Production of immunogenic recombinant L1 protein of bovine papillomavirus type 9 causing teat papillomatosis.
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
03
12
2019
accepted:
06
03
2020
pubmed:
3
4
2020
medline:
28
5
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
Bovine papillomavirus type 9 (BPV9) is a causative agent of severe teat papillomatosis. Considering the lack of efficient BPV culture methods, recombinant proteins such as virus-like particles developed through genetic engineering may serve as a useful tool for developing effective vaccines against BPV infection. In this study, we successfully produced immunogenic particles composed of recombinant L1 protein of BPV9 (rBPV9-L1), using a baculovirus expression system. rBPV9-L1-immunized mice produced BPV9-specific IgG, which did not cross-react with BPV type 6, which is another causative agent of teat papillomatosis. Hence, immunogenic rBPV9-L1 is potentially applicable as a vaccine candidate for teat papillomatosis.
Identifiants
pubmed: 32239294
doi: 10.1007/s00705-020-04612-8
pii: 10.1007/s00705-020-04612-8
doi:
Substances chimiques
Capsid Proteins
0
L1 protein, Bovine papillomavirus
0
Recombinant Proteins
0
Vaccines, Virus-Like Particle
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM