Cytoprotective effects of antioxidant supplementation on mesenchymal stem cell therapy.
anoikis
apoptosis
autophagy
differentiation
nano antioxidant
oxidative stress
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
17
01
2020
accepted:
15
02
2020
pubmed:
3
4
2020
medline:
5
3
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
Mesenchymal stem cells (MSCs) are earmarked as perfect candidates for cell therapy and tissue engineering due to their capacity to differentiate into different cell types. However, their potential for application in regenerative medicine declines when the levels of the reactive oxygen and nitrogen species (RONS) increase from the physiological levels, a phenomenon which is at least inevitable in ex vivo cultures and air-exposed damaged tissues. Increased levels of RONS can alter the patterns of osteogenic and adipogenic differentiation and inhibit proliferation, as well. Besides, oxidative stress enhances senescence and cell death, thus lowering the success rates of the MSC engraftment. Hence, in this review, we have selected some representatives of antioxidants and newly emerged nano antioxidants in three main categories, including chemical compounds, biometabolites, and protein precursors/proteins, which are proved to be effective in the treatment of MSCs. We will focus on how antioxidants can be applied to optimize the clinical usage of the MSCs and their associated signaling pathways. We have also reviewed several paralleled properties of some antioxidants and nano antioxidants which can be simultaneously used in real-time imaging, scaffolding techniques, and other applications in addition to their primary antioxidative function.
Substances chimiques
Antioxidants
0
Protective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6462-6495Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
A Randomized trial of vitamin D supplementation with or without vitamin A in stem cell transplantation. https://ClinicalTrials.gov/show/NCT03202849
Aglan, H. A., Mabrouk, M., Aly, R. M., Beherei, H. H., & Ahmed, H. H. (2018). Harnessing the antioxidant property of cerium andyttrium oxide nanoparticles to enhance mesenchymal stem cell proliferation. Asian Journal of Pharmaceutical and Clinical Research, 11(9), 436-442.
Agrahari, G., Sah, S. K., & Kim, T.-Y. (2018). Superoxide dismutase 3 protects mesenchymal stem cells through enhanced autophagy and regulation of FoxO3a trafficking. BMB Reports, 51(7), 344-349.
Ahmed, H. H., Aglan, H. A., Mabrouk, M., Abd-Rabou, A. A., & Beherei, H. H. (2019). Enhanced mesenchymal stem cell proliferation through complexation of selenium/titanium nanocomposites. Journal of Materials Science, 30(2), 24.
Aliakbari, F., Sedighi Gilani, M. A., Yazdekhasti, H., Koruji, M., Asgari, H. R., Baazm, M., … Abbasi, M. (2017). Effects of antioxidants, catalase and α-tocopherol on cell viability and oxidative stress variables in frozen-thawed mice spermatogonial stem cells. Artificial Cells, Nanomedicine, and Biotechnology, 45(1), 63-68.
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007). Bioavailability of curcumin: Problems and promises. Molecular Pharmaceutics, 4(6), 807-818.
Anderson, S. A., Lee, K. K., & Frank, J. A. (2006). Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging. Investigative Radiology, 41(3), 332-338.
Ando, S., Funato, M., Ohuchi, K., Kameyama, T., Inagaki, S., Seki, J., … Kaneko, H. (2017). Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells-derived disease model. European Journal of Pharmacology, 814, 161-168.
Andrabi, S. S., Yang, J., Gao, Y., Kuang, Y., & Labhasetwar, V. (2020). Nanoparticles with antioxidant enzymes protect injured spinal cord from neuronal cell apoptosis by attenuating mitochondrial dysfunction. Journal of Controlled Release, 317, 300-311.
Ao, X. X., & Huang, H. (2017). Curcumin protects mesenchymal stem cells against oxidative stress-induced apoptosis via A Arsenic Trioxide With Ascorbic Acid kt/mTOR/p70S6K pathway. International Journal of Clinical and Experimental Pathology, 10(6), 6655-6664.
Arain, A., & Matthiesen, C. (2019). Vitamin D deficiency and graft-versus-host disease in hematopoietic stem cell transplant population. Hematology/Oncology and Stem Cell Therapy, 12(3), 133-139. https://doi.org/10.1016/j.hemonc.2018.08.001
Arsenic trioxide with ascorbic acid and melphalan for myeloma patients. https://ClinicalTrials.gov/show/NCT00661544
Asimakopoulou, A., Weiskirchen, S., & Weiskirchen, R. (2016). Lipocalin 2 (LCN2) expression in hepatic malfunction and therapy. Frontiers in Physiology, 7, 430.
Atashi, F., Modarressi, A., & Pepper, M. S. (2015). The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: A review. Stem Cells and Development, 24(10), 1150-1163.
Attari, F., Zahmatkesh, M., Aligholi, H., Mehr, S. E., Sharifzadeh, M., Gorji, A., … Hassanzadeh, G. (2015). Curcumin as a double-edged sword for stem cells: Dose, time and cell type-specific responses to curcumin. DARU Journal of Pharmaceutical Sciences, 23(1), 33.
Autologous hematopoietic stem cell transplantation in ischemic stroke. https://ClinicalTrials.gov/show/NCT01518231
Bahmani, B., Roudkenar, M. H., Halabian, R., Jahanian-Najafabadi, A., Amiri, F., & Jalili, M. A. (2014). Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress. Cell Stress and Chaperones, 19(5), 685-693.
Barclay, L. R. C., & Vinqvist, M. R. (2000). Do spin traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes. Free Radical Biology and Medicine, 28(7), 1079-1090.
Barry, F. P., & Murphy, J. M. (2004). Mesenchymal stem cells: Clinical applications and biological characterization. The International Journal of Biochemistry and Cell Biology, 36(4), 568-584.
Bell, M. R., Engleka, M. J., Malik, A., & Strickler, J. E. (2013). To fuse or not to fuse: What is your purpose? Protein Science, 22(11), 1466-1477.
Betteridge, D. J. (2000). What is oxidative stress? Metabolism: Clinical and Experimental, 49(2), 3-8.
