Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells.
LMNA gene
cellular migration
lamin A
osteoblast differentiation
osteosarcoma
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
22 03 2020
22 03 2020
Historique:
received:
03
01
2020
revised:
16
03
2020
accepted:
19
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
11
2
2021
Statut:
epublish
Résumé
A type lamins are fundamental components of the nuclear lamina. Changes in lamin A expression correlate with malignant transformation in several cancers. However, the role of lamin A has not been explored in osteosarcoma (OS). Here, we wanted to investigate the role of lamin A in normal osteoblasts (OBs) and OS cells. Thus, we studied the expression of lamin A/C in OS cells compared to OBs and evaluated the effects of lamin A overexpression in OS cell lines. We show that, while lamin A expression increases during osteoblast differentiation, all examined OS cell lines express lower lamin A levels relative to differentiated OBs. The condition of low
Identifiants
pubmed: 32235738
pii: cells9030774
doi: 10.3390/cells9030774
pmc: PMC7140691
pii:
doi:
Substances chimiques
Lamin Type A
0
prelamin A
0
Lovastatin
9LHU78OQFD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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