Blunting senescence boosts liver regeneration.

Animals Hepatectomy Hepatocytes Liver Liver Regeneration Mice
ABT-737 aging hepatocyte liver regeneration p16Ink4a p21 senescence senolytic

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 04 2020
Historique:
entrez: 3 4 2020
pubmed: 3 4 2020
medline: 21 7 2020
Statut: ppublish

Résumé

The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of

Identifiants

DOI: 10.1101/gad.337394.120 PMID: 32238449 PMC: PMC7111267
pubmed: 32238449
pii: 34/7-8/463
doi: 10.1101/gad.337394.120
pmc: PMC7111267
doi:

Types de publication

Journal Article Review Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

463-464

Subventions

Organisme : Medical Research Council
ID : MC_U120085810
Pays : United Kingdom

Commentaires et corrections

Type : CommentOn

Informations de copyright

© 2020 Birch and Gil; Published by Cold Spring Harbor Laboratory Press.

Références

Sci Transl Med. 2018 Aug 15;10(454):
pubmed: 30111642
Cell. 2008 Aug 22;134(4):657-67
pubmed: 18724938
Aging Cell. 2015 Aug;14(4):644-58
pubmed: 25754370
Nature. 2018 Oct;562(7728):578-582
pubmed: 30232451
Nat Commun. 2017 Jun 13;8:15691
pubmed: 28608850
J Clin Invest. 2018 Apr 2;128(4):1238-1246
pubmed: 29608137
Nature. 2016 Feb 11;530(7589):184-9
pubmed: 26840489
J Cell Biol. 2018 Jan 2;217(1):65-77
pubmed: 29114066
Genes Dev. 2020 Apr 1;34(7-8):489-494
pubmed: 32139422

Auteurs

Jodie Birch (J)

MRC London Institute of Medical Sciences, London W12 0NN, United Kingdom.
Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.

Jesus Gil (J)

MRC London Institute of Medical Sciences, London W12 0NN, United Kingdom.
Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.
ORCID: 0000-0002-4303-6260

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Blunting senescence boosts liver regeneration.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie digestive › Hépatectomie › Blunting senescence boosts liver regeneration.
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Blunting senescence boosts liver regeneration.
questionsmedicales.fr › Système digestif › Foie › Blunting senescence boosts liver regeneration.
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération hépatique › Blunting senescence boosts liver regeneration.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Blunting senescence boosts liver regeneration.