Bhatti, F., Mehmood, A., Latief, N., Zahra, S., Cho, H., Khan, S., & Riazuddin, S. (2017). Vitamin E protects rat mesenchymal stem cells against hydrogen peroxide-induced oxidative stress in vitro and improves their therapeutic potential in surgically-induced rat model of osteoarthritis. Osteoarthritis and Cartilage, 25(2), 321-331.
Bhatti, F. U. R., Kim, S. J., Yi, A. K., Hasty, K. A., & Cho, H. (2018). Cytoprotective role of vitamin E in porcine adipose-tissue-derived mesenchymal stem cells against hydrogen-peroxide-induced oxidative stress. Cell and Tissue Research, 374(1), 111-120. https://doi.org/10.1007/s00441-018-2857-3
Boregowda, S. V., Booker, C. N., & Phinney, D. G. (2018). Mesenchymal stem cells: The moniker fits the science. Stem Cells, 36(1), 7-10.
Brandl, A., Meyer, M., Bechmann, V., Nerlich, M., & Angele, P. (2011). Oxidative stress induces senescence in human mesenchymal stem cells. Experimental Cell Research, 317(11), 1541-1547.
Buhrmann, C., Mobasheri, A., Matis, U., & Shakibaei, M. (2010). Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Research and Therapy, 12(4), R127.
Carr, W. J., Oberley-Deegan, R. E., Zhang, Y., Oberley, C. C., Oberley, L. W., & Dunnwald, M. (2011). Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics. Histochemistry and Cell Biology, 135(3), 293-304.
Carvalho, D. D. M., Takeuchi, K. P., Geraldine, R. M., Moura, C. J. d, & Torres, M. C. L. (2015). Production, solubility and antioxidant activity of curcumin nanosuspension. Food Science and Technology, 35(1), 115-119.
Chacko, S. M., Ahmed, S., Selvendiran, K., Kuppusamy, M. L., Khan, M., & Kuppusamy, P. (2010). Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. American Journal of Physiology-Cell Physiology, 299(6), C1562-C1570.
Chang, W., Song, B.-W., Moon, J.-Y., Cha, M.-J., Ham, O., Lee, S.-Y., … Hwang, K. (2013). Anti-death strategies against oxidative stress in grafted mesenchymal stem cells. Histology and Histopathology, 28(12), 1529-1536.
Chang, Y.-C., Chang, W.-C., Hung, K.-H., Yang, D.-M., Cheng, Y.-H., Liao, Y.-W., … Lin, T.-C. (2014). The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: Identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Frontiers in Aging Neuroscience, 6, 191.
Chant, A., Kraemer-Pecore, C. M., Watkin, R., & Kneale, G. G. (2005). Attachment of a histidine tag to the minimal zinc finger protein of the Aspergillus nidulans gene regulatory protein AreA causes a conformational change at the DNA-binding site. Protein Expression and Purification, 39(2), 152-159.
Chen, C. T., Shih, Y. R. V., Kuo, T. K., Lee, O. K., & Wei, Y. H. (2008). Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells, 26(4), 960-968.
Chen, R., Lai, U. H., Zhu, L., Singh, A., Ahmed, M., & Forsyth, N. R. (2018). Reactive oxygen species formation in the brain at different oxygen levels: The role of hypoxia inducible factors. Frontiers in Cell and Developmental Biology, 6, 132.
Cho, J., D'Antuono, M., Glicksman, M., Wang, J., & Jonklaas, J. (2018). A review of clinical trials: Mesenchymal stem cell transplant therapy in type 1 and type 2 diabetes mellitus. American Journal of Stem Cells, 7(4), 82.
Cho, Y. M., Kwon, S., Pak, Y. K., Seol, H. W., Choi, Y. M., Park, D. J., … Lee, H. K. (2006). Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells. Biochemical and Biophysical Research Communications, 348(4), 1472-1478.
Choi, K.-M., Seo, Y.-K., Yoon, H.-H., Song, K.-Y., Kwon, S.-Y., Lee, H.-S., & Park, J.-K. (2008). Effect of ascorbic acid on bone marrow-derived mesenchymal stem cell proliferation and differentiation. Journal of Bioscience and Bioengineering, 105(6), 586-594.
Choi, M. R., Kim, H. Y., Park, J.-Y., Lee, T. Y., Baik, C. S., Chai, Y. G., … Kim, K. S. (2010). Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis. Neuroscience Letters, 472(2), 94-98.
Choi, Y. J., Lee, C. M., Lee, J. H., Park, S. H., & Nam, M. J. (2019). Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells. Environmental Toxicology, 34(11), 1236-1245.
Chu, D. I., Lim, R., Heydrick, S., Gainsbury, M. L., Abdou, R., D'Addese, L., … Becker, J. M. (2011). N-acetyl-l-cysteine decreases intra-abdominal adhesion formation through the upregulation of peritoneal fibrinolytic activity and antioxidant defenses. Surgery, 149(6), 801-812.
Chu, S.-C., Chen, P.-N., Yu, C.-H., Hsieh, Y.-S., & Kuo, D.-Y. (2019). Role of hypoxia-inducible factor-1α in regulating oxidative stress and hypothalamic neuropeptides-mediated appetite control. Brain Research, 1721, 146329.
Coluzzi, E., Colamartino, M., Cozzi, R., Leone, S., Meneghini, C., O'Callaghan, N., & Sgura, A. (2014). Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells. PLOS One, 9(10):e110963.
Cremers, N., Lundvig, D., van Dalen, S., Schelbergen, R., van Lent, P., Szarek, W., … Wagener, F. (2014). Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells. International Journal of Molecular Sciences, 15(10), 17974-17999.
Cruz, M. P. (2018). Edaravone (Radicava): A novel neuroprotective agent for the treatment of amyotrophic lateral sclerosis. Pharmacy and Therapeutics, 43(1), 25.
Dehouck, M.-P., Cecchelli, R., Green, A. R., Renftel, M., & Lundquist, S. (2002). In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions. Brain Research, 955(1-2), 229-235.
DeLuca, H. F. (2004). Overview of general physiologic features and functions of vitamin D. The American Journal of Clinical Nutrition, 80(6), 1689S-1696S.
