biomarkers, tumor
gastrointestinal neoplasms
genome instability
immunotherapy
Journal
Journal for immunotherapy of cancer
ISSN: 2051-1426
Titre abrégé: J Immunother Cancer
Pays: England
ID NLM: 101620585
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
accepted:
03
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
1
9
2021
Statut:
ppublish
Résumé
Immunological checkpoint blockade is effective in treating various malignancies. Identifying predictive biomarkers to assist patient selection for immunotherapy has become a priority in both clinical and research settings. Mutations in patients who responded to immunotherapy were identified through next-generation sequencing. Relationships among protein kinase, DNA-activated, catalytic polypeptide ( From the published literature, we found that among patients whose tumors harbored PRKDC is not only a predictive biomarker but also a drug target for immune checkpoint inhibitors.
Sections du résumé
BACKGROUND
Immunological checkpoint blockade is effective in treating various malignancies. Identifying predictive biomarkers to assist patient selection for immunotherapy has become a priority in both clinical and research settings.
METHODS
Mutations in patients who responded to immunotherapy were identified through next-generation sequencing. Relationships among protein kinase, DNA-activated, catalytic polypeptide (
RESULTS
From the published literature, we found that among patients whose tumors harbored
CONCLUSIONS
PRKDC is not only a predictive biomarker but also a drug target for immune checkpoint inhibitors.
Identifiants
pubmed: 32238472
pii: jitc-2019-000485
doi: 10.1136/jitc-2019-000485
pmc: PMC7174075
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: KTT, J-HC and S-JC are employees of ACT genomics. DS-SH is an employee of Asclepiumm Taiwan Com.
Références
Annu Rev Biochem. 2010;79:181-211
pubmed: 20192759
Lancet. 2017 Jun 24;389(10088):2492-2502
pubmed: 28434648
Blood. 2017 May 4;129(18):2471-2478
pubmed: 28270452
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8
pubmed: 15980494
Nature. 2005 Apr 14;434(7035):917-21
pubmed: 15829967
Nat Methods. 2015 May;12(5):453-7
pubmed: 25822800
ChemMedChem. 2017 Jun 21;12(12):895-900
pubmed: 28423228
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Oncogene. 2006 Mar 30;25(14):2113-8
pubmed: 16288216
N Engl J Med. 2015 Oct 22;373(17):1627-39
pubmed: 26412456
Cancer Discov. 2017 Mar;7(3):264-276
pubmed: 28031159
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Cancer Discov. 2014 Oct;4(10):1126-39
pubmed: 25168287
N Engl J Med. 2016 Nov 10;375(19):1856-1867
pubmed: 27718784
N Engl J Med. 2014 Dec 4;371(23):2189-2199
pubmed: 25409260
Lancet Oncol. 2016 Jun;17(6):717-726
pubmed: 27157491
Clin Cancer Res. 2016 Feb 15;22(4):813-20
pubmed: 26880610
Science. 2018 Feb 16;359(6377):801-806
pubmed: 29301960
Cell. 2017 Nov 2;171(4):934-949.e16
pubmed: 29033130
Science. 2015 Apr 3;348(6230):124-8
pubmed: 25765070
Science. 2015 Oct 9;350(6257):207-211
pubmed: 26359337
Oncotarget. 2016 Apr 26;7(17):23312-21
pubmed: 27004405
Sci Rep. 2015 Aug 26;5:13321
pubmed: 26306458
World J Surg. 2012 Sep;36(9):2131-8
pubmed: 22669398
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Nucleic Acids Res. 2002 Sep 1;30(17):3894-900
pubmed: 12202775
Cancer Res Treat. 2005 Apr;37(2):98-102
pubmed: 19956487
Int J Oncol. 2007 Oct;31(4):859-66
pubmed: 17786318
Clin Cancer Res. 2016 Sep 1;22(17):4309-21
pubmed: 27390348
Cancer Res. 2001 Apr 15;61(8):3230-9
pubmed: 11309271
Cancer Immunol Immunother. 2012 Jul;61(7):1019-31
pubmed: 22146893
Science. 1974 Sep 6;185(4154):862-4
pubmed: 4843792
Science. 2015 Apr 3;348(6230):69-74
pubmed: 25838375
Lancet. 2017 Jan 7;389(10064):67-76
pubmed: 27939400
Carcinogenesis. 2008 Apr;29(4):673-80
pubmed: 17942460
Nat Protoc. 2009;4(7):1073-81
pubmed: 19561590
Nat Rev Clin Oncol. 2010 Mar;7(3):153-62
pubmed: 20142816