Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning.
bioinformatics analysis
cancer
chaperone
co-expression
mitochondria
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Mar 2020
30 Mar 2020
Historique:
received:
17
02
2020
revised:
20
03
2020
accepted:
25
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
3
4
2020
Statut:
epublish
Résumé
Metabolic reprogramming is a hallmark of cancer. Such reprogramming entails the up-regulation of the expression of specific mitochondrial proteins, thus increasing the burden on the mitochondrial protein quality control. However, very little is known about the specificity of interactions between mitochondrial chaperones and their clients, or to what extent the mitochondrial chaperone-client co-expression is coordinated. We hypothesized that a physical interaction between a chaperone and its client in mitochondria ought to be manifested in the co-expression pattern of both transcripts. Using The Cancer Genome Atlas (TCGA) gene expression data from 13 tumor entities, we constructed the mitochondrial chaperone-client co-expression network. We determined that the network is comprised of three distinct modules, each populated with unique chaperone-clients co-expression pairs belonging to distinct functional groups. Surprisingly, chaperonins
Identifiants
pubmed: 32235444
pii: cancers12040825
doi: 10.3390/cancers12040825
pmc: PMC7226338
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Israel Science Foundation
ID : 1436/19
Organisme : German Cancer Aid
ID : DKH-70112257
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG-391665916
Références
Cell. 2008 Jul 11;134(1):112-23
pubmed: 18614015
Nature. 2014 Apr 3;508(7494):108-12
pubmed: 24670634
Acta Neuropathol. 2013 Aug;126(2):277-89
pubmed: 23689617
PLoS Biol. 2018 Jan 25;16(1):e2003992
pubmed: 29370167
Cell. 2014 Dec 18;159(7):1603-14
pubmed: 25525878
Nature. 2016 Apr 14;532(7598):255-8
pubmed: 27049945
Mol Cancer. 2011 Oct 11;10:128
pubmed: 21988793
Cancer Res. 2010 Nov 15;70(22):8988-93
pubmed: 20978188
Nat Commun. 2018 Jun 27;9(1):2500
pubmed: 29950559
FEBS Lett. 2014 Aug 1;588(15):2496-503
pubmed: 24911204
Cancer Res. 2005 Feb 1;65(3):999-1006
pubmed: 15705901
Science. 2002 Jan 25;295(5555):669-71
pubmed: 11809970
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
Nat Commun. 2017 May 11;8:15267
pubmed: 28492237
Nature. 2019 Feb;566(7744):403-406
pubmed: 30728499
PLoS Genet. 2016 Dec 30;12(12):e1006531
pubmed: 28036392
Cell. 2007 Oct 19;131(2):257-70
pubmed: 17956728
Oncogene. 2019 Apr;38(14):2464-2481
pubmed: 30532069
Nature. 2019 Apr;568(7750):117-121
pubmed: 30814728
Oncotarget. 2012 Nov;3(11):1272-83
pubmed: 23174755
Nat Chem Biol. 2015 Jan;11(1):9-15
pubmed: 25517383
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1511-6
pubmed: 9465046
Cancer Discov. 2015 Oct;5(10):1024-39
pubmed: 26382145
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W245-52
pubmed: 17576675
Biochim Biophys Acta. 2013 Feb;1833(2):388-99
pubmed: 22705353
Nat Commun. 2014 Jun 11;5:4114
pubmed: 24916345
Cell. 2009 Aug 21;138(4):628-44
pubmed: 19703392
Cancers (Basel). 2019 Jan 30;11(2):
pubmed: 30704052
Cell. 2016 Jul 28;166(3):555-566
pubmed: 27471965
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):972-7
pubmed: 23277563
Cancer Res. 2015 Feb 1;75(3):554-65
pubmed: 25511375
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9433-9442
pubmed: 31000598
Cancer Cell. 2012 Oct 16;22(4):425-37
pubmed: 23079654
Nat Med. 2015 Jun;21(6):638-46
pubmed: 26005855
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8788-93
pubmed: 20421486
G3 (Bethesda). 2012 Sep;2(9):987-1002
pubmed: 22973536
Nat Genet. 2015 Dec;47(12):1475-81
pubmed: 26482881
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Nature. 2015 Nov 12;527(7577):186-91
pubmed: 26466563
Cell Metab. 2015 Jan 6;21(1):81-94
pubmed: 25565207
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1118-23
pubmed: 18216267
Nature. 2009 Sep 3;461(7260):109-13
pubmed: 19693011
Nucleic Acids Res. 2016 Jan 4;44(D1):D1251-7
pubmed: 26450961
J Anim Ecol. 2010 Jul;79(4):811-7
pubmed: 20374411
Nat Rev Cancer. 2010 Apr;10(4):267-77
pubmed: 20300106
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9383-7
pubmed: 12881488
Oncotarget. 2013 Dec;4(12):2577-90
pubmed: 24342878
Nucleic Acids Res. 2005 Jun 02;33(10):3154-64
pubmed: 15933209
EMBO J. 1998 Oct 15;17(20):5868-76
pubmed: 9774331
Cancer Cell. 2013 Sep 9;24(3):379-93
pubmed: 24029234
Nat Rev Drug Discov. 2016 Jun;15(6):385-403
pubmed: 26775688
Nat Rev Cancer. 2017 May;17(5):302-317
pubmed: 28303905
Cell Death Differ. 2012 Mar;19(3):501-10
pubmed: 21941369
Nat Rev Cancer. 2012 Oct;12(10):685-98
pubmed: 23001348
Cell Death Dis. 2019 Mar 13;10(3):246
pubmed: 30867410
EMBO J. 1999 Feb 1;18(3):717-26
pubmed: 9927431
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683