Dennis, J. E., Konstantakos, E. K., Arm, D., & Caplan, A. I. (1998). In vivo osteogenesis assay: A rapid method for quantitative analysis. Biomaterials, 19(15), 1323-1328.
Denu, R. A., & Hematti, P. (2016). Effects of oxidative stress on mesenchymal stem cell biology. Oxidative Medicine and Cellular Longevity, 2016, 1-9.
Dhoke, N. R., Geesala, R., & Das, A. (2018). Low oxidative stress-mediated proliferation via JNK-FOXO3a-catalase signaling in transplanted adult stem cells promotes wound tissue regeneration. Antioxidants and Redox Signaling, 28(11), 1047-1065.
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., … Horwitz, E. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy, 8(4), 315-317.
Dong, Y., Yang, J., Ye, W., Wang, Y., Ye, C., Weng, D., … Lei, Y. (2015). Isolation of endogenously assembled RNA-Protein complexes using affinity purification based on streptavidin aptamer S1. International Journal of Molecular Sciences, 16(9), 22456-22472. https://doi.org/10.3390/ijms160922456
Dröse, S., & Brandt, U. (2012). Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. In B. Kadenbach (Ed.), Mitochondrial oxidative phosphorylation (pp. 145-169). New York: Springer.
Ebert, R., Ulmer, M., Zeck, S., Meissner-Weigl, J., Schneider, D., Stopper, H., … Jakob, F. (2006). Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells, 24(5), 1226-1235.
Effect of NAC on the hematopoietic reconstitution after haploidentical hematopoietic stem cell transplantation. https://ClinicalTrials.gov/show/NCT03236220
Effect of vitamin C in autologous stem cell transplantations
Elmore, S. (2007). Apoptosis: A review of programmed cell death. Toxicologic Pathology, 35(4), 495-516.
Evaluate the efficacy of selenium for the prevention of chemotherapy-induced mucositis during autologous stem cell transplantation. https://ClinicalTrials.gov/show/NCT04080622
Ezquer, F. E., Ezquer, M. E., Vicencio, J. M., & Calligaris, S. D. (2017). Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: Increasing transplanted cell resistance and increasing tissue receptivity. Cell Adhesion and Migration, 11(1), 110-119.
Fan, G., Wen, L., Li, M., Li, C., Luo, B., Wang, F., … Liu, L. (2011). Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix. BMC Cell Biology, 12(1), 30.
Fang, J., Zhao, X., Li, S., Xing, X., Wang, H., Lazarovici, P., & Zheng, W. (2019). Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90(rsk)-CREB pathway. Stem Cell Research and Therapy, 10(1), 312. https://doi.org/10.1186/s13287-019-1419-2
Fechter, L. D., Liu, Y., & Pearce, T. A. (1997). Cochlear protection from carbon monoxide exposure by free radical blockers in the guinea pig. Toxicology and Applied Pharmacology, 142(1), 47-55.
Flora, G., Gupta, D., & Tiwari, A. (2013). Nanocurcumin: A promising therapeutic advancement over native curcumin. Critical Reviews, 30(4), 331-368.
Floyd, R. A., Kopke, R. D., Choi, C.-H., Foster, S. B., Doblas, S., & Towner, R. A. (2008). Nitrones as therapeutics. Free Radical Biology and Medicine, 45(10), 1361-1374.
Forostyak, S., & Sykova, E. (2017). Neuroprotective potential of cell-based therapies in ALS: From bench to bedside. Frontiers in Neuroscience, 11, 591.
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018). Reactive oxygen species in metabolic and inflammatory signaling. Circulation Research, 122(6), 877-902.
Friedenstein, A., Heersche, J., & Kanis, J. (1990). Bone and mineral research. Amsterdam: Elsevier.
Fujisawa, K., Hara, K., Takami, T., Okada, S., Matsumoto, T., Yamamoto, N., & Sakaida, I. (2018). Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells. Stem Cell Research and Therapy, 9(1), 93.
Fukami, G., Hashimoto, K., Koike, K., Okamura, N., Shimizu, E., & Iyo, M. (2004). Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine. Brain Research, 1016(1), 90-95.
Gao, B., Gao, W., Wu, Z., Zhou, T., Qiu, X., Wang, X., … Qiu, J. (2018). Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells. Stem Cell Research and Therapy, 9(1), 162.
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., … Perrett, S. (2007). Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature Nanotechnology, 2(9), 577-583.
Gao, Y., Wake, H., Morioka, Y., Liu, K., Teshigawara, K., Shibuya, M., … Nishibori, M. (2017). Phagocytosis of advanced glycation end products (AGEs) in macrophages induces cell apoptosis. Oxidative Medicine and Cellular Longevity, 2017.
Garg, S., & Garg, A. (2018). Encapsulation of curcumin in silver nanoparticle for enhancement of anticancer drug delivery. International Journal of Pharmaceutical Sciences and Research, 9, 1160-1166.
Gendelman, M., Halligan, N., Komorowski, R., Logan, B., Murphy, W. J., Blazar, B. R., … Drobyski, W. R. (2005). Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration. Blood, 105(1), 428-431.
Ghorbani, M., Derakhshankhah, H., Jafari, S., Salatin, S., Dehghanian, M., Falahati, M., & Ansari, A. (2019). Nanozyme antioxidants as emerging alternatives for natural antioxidants: Achievements and challenges in perspective. Nano Today, 29, 100775.
Glick, D., Barth, S., & Macleod, K. F. (2010). Autophagy: Cellular and molecular mechanisms. The Journal of Pathology, 221(1), 3-12.
Godoy-Parejo, C., Deng, C., Zhang, Y., Liu, W., & Chen, G. (2019). Roles of vitamins in stem cells. Cellular and Molecular Life Sciences, https://doi.org/10.1007/s00018-019-03352-6
Grebowski, J., Kazmierska, P., & Krokosz, A. (2013). Fullerenols as a new therapeutic approach in nanomedicine. BioMed Research International, 2013, 1-9.
Gregan, J., Riedel, C. G., Petronczki, M., Cipak, L., Rumpf, C., Poser, I., … Nasmyth, K. (2007). Tandem affinity purification of functional TAP-tagged proteins from human cells. Nature Protocols, 2(5), 1145-1151.
