Geriatric Nutritional Risk Index (GNRI) and Creatinine Index Equally Predict the Risk of Mortality in Hemodialysis Patients: J-DOPPS.
Aged
Aged, 80 and over
Creatinine
/ blood
Female
Geriatric Assessment
Humans
Japan
/ epidemiology
Kidney Failure, Chronic
/ blood
Male
Middle Aged
Nutrition Assessment
Nutritional Status
Prognosis
Proportional Hazards Models
Prospective Studies
Renal Dialysis
/ mortality
Risk Assessment
Risk Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
22
02
2019
accepted:
11
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The geriatric nutritional risk index (GNRI) and creatinine (Cr) index are indexes often used as nutritional surrogates in patients receiving hemodialysis. However, few studies have directly compared the clinical characteristics of these two indexes. We investigated 3,536 hemodialysis patients enrolled in the Japan DOPPS phases 4 and 5. The primary outcome was all-cause mortality and the main exposures were the GNRI and Cr index. We confirmed and compared the association between these indexes and mortality risk as estimated by a multivariable-adjusted Cox proportional hazards model. During the median 2.2-year follow-up period, 414 patients died of any cause. In the multivariable-adjusted model, lower GNRI and Cr index were both associated with increased risk of all-cause mortality, and these associations were further confirmed by restricted cubic spline curves. The predictability of all-cause mortality, as represented by the c-statistic, was comparable between the two indexes. Furthermore, baseline nutritional surrogates that corresponded with lower GNRI or Cr index values were comparable between the two indexes. Given that calculating the GNRI is simpler than calculating the Cr index, our data suggest that the GNRI may be preferable to the Cr index for predicting clinical outcomes in patients undergoing maintenance hemodialysis.
Identifiants
pubmed: 32238848
doi: 10.1038/s41598-020-62720-6
pii: 10.1038/s41598-020-62720-6
pmc: PMC7113241
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5756Références
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