Reciprocal regulation between alternative splicing and the DNA damage response.
Journal
Genetics and molecular biology
ISSN: 1415-4757
Titre abrégé: Genet Mol Biol
Pays: Brazil
ID NLM: 100883590
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
04
2019
accepted:
16
12
2019
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
3
4
2020
Statut:
epublish
Résumé
Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing which, in a reciprocal way, shapes the response to a damaging agent.
Identifiants
pubmed: 32236390
pii: S1415-47572020000200310
doi: 10.1590/1678-4685-GMB-2019-0111
pmc: PMC7197977
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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