Gregory, D. A., Kumar, P., Jimenez-Franco, A., Zhang, Y., Zhang, Y., Ebbens, S. J., & Zhao, X. (2019). Reactive inkjet printing and propulsion analysis of silk-based self-propelled micro-stirrers. Journal of Visualized Experiments, 146, e59030.
Grove, J. E., Bruscia, E., & Krause, D. S. (2004). Plasticity of bone marrow-derived stem cells. Stem Cells, 22(4), 487-500.
Gu, Q., Cai, Y., Huang, C., Shi, Q., & Yang, H. (2012). Curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation. Pharmacognosy Magazine, 8(31), 202.
Gulati, K., Rai, N., & Ray, A. (2017). Effects of stress on reproductive and developmental biology. In R. C. Gupta (Ed.), Reproductive and Developmental Toxicology (2nd Ed., pp. 1063-1075). Elsevier.
Gupta, A., Das, S., Neal, C. J., & Seal, S. (2016). Controlling the surface chemistry of cerium oxide nanoparticles for biological applications. Journal of Materials Chemistry B, 4(19), 3195-3202.
Halabian, R., Tehrani, H. A., Jahanian-Najafabadi, A., & Roudkenar, M. H. (2013). Lipocalin-2-mediated upregulation of various antioxidants and growth factors protects bone marrow-derived mesenchymal stem cells against unfavorable microenvironments. Cell Stress and Chaperones, 18(6), 785-800.
Hämäläinen, R. H., Ahlqvist, K. J., Ellonen, P., Lepistö, M., Logan, A., Otonkoski, T., … Suomalainen, A. (2015). mtDNA mutagenesis disrupts pluripotent stem cell function by altering redox signaling. Cell Reports, 11(10), 1614-1624.
Hao, T., Zhou, J., Lü, S., Yang, B., Wang, Y., Fang, W., … Wang, C. (2016). Fullerene mediates proliferation and cardiomyogenic differentiation of adipose-derived stem cells via modulation of MAPK pathway and cardiac protein expression. International Journal of Nanomedicine, 11, 269.
Harbo, M., Koelvraa, S., Serakinci, N., & Bendix, L. (2012). Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress. DNA Repair, 11(9), 774-779.
Hasan, M., Belhaj, N., Benachour, H., Barberi-Heyob, M., Kahn, C., Jabbari, E., … Arab-Tehrany, E. (2014). Liposome encapsulation of curcumin: Physico-chemical characterizations and effects on MCF7 cancer cell proliferation. International Journal of Pharmaceutics, 461(1-2), 519-528.
Hawkins, C. L. (2004). EPR spin trapping of protein radicals. Free Radical Biology and Medicine, 36(9), 1072-1086.
Higashi, Y., Jitsuiki, D., Chayama, K., & Yoshizumi, M. (2006). Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Patents on Cardiovascular Drug Discovery, 1(1), 85-93.
Hiyama, E., & Hiyama, K. (2007). Telomere and telomerase in stem cells. British Journal of Cancer, 96(7), 1020-1024.
Holick, M. F. (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American Journal of Clinical Nutrition, 80(6), 1678S-1688S.
Holick, M. F. (2011). Vitamin D: A d-lightful solution for health. Journal of Investigative Medicine, 59(6), 872-880.
Hosseini, S., Chamani, J., Rahimi, H., Azmoodeh, N., Ghasemi, F., & Abadi, P. H. (2018). An in vitro study on curcumin delivery by nano-micelles for esophageal squamous cell carcinoma (KYSE-30). Reports of Biochemistry and Molecular Biology, 6(2), 137-143.
Hosseinzadeh Anvar, L., Hosseini-Asl, S., Mohammadzadeh-Vardin, M., & Sagha, M. (2017). The telomerase activity of selenium-induced human umbilical cord mesenchymal stem cells is associated with different levels of c-Myc and p53 expression. DNA and Cell Biology, 36(1), 34-41.
Hu, C., Zhao, L., Wu, D., & Li, L. (2019). Modulating autophagy in mesenchymal stem cells effectively protects against hypoxia-or ischemia-induced injury. Stem Cell Research and Therapy, 10(1), 120.
Hu, Y., Cheng, H., Zhao, X., Wu, J., Muhammad, F., Lin, S., … Deng, Y. (2017). Surface-enhanced Raman scattering active gold nanoparticles with enzyme-mimicking activities for measuring glucose and lactate in living tissues. ACS Nano, 11(6), 5558-5566.
Huang, D.-M., Hsiao, J.-K., Chen, Y.-C., Chien, L.-Y., Yao, M., Chen, Y.-K., … Cheng, H.-Y. (2009). The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles. Biomaterials, 30(22), 3645-3651.
Huang, Y., Ren, J., & Qu, X. (2019). Nanozymes: Classification, catalytic mechanisms, activity regulation, and applications. Chemical Reviews, 119(6), 4357-4412.
Hwang, W.-S., Park, S.-H., Kim, H.-S., Kang, H.-J., Kim, M.-J., Oh, S.-J., … Lee, J.-Y. (2007). Ascorbic acid extends replicative life span of human embryonic fibroblast by reducing DNA and mitochondrial damages. Nutrition Research and Practice, 1(2), 105-112.
Iamsawat, S., Daenthanasanmak, A., & Yu, X.-Z. (2018). Vitamin C stabilizes CD8iTregs and enhances their therapeutic potential in controlling GvHD and leukemia relapse. American Society of Hematology, 132, 4532.
Im, K.-I., Kim, N., Lim, J.-Y., Nam, Y.-S., Lee, E.-S., Kim, E.-J., … Cho, S.-G. (2015). The free radical scavenger NecroX-7 attenuates acute graft-versus-host disease via reciprocal regulation of Th1/regulatory T cells and inhibition of HMGB1 release. The Journal of Immunology, 194(11), 5223-5232.
Injac, R., Prijatelj, M., & Strukelj, B. (2013). Fullerenol nanoparticles: Toxicity and antioxidant activity. In D. Armstrong & D. J. Bharali (Eds.), Oxidative stress and nanotechnology (pp. 75-100). Totowa, NJ: Springer.
