Pharmacokinetics and Drug Residue in Eggs After Multiple-Day Oral Dosing of Amoxicillin-Clavulanic Acid in Domestic Chickens.
Clavamox
amoxicillin
avian
backyard poultry
clavulanic acid
domestic chicken
drug residue
egg withdrawal
pharmacokinetics
Journal
Journal of avian medicine and surgery
ISSN: 1082-6742
Titre abrégé: J Avian Med Surg
Pays: United States
ID NLM: 9512497
Informations de publication
Date de publication:
29 Mar 2020
29 Mar 2020
Historique:
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
This study examined the pharmacokinetics of orally administered amoxicillin and clavulanic acid tablets (Clavamox, 125 mg/kg PO q12h for 9 doses) in domestic hens and examined both amoxicillin and clavulanic acid concentrations in eggs. Therapeutic plasma concentrations (0.5 µg/mL) of amoxicillin were not reached at any time point, and no amoxicillin was detected in plasma after 2 hours. Pharmacokinetic parameters could not be calculated. The clavulanic acid half-life was 1.1 hours and it was detected up to 8 hours after dosing. No amoxicillin was detected in eggs 4 days postdosing, nor was clavulanic acid detected in any eggs during the same time period. On the basis of these results, orally dosing hens with amoxicillin and clavulanic acid tablets at 125 mg/kg PO q12h does not reach therapeutic plasma concentrations. Additional studies are needed to examine different doses and formulations of medication to determine better dosing and withdrawal recommendations for domestic chickens.
Identifiants
pubmed: 32237676
doi: 10.1647/1082-6742-34.1.3
doi:
Substances chimiques
Anti-Bacterial Agents
0
Amoxicillin-Potassium Clavulanate Combination
74469-00-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-8Références
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