 2014 May;87(1):101-6
pubmed: 24384070
J Control Release. 2017 Aug 28;260:213-225
pubmed: 28625671
Carbohydr Polym. 2017 Jan 20;156:86-96
pubmed: 27842856
Int J Biol Macromol. 2019 Oct 1;138:636-647
pubmed: 31330211
Carbohydr Polym. 2018 Feb 15;182:132-141
pubmed: 29279107
J Control Release. 2017 Jun 28;256:9-18
pubmed: 28414149
Eur J Pharm Sci. 2020 Feb 15;143:105168
pubmed: 31783157
Biomaterials. 2010 Jan;31(1):106-14
pubmed: 19783037
J Biomed Nanotechnol. 2016 Jan;12(1):231-40
pubmed: 27301186
Int J Cosmet Sci. 2006 Oct;28(5):359-70
pubmed: 18489300
Int J Pharm. 2014 May 15;466(1-2):147-55
pubmed: 24614580
BMC Microbiol. 2019 Jan 14;19(1):13
pubmed: 30642259
Eur J Pharm Biopharm. 2015 Nov;97(Pt B):400-16
pubmed: 26614559
Adv Drug Deliv Rev. 2016 Feb 1;97:204-36
pubmed: 26592477