Inoue, M., Sato, E. F., Nishikawa, M., Park, A.-M., Kira, Y., Imada, I., & Utsumi, K. (2003). Mitochondrial generation of reactive oxygen species and its role in aerobic life. Current Medicinal Chemistry, 10(23), 2495-2505.
Ishihara, T., Nara, S., & Mizushima, T. (2014). Interactions of lecithinized superoxide dismutase with serum proteins and cells. Journal of Pharmaceutical Sciences, 103(7), 1987-1994.
Islam, A., Rebello, L., & Chepyala, S. (2019). Review on nanoformulations of curcumin (Curcuma longa Linn.): Special emphasis on Nanocurcumin®. International Journal of Nature and Life Science, 3(1), 1-12.
Ito, K., & Suda, T. (2014). Metabolic requirements for the maintenance of self-renewing stem cells. Nature Reviews Molecular Cell Biology, 15(4), 243-256.
Izadpanah, R., Trygg, C., Patel, B., Kriedt, C., Dufour, J., Gimble, J. M., & Bunnell, B. A. (2006). Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. Journal of Cellular Biochemistry, 99(5), 1285-1297.
Ji, A.-R., Ku, S.-Y., Cho, M. S., Kim, Y. Y., Kim, Y. J., Oh, S. K., … Choi, Y. M. (2010). Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage. Experimental and Molecular Medicine, 42(3), 175.
Ji, H., Liu, Y., Zhao, X., & Zhang, M. (2011). N-acetyl-L-cysteine enhances the osteogenic differentiation and inhibits the adipogenic differentiation through up regulation of Wnt 5a and down regulation of PPARG in bone marrow stromal cells. Biomedicine and Pharmacotherapy, 65(5), 369-374.
Jiang, B., Fang, L., Wu, K., Yan, X., & Fan, K. (2020). Ferritins as natural and artificial nanozymes for theranostics. Theranostics, 10(2), 687-706.
Johnson, A. A., Naaldijk, Y., Hohaus, C., & Meisel, H. J. (2017). Protective effects of alpha phenyl-tert-butyl nitrone and ascorbic acid in human adipose derived mesenchymal stem cells from differently aged donors. Aging, 9(2), 340-352.
Kaludercic, N., & Giorgio, V. (2016). The dual function of reactive oxygen/nitrogen species in bioenergetics and cell death: The role of ATP synthase. 1-17.
Kanda, Y., Hinata, T., Kang, S. W., & Watanabe, Y. (2011). Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells. Life Sciences, 89(7-8), 250-258.
Karlson, P., Dixon, H., Liebecq, C., Loening, K., Moss, G., Reedijk, J., … Vliegenthart, J. (1982). IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN): Nomenclature of vitamin D--recommendations 1981. European Journal of Biochemistry.
Karussis, D., Karageorgiou, C., Vaknin-Dembinsky, A., Gowda-Kurkalli, B., Gomori, J. M., Kassis, I., … Abramsky, O. (2010). Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Archives of Neurology, 67(10), 1187-1194.
Kazmi, A., Kazmi, A., Muhammad, W., & Azhar, M. (2019). Mesenchymal stem cells transplantation reduces diabetic nephropathy. Progress in Stem Cell, 6(1), 260-268.
Kernan, N. A., Bartsch, G., Ash, R. C., Beatty, P. G., Champlin, R., Filipovich, A., … McCullough, J. (1993). Analysis of 462 transplantations from unrelated donors facilitated by the national marrow donor program. New England Journal of Medicine, 328(9), 593-602.
Kikuchi, K., Setoyama, K., Kawahara, K.-I., Nagasato, T., Terashi, T., Ueda, K., … Sameshima, H. (2017). Edaravone, a synthetic free radical scavenger, enhances alteplase-mediated thrombolysis. Oxidative Medicine and Cellular Longevity, 2017, 1-14.
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015). The role of oxidative stress in neurodegenerative diseases. Experimental Neurobiology, 24(4), 325-340.
Kim, J. H., Lee, M. R., Jee, M., & Kang, S. (2008). IFATS collection: Selenium induces improvement of stem cell behaviors in human adipose-tissue stromal cells via SAPK/JNK and stemness acting signals. Stem Cells, 26(10), 2724-2734.
Kim, J. Y., Lee, J.-S., Han, Y.-S., Lee, J. H., Bae, I., Yoon, Y. M., … Lee, S. H. (2015). Pretreatment with lycopene attenuates oxidative stress-induced apoptosis in human mesenchymal stem cells. Biomolecules and Therapeutics, 23(6), 517-524. https://doi.org/10.4062/biomolther.2015.085
Kim, W.-S., Park, B.-S., & Sung, J.-H. (2009). The wound-healing and antioxidant effects of adipose-derived stem cells. Expert Opinion on Biological Therapy, 9(7), 879-887.
Knežević, N. Ž., Milenković, S., Jović, D., Lazarevic, S., Mrdjanović, J., & Djordjevic, A. (2015). Fullerenol-capped porous silica nanoparticles for pH-responsive drug delivery. Advances in Materials Science and Engineering, 2015, 1-6.
Ko, E., Lee, K. Y., & Hwang, D. S. (2011). Human umbilical cord blood-derived mesenchymal stem cells undergo cellular senescence in response to oxidative stress. Stem Cells and Development, 21(11), 1877-1886.
Kornicka, K., Houston, J., & Marycz, K. (2018). Dysfunction of mesenchymal stem cells isolated from metabolic syndrome and type 2 diabetic patients as result of oxidative stress and autophagy may limit their potential therapeutic use. Stem Cell Reviews and Reports, 14(3), 337-345.
Kornienko, J. S., Smirnova, I., Pugovkina, N., Ivanova, J. S., Shilina, M., Grinchuk, T., … Nikolsky, N. (2019). High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells. Scientific Reports, 9, 1296.
Kothari, S., Thompson, A., Agarwal, A., & du Plessis, S. S. (2010). Free radicals: Their beneficial and detrimental effects on sperm function. Indian Journal of Experimental Biology, 48, 425-435.
