Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception.
affect face matching
cingulate cortex
glutamate
regional specificity
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
25
10
2019
revised:
03
03
2020
accepted:
27
03
2020
pubmed:
3
4
2020
medline:
22
6
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
The cingulate cortex is involved in emotion recognition/perception and regulation. Rostral and caudal subregions belong to different brain networks with distinct roles in affective perception. Despite recent accounts of the relevance of cingulate cortex glutamate (Glu) on blood-oxygen-level-dependent (BOLD) responses, the specificity of the subregional Glu levels during emotional tasks remains unclear. Seventy-two healthy participants (age = 27.33 ± 6.67, 32 women) performed an affective face-matching task and underwent magnetic resonance spectroscopy (MRS) at 7 Tesla. Correlations between the BOLD response during emotion perception and Glu concentration in the pregenual anterior cingulate cortex (pgACC) and anterior midcingulate cortex (aMCC) were compared on a whole-brain level. Post hoc specificity of the association with an affect was assessed. Lower Glu in the pgACC correlated with stronger activation differences between negative and positive faces in the left inferior and superior frontal gyrus (L IFG and L SFG). In contrast, lower Glu in the aMCC correlated with BOLD contrasts in the posterior cingulate cortex (PCC). Furthermore, negative face detection was associated with prolonged response time (RT). Our results demonstrate a subregion-specific involvement of cingulate cortex Glu in interindividual differences during viewing of affective facial expressions. Glu levels in the pgACC were correlated with frontal area brain activations, whereas Glu in the salience network component aMCC modulated responses in the PCC-precuneus. We show that region-specific metabolite mapping enables specific activation of different BOLD signals in the brain underlying emotional perception.
Substances chimiques
Glutamic Acid
3KX376GY7L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3047-3060Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR2107 DA1151/5-1
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR2107 DA1151/5-2
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 779, 2013-2016
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 779/A06
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB-TRR58, Projects C09
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB-TRR58, Projects Z02
Organisme : Deutsche Forschungsgemeinschaft
ID : Wa2673/4-1
Organisme : Centre for Behavioral and Brain Science Magdeburg
ID : CBBS NN05
Organisme : Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg
ID : Dan3/012/17
Organisme : Leibniz-Gemeinschaft
Informations de copyright
© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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