Low-Energy Shockwave Treatment Promotes Endothelial Progenitor Cell Homing to the Stenotic Pig Kidney.
capillary
endothelial progenitor cells
low-energy shockwave
renal artery stenosis
Journal
Cell transplantation
ISSN: 1555-3892
Titre abrégé: Cell Transplant
Pays: United States
ID NLM: 9208854
Informations de publication
Date de publication:
Historique:
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
9
6
2021
Statut:
ppublish
Résumé
Endothelial progenitor cells (EPCs) patrols the circulation and contributes to endothelial cell regeneration. Atherosclerotic renal artery stenosis (ARAS) induces microvascular loss in the stenotic kidney (STK). Low-energy shockwave therapy (SW) can induce angiogenesis and restore the STK microcirculation, but the underlying mechanism remains unclear. We tested the hypothesis that SW increases EPC homing to the swine STK, associated with capillary regeneration. Normal pigs and pigs after 3 wk of renal artery stenosis were treated with six sessions of low-energy SW (biweekly for three consecutive weeks) or left untreated. Four weeks after completion of treatment, we assessed EPC (CD34+/KDR+) numbers and levels of the homing-factor stromal cell-derived factor (SDF)-1 in the inferior vena cava and the STK vein and artery, as well as urinary levels of vascular endothelial growth factor (VEGF) and integrin-1β. Subsequently, we assessed STK morphology, capillary count, and expression of the proangiogenic growth factors angiopoietin-1, VEGF, and endothelial nitric oxide synthase
Identifiants
pubmed: 32237997
doi: 10.1177/0963689720917342
pmc: PMC7444225
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
963689720917342Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL123160
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122734
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK104273
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102325
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120292
Pays : United States
Références
Pediatr Nephrol. 2014 Mar;29(3):333-42
pubmed: 23475077
Oncogene. 2019 Feb;38(7):1050-1066
pubmed: 30194450
Clin J Sport Med. 2017 Sep;27(5):430-437
pubmed: 27893487
Circulation. 2006 Dec 19;114(25):2823-30
pubmed: 17145991
J Wound Care. 2018 Sep 2;27(9):573-583
pubmed: 30204576
J Tissue Eng Regen Med. 2017 Nov;11(11):3241-3252
pubmed: 27943613
Hypertension. 2007 Oct;50(4):729-36
pubmed: 17635852
Ultrasound Med Biol. 2017 Jan;43(1):362-369
pubmed: 27745716
Am J Transl Res. 2011 May 15;3(3):259-68
pubmed: 21633631
J Am Soc Nephrol. 2017 Nov;28(11):3251-3261
pubmed: 28696247
Microvasc Res. 2018 Jul;118:49-56
pubmed: 29476756
J Am Soc Nephrol. 2016 Dec;27(12):3715-3724
pubmed: 27297945
Br J Sports Med. 2018 Mar;52(6):387-407
pubmed: 28954794
J Inflamm (Lond). 2018 May 16;15:10
pubmed: 29796010
J Thorac Cardiovasc Surg. 2013 Oct;146(4):971-8
pubmed: 23395097
Eur J Surg Oncol. 2018 Apr;44(4):496-501
pubmed: 29397265
Wound Repair Regen. 2012 Nov-Dec;20(6):887-95
pubmed: 23110611
Ann Surg. 2011 May;253(5):1024-32
pubmed: 21372687
Circ Cardiovasc Interv. 2012 Oct;5(5):720-8
pubmed: 23048054
J Am Soc Nephrol. 1999 Jul;10(7):1455-65
pubmed: 10405201
Nephrology (Carlton). 2018 May;23(5):411-417
pubmed: 28240799
Stem Cells. 2010 Jun;28(6):1039-47
pubmed: 20506499
Stem Cells. 2018 Dec;36(12):1863-1874
pubmed: 30171660
Mayo Clin Proc. 2014 Mar;89(3):346-54
pubmed: 24582193
FASEB J. 2015 Jul;29(7):3085-99
pubmed: 25854700
N Engl J Med. 2014 Jan 2;370(1):13-22
pubmed: 24245566
Curr Hypertens Rep. 2018 Apr 10;20(4):35
pubmed: 29637445
Curr Opin Nephrol Hypertens. 2009 Mar;18(2):160-5
pubmed: 19430335
Biochem Biophys Res Commun. 2017 Nov 4;493(1):64-70
pubmed: 28919424
Cardiovasc Revasc Med. 2015 Jan-Feb;16(1):6-11
pubmed: 25555620
Ann Vasc Surg. 2019 Apr;56:330-339
pubmed: 30496896
J Am Heart Assoc. 2018 Oct 16;7(20):e010025
pubmed: 30371289
Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F273-9
pubmed: 26041447
Sci Rep. 2018 Sep 17;8(1):13948
pubmed: 30224726
JAMA. 2013 Apr 17;309(15):1622-31
pubmed: 23592107
Int J Impot Res. 2019 May;31(3):204-205
pubmed: 30254306
Coron Artery Dis. 2015 May;26(3):194-200
pubmed: 25734606