Kovel, E. S., Sachkova, A. S., Vnukova, N. G., Churilov, G. N., Knyazeva, E. M., & Kudryasheva, N. S. (2019). Antioxidant activity and toxicity of fullerenols via bioluminescence signaling: Role of oxygen substituents. International Journal of Molecular Sciences, 20(9), 2324.
Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. (2014). Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response. Free Radical Biology and Medicine, 69, 308-317.
Kumar, S., Bawa, S., & Gupta, H. (2009). Biological activities of quinoline derivatives. Mini Reviews in Medicinal Chemistry, 9(14), 1648-1654.
Kunamneni, A., Ogaugwu, C., & Goli, D. (2018). Enzymes as therapeutic agents, Enzymes in Human and Animal Nutrition (pp. 301-312. Elsevier.
Labhasetwar, V., & Jaffer, H. H. (2015). Methods of treating spinal cord injury. Google Patents.
Le Blanc, K., Rasmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M., & Ringdén, O. (2004). Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. The Lancet, 363(9419), 1439-1441.
Lee, J. H., Han, Y. S., & Lee, S. H. (2017). Potentiation of biological effects of mesenchymal stem cells in ischemic conditions by melatonin via upregulation of cellular prion protein expression. Journal of Pineal Research, 62(2):e12385.
Lee, J. H., Jung, H. K., Han, Y. S., Yoon, Y. M., Yun, C. W., Sun, H. Y., … Lee, S. H. (2016). Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Molecular Medicine Reports, 14(4), 3777-3784.
Lee, S., Choi, E., Cha, M.-J., & Hwang, K.-C. (2015). Cell adhesion and long-term survival of transplanted mesenchymal stem cells: A prerequisite for cell therapy. Oxidative Medicine and Cellular Longevity, 2015, 1-9.
Li, C.-J., Sun, L.-Y., & Pang, C.-Y. (2015). Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Scientific Reports, 5, 9819.
Li, H.-S., Zhou, Y.-N., Li, L., Li, S.-F., Long, D., Chen, X.-L., … Li, Y.-P. (2019). HIF-1α protects against oxidative stress by directly targeting mitochondria. Redox Biology, 25, 101109.
Li, T. S., & Marbán, E. (2010). Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells, 28(7), 1178-1185.
Li, W., Li, N., Sui, B., & Yang, D. (2017). Anti-aging effect of fullerenol on skin aging through derived stem cells in a mouse model. Experimental and Therapeutic Medicine, 14(5), 5045-5050.
Li, W., Liu, Y., Wang, B., Luo, Y., Hu, N., Chen, D., … Xiong, Y. (2016). Protective effect of berberine against oxidative stress-induced apoptosis in rat bone marrow-derived mesenchymal stem cells. Experimental and Therapeutic Medicine, 12(6), 4041-4048. https://doi.org/10.3892/etm.2016.3866
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., & Bao, J. (2017). Senescence of mesenchymal stem cells. International Journal of Molecular Medicine, 39(4), 775-782.
Li, Z.-H., Liao, W., Zhao, Q., Huan, T., Feng, P., Wei, X., … Shao, N.-S. (2014). Effect of Cbfa1 on osteogenic differentiation of mesenchymal stem cells under hypoxia condition. International Journal of Clinical and Experimental Medicine, 7(3), 540-548.
Liang, M., Fan, K., Pan, Y., Jiang, H., Wang, F., Yang, D., … Yang, L. (2013). Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent. Analytical Chemistry, 85(1), 308-312.
Liang, M., & Yan, X. (2019). Nanozymes: From new concepts, mechanisms, and standards to applications. Accounts of Chemical Research, 52(8), 2190-2200.
Lichty, J. J., Malecki, J. L., Agnew, H. D., Michelson-Horowitz, D. J., & Tan, S. (2005). Comparison of affinity tags for protein purification. Protein Expression and Purification, 41(1), 98-105.
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., … Bonaduce, D. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757-772.
Lin, T.-K., Hughes, G., Muratovska, A., Blaikie, F. H., Brookes, P. S., Darley-Usmar, V., … Murphy, M. P. (2002). Specific modification of mitochondrial protein thiols in response to oxidative stress: A proteomics approach. Journal of Biological Chemistry, 277(19), 17048-17056.
Liu, G.-Y, Jiang, X.-X, Zhu, X., He, W.-Y, Kuang, Y.-L, Ren, K., … Gou, X. (2015). ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro. Acta Pharmacologica Sinica, 36(12), 1473-1479.
Liu, H., Yang, X., Zhang, Y., Dighe, A., Li, X., & Cui, Q. (2012). Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. Journal of Orthopaedic Research, 30(7), 1051-1057.
Liuzzi, F., Fanelli, C., Ciriolo, M. R., Cerella, C., D'alessio, M., Denicola, M., … Ghibelli, L. (2003). Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. Annals of the New York Academy of Sciences, 1010(1), 441-445.
Mackay, A. M., Beck, S. C., Murphy, J. M., Barry, F. P., Chichester, C. O., & Pittenger, M. F. (1998). Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Engineering, 4(4), 415-428.
Maheshwari, R. K., Singh, A. K., Gaddipati, J., & Srimal, R. C. (2006). Multiple biological activities of curcumin: A short review. Life Sciences, 78(18), 2081-2087.
Malladi, P., Xu, Y., Yang, G. P., & Longaker, M. T. (2006). Functions of vitamin D, retinoic acid, and dexamethasone in mouse adipose-derived mesenchymal cells. Tissue Engineering, 12(7), 2031-2040.
Marin, E., Briceño, M. I., Torres, A., & Caballero-George, C. (2017). New curcumin-loaded chitosan nanocapsules: In vivo evaluation. Planta Medica, 83(10), 877-883.
Mayer, A., Sharma, S., Tolner, B., Minton, N., Purdy, D., Amlot, P., … Chester, K. (2004). Modifying an immunogenic epitope on a therapeutic protein: A step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT). British Journal of Cancer, 90(12), 2402-2410.
Mehta, S. K., & Gowder, S. J. T. (2015). Members of antioxidant machinery and their functions. Basic Principles and Clinical Significance of Oxidative Stress, 59-85.
Menon, S. G., Sarsour, E. H., Kalen, A. L., Venkataraman, S., Hitchler, M. J., Domann, F. E., … Goswami, P. C. (2007). Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: Regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer Research, 67(13), 6392-6399.
