Genomic Alterations and MYD88
Journal
Targeted oncology
ISSN: 1776-260X
Titre abrégé: Target Oncol
Pays: France
ID NLM: 101270595
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
3
4
2020
medline:
15
12
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous malignancy. Following front-line immunochemotherapy, 30-40% of DLBCL patients develop relapsed or refractory (r/r) disease, which can be treated with ibrutinib. It has been previously reported that MYD88 Here, we aimed to gather understanding of MYD88 In this study, tissue samples from DLBCL patients (n = 212) were retrospectively collected and sequenced by target-capturing panels of either 413 or 112 genes that are frequently mutated in non-Hodgkin's lymphoma. Sixty patients with MYD88 mutations and available clinical information were included for further analysis. Seven MYD88 This study adds clinical observations with MYD88
Sections du résumé
BACKGROUND
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous malignancy. Following front-line immunochemotherapy, 30-40% of DLBCL patients develop relapsed or refractory (r/r) disease, which can be treated with ibrutinib. It has been previously reported that MYD88
OBJECTIVE
Here, we aimed to gather understanding of MYD88
PATIENTS AND METHODS
In this study, tissue samples from DLBCL patients (n = 212) were retrospectively collected and sequenced by target-capturing panels of either 413 or 112 genes that are frequently mutated in non-Hodgkin's lymphoma. Sixty patients with MYD88 mutations and available clinical information were included for further analysis.
RESULTS
Seven MYD88
CONCLUSIONS
This study adds clinical observations with MYD88
Identifiants
pubmed: 32239385
doi: 10.1007/s11523-020-00710-4
pii: 10.1007/s11523-020-00710-4
doi:
Substances chimiques
MYD88 protein, human
0
Myeloid Differentiation Factor 88
0
Piperidines
0
Pyrazoles
0
Pyrimidines
0
ibrutinib
1X70OSD4VX
Adenine
JAC85A2161
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-230Subventions
Organisme : National Key Technology Support Program
ID : 2014BAI09B12
Pays : International
Organisme : National New Drug Innovation Program
ID : 2017ZX09304015
Pays : International
Organisme : CAMS Innovation Fund for Medical Sciences (CIFMS)
ID : 2016-I2M-1-001
Pays : International
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