Acute Kidney Injury Patterns Following Transplantation of Steatotic Liver Allografts.
acute kidney injury
allograft steatosis
lipopeliosis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
30 Mar 2020
30 Mar 2020
Historique:
received:
29
02
2020
revised:
23
03
2020
accepted:
27
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
3
4
2020
Statut:
epublish
Résumé
Steatotic grafts are increasingly being used for liver transplant (LT); however, the impact of graft steatosis on renal function has not been well described. A total of 511 allografts from Mayo Clinic Arizona and Minnesota were assessed. We evaluated post-LT acute kidney injury (AKI) patterns, perioperative variables and one-year outcomes for patients receiving moderately steatotic allografts (>30% macrovesicular steatosis, Post-LT AKI occurred in 52.5% of steatotic graft recipients versus 16.7% in non-steatotic recipients ( One-year outcomes for moderately steatotic grafts are satisfactory; however, a higher percentage of post-LT AKI and initiation of dialysis can be expected. Presence of lipopeliosis on biopsy appears to be predictive of post-LT AKI.
Sections du résumé
BACKGROUND
BACKGROUND
Steatotic grafts are increasingly being used for liver transplant (LT); however, the impact of graft steatosis on renal function has not been well described.
METHODS
METHODS
A total of 511 allografts from Mayo Clinic Arizona and Minnesota were assessed. We evaluated post-LT acute kidney injury (AKI) patterns, perioperative variables and one-year outcomes for patients receiving moderately steatotic allografts (>30% macrovesicular steatosis,
RESULTS
RESULTS
Post-LT AKI occurred in 52.5% of steatotic graft recipients versus 16.7% in non-steatotic recipients (
CONCLUSION
CONCLUSIONS
One-year outcomes for moderately steatotic grafts are satisfactory; however, a higher percentage of post-LT AKI and initiation of dialysis can be expected. Presence of lipopeliosis on biopsy appears to be predictive of post-LT AKI.
Identifiants
pubmed: 32235545
pii: jcm9040954
doi: 10.3390/jcm9040954
pmc: PMC7230326
pii:
doi:
Types de publication
Journal Article
Langues
eng
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