Miyata, T., Kurokawa, K., & De Strihou, C. V. Y. (2000). Relevance of oxidative and carbonyl stress to long-term uremic complications. Kidney International, 58, S120-S125.
Mogharbel, B. F., Francisco, J. C., Irioda, A. C., Dziedzic, D. S. M., Ferreira, P. E., de Souza, D., … Franco, C. R. C. (2018). Fluorescence properties of curcumin-loaded nanoparticles for cell tracking. International Journal of Nanomedicine, 13, 5823-5836.
Moosmann, B., & Behl, C. (2002). Antioxidants as treatment for neurodegenerative disorders. Expert Opinion on Investigational Drugs, 11(10), 1407-1435.
Mráček, T., Drahota, Z., & Houštěk, J. (2013). The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues. Biochimica et Biophysica Acta, 1827(3), 401-410.
Murahashi, S.-I., & Imada, Y. (2019). Synthesis and transformations of nitrones for organic synthesis. Chemical Reviews, 119(7), 4684-4716.
N-acetyl cysteine protects pulpal stem cells in endodontic revascularization. https://ClinicalTrials.gov/show/NCT03451435
Nakaizumi, A., Horie, T., Kida, T., Kurimoto, T., Sugiyama, T., Ikeda, T., & Oku, H. (2012). Nitric oxide potentiates TNF-α-induced neurotoxicity through suppression of NF-κB. Cellular and Molecular Neurobiology, 32(1), 95-106.
Nambiar, S., Osei, E., Fleck, A., Darko, J., Mutsaers, A. J., & Wettig, S. (2018). Synthesis of curcumin-functionalized gold nanoparticles and cytotoxicity studies in human prostate cancer cell line. Applied Nanoscience, 8(3), 347-357.
Narwal, S., Kumar, S., & Verma, P. K. (2017). Synthesis and therapeutic potential of quinoline derivatives. Research on Chemical Intermediates, 43(5), 2765-2798.
Nazem, S., Masoumi, M., Amirizadeh, N., Zolghadr, F., & Sadeghizadeh, M. (2017). Protective effect of encapsulated nanocurcumin-PEGOA against oxidative damage on human mesenchymal stem cells exposed to hydroquinone as a risk factor for leukemia. Multidisciplinary Cancer Investigation, 1(1), 3-10.
Nie, X., Tang, J., Liu, Y., Cai, R., Miao, Q., Zhao, Y., & Chen, C. (2017). Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling. Nanomedicine: Nanotechnology, Biology and Medicine, 13(6), 1879-1890.
Niki, E., & Abe, K. (2019). Vitamin E: Structure, properties and functions. In E. Niki (Ed.), Vitamin E: Chemistry and nutritional benefits. London: Royal Society of Chemistry.
Nimse, S. B., & Pal, D. (2015). Free radicals, natural antioxidants, and their reaction mechanisms. RSC Advances, 5(35), 27986-28006.
Noguchi, M., Yamawaki, I., Takahashi, S., Taguchi, Y., & Umeda, M. (2018). Effects of α-tocopherol on bone marrow mesenchymal cells derived from type II diabetes mellitus rats. Journal of Oral Science, 60(4), 579-587.
Oh, S. H., Ward, C. L., Atala, A., Yoo, J. J., & Harrison, B. S. (2009). Oxygen generating scaffolds for enhancing engineered tissue survival. Biomaterials, 30(5), 757-762.
Oral selenium therapy for the prevention of mucositis. https://ClinicalTrials.gov/show/NCT01432873
Otsu, K., Das, S., Houser, S. D., Quadri, S. K., Bhattacharya, S., & Bhattacharya, J. (2009). Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells. Blood, 113(18), 4197-4205.
Palová Jelínková, L., Grohová, A., Dáňová, K., & Spisek, R. (2019). Cell based therapy for type 1 diabetes: Should we take hyperglycemia into account? Frontiers in Immunology, 10, 79.
Park, J., Lee, J. H., Yoon, B. S., Jun, E. K., Lee, G., Kim, I. Y., & You, S. (2018). Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells. Stem Cell Research and Therapy, 9(1), 293.
Park, S.-H., Kim, J.-H., Nam, S.-W., Kim, B.-W., Kim, G.-Y., Kim, W.-J., & Choi, Y. H. (2014). Selenium improves stem cell potency by stimulating the proliferation and active migration of 3T3-L1 preadipocytes. International Journal of Oncology, 44(1), 336-342.
Pasha, Z., Wang, Y., Sheikh, R., Zhang, D., Zhao, T., & Ashraf, M. (2007). Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovascular Research, 77(1), 134-142.
Pelicano, H., Carney, D., & Huang, P. (2004). ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates, 7(2), 97-110.
Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2015). Free radicals: Properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry, 30(1), 11-26.
Pierre, J., Baret, P., & Serratrice, G. (2003). Hydroxyquinolines as iron chelators. Current Medicinal Chemistry, 10(12), 1077-1084.
Pirmoradi, S., Fathi, E., Farahzadi, R., Pilehvar-Soltanahmadi, Y., & Zarghami, N. (2018). Curcumin affects adipose tissue-derived mesenchymal stem cell aging through TERT gene expression. Drug Research, 68(04), 213-221.
Pogacean, F., Socaci, C., Pruneanu, S., Biris, A. R., Coros, M., Magerusan, L., … Borodi, G. (2015). Graphene based nanomaterials as chemical sensors for hydrogen peroxide-A comparison study of their intrinsic peroxidase catalytic behavior. Sensors and Actuators, B: Chemical, 213, 474-483.
Posa, F., Di Benedetto, A., Cavalcanti-Adam, E. A., Colaianni, G., Porro, C., Trotta, T., … Mori, G. (2018). Vitamin D promotes MSC osteogenic differentiation stimulating cell adhesion and αVβ3 expression. Stem Cells International, 2018, 1-9.
Posa, F., Di Benedetto, A., Colaianni, G., Cavalcanti-Adam, E. A., Brunetti, G., Porro, C., … Mori, G. (2016). Vitamin D effects on osteoblastic differentiation of mesenchymal stem cells from dental tissues. Stem Cells International, 2016, 1-9.
