Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia.
Chronic pain
Cutaneous mechanical allodynia
Dorsal horn
Neurons
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
26
11
2019
accepted:
10
02
2020
pubmed:
3
4
2020
medline:
16
6
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. These approaches have led to the discovery of several molecularly defined cell types that have been implicated in cutaneous mechanical allodynia, a highly prevalent and difficult-to-treat symptom of chronic pain, in which touch becomes painful. The main objective of this review is to provide a contemporary view of dorsal horn neuronal populations, and describe recent advances in our understanding of on how they participate in cutaneous mechanical allodynia.
Identifiants
pubmed: 32239353
doi: 10.1007/s00702-020-02159-1
pii: 10.1007/s00702-020-02159-1
pmc: PMC7148279
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
505-525Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S002987/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102645
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N006119/1
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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