Potdar, P. D., & D'souza, S. B. (2010). Ascorbic acid induces in vitro proliferation of human subcutaneous adipose tissue derived mesenchymal stem cells with upregulation of embryonic stem cell pluripotency markers Oct4 and SOX 2. Human Cell, 23(4), 152-155.
Prachayasittikul, V., Prachayasittikul, S., Ruchirawat, S., & Prachayasittikul, V. (2013). 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications. Drug Design, Development and Therapy, 7, 1157.
Prockop, D. J., Brenner, M., Fibbe, W. E., Horwitz, E., Le Blanc, K., Phinney, D. G., … Keating, A. (2010). Defining the risks of mesenchymal stromal cell therapy. Cytotherapy, 12(5), 576-578.
Prolonged isolated thrombocytopenia after allo-SCT: N-acetyl-L-cysteine (NAC) versus supportive therapy. https://ClinicalTrials.gov/show/NCT03391856
Rameshraja, D., Srivastava, V. C., Kushwaha, J. P., & Mall, I. D. (2012). Quinoline adsorption onto granular activated carbon and bagasse fly ash. Chemical Engineering Journal, 181, 343-351.
Ranchon, I., Chen, S., Alvarez, K., & Anderson, R. E. (2001). Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage. Investigative Ophthalmology and Visual Science, 42(6), 1375-1379.
Rani, V., Deep, G., Singh, R. K., Palle, K., & Yadav, U. C. (2016). Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sciences, 148, 183-193.
Ranjbar, A., Gholami, L., Ghasemi, H., & Kheiripour, N. (2020). Effects of nano-curcumin and curcumin on the oxidant and antioxidant system of the liver mitochondria in aluminum phosphide-induced experimental toxicity. Nanomedicine Journal, 7(1), 58-64.
Reddy, M. K., Wu, L., Kou, W., Ghorpade, A., & Labhasetwar, V. (2008). Superoxide dismutase-loaded PLGA nanoparticles protect cultured human neurons under oxidative stress. Applied Biochemistry and Biotechnology, 151(2-3), 565-577.
Redondo, J., Sarkar, P., Kemp, K., Heesom, K. J., Wilkins, A., Scolding, N. J., & Rice, C. M. (2018). Dysregulation of mesenchymal stromal cell antioxidant responses in progressive multiple sclerosis. Stem Cells Translational Medicine, 7(10), 748-758.
Redondo, J., Sarkar, P., Kemp, K., Virgo, P. F., Pawade, J., Norton, A., … Wilkins, A. (2018). Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro. Multiple Sclerosis Journal, 24(7), 919-931.
Redza-Dutordoir, M., & Averill-Bates, D. A. (2016). Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica et Biophysica Acta, 1863(12), 2977-2992.
Rengel, R. G., Barišić, K., Pavelić, Ž., Grubišić, T. Ž., Čepelak, I., & Filipović-Grčić, J. (2002). High efficiency entrapment of superoxide dismutase into mucoadhesive chitosan-coated liposomes. European Journal of Pharmaceutical Sciences, 15(5), 441-448.
Ricq, E. L., Hooker, J. M., & Haggarty, S. J. (2016). Activity-dependent regulation of histone lysine demethylase KDM1A by a putative thiol/disulfide switch. Journal of Biological Chemistry, 291(47), 24756-24767.
Risk stratification-directed NAC for prevention of poor hematopoietic reconstitution. https://ClinicalTrials.gov/show/NCT03967665
Roberts, M., Bentley, M., & Harris, J. (2012). Chemistry for peptide and protein PEGylation. Advanced Drug Delivery Reviews, 64, 116-127.
Rodrigues, M., Turner, O., Stolz, D., Griffith, L. G., & Wells, A. (2012). Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplantation, 21(10), 2171-2187.
Ross, A. C., Manson, J. E., Abrams, S. A., Aloia, J. F., Brannon, P. M., Clinton, S. K., … Jones, G. (2011). The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: What clinicians need to know. The Journal of Clinical Endocrinology and Metabolism, 96(1), 53-58.
Roudkenar, M. H., Halabian, R., Bahmani, P., Roushandeh, A. M., Kuwahara, Y., & Fukumoto, M. (2011). Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on heme oxygenase-1. Free Radical Research, 45(7), 810-819.
Roudkenar, M. H., Halabian, R., Tehrani, H. A., Amiri, F., Jahanian-Najafabadi, A., Roushandeh, A. M., & Abbasi-Malati, Z. (2018). Lipocalin 2 enhances mesenchymal stem cell-based cell therapy in acute kidney injury rat model. Cytotechnology, 70(1), 103-117.
Roudkenar, M. H., Kuwahara, Y., Baba, T., Roushandeh, A. M., Ebishima, S., Abe, S., … Fukumoto, M. (2007). Oxidative stress induced lipocalin 2 gene expression: Addressing its expression under the harmful conditions. Journal of Radiation Research, 48(1), 39-44.
Sachkova, A., Kovel, E., Churilov, G., Guseynov, O., Bondar, A., Dubinina, I., & Kudryasheva, N. (2017). On mechanism of antioxidant effect of fullerenols. Biochemistry and Biophysics Reports, 9, 1-8.
Sagristá, M. L., GarcÍa, A. F., De Madariaga, M. A., & Mora, M. (2002). Antioxidant and pro-oxidant effect of the thiolic compounds N-acetyl-L-cysteine and glutathione against free radical-induced lipid peroxidation. Free Radical Research, 36(3), 329-340.
Salgado, P., Melin, V., Contreras, D., Moreno, Y., & Mansilla, H. D. (2013). Fenton reaction driven by iron ligands. Journal of the Chilean Chemical Society, 58(4), 2096-2101.
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., … Artandi, S. E. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature, 436(7053), 1048-1052.
Sart, S., Song, L., & Li, Y. (2015). Controlling redox status for stem cell survival, expansion, and differentiation. In N. Knoepffler (Ed.), Oxidative medicine and cellular longevity (2015, pp. 1-14). London: Routledge.
Sato, Y., Mera, H., Takahashi, D., Majima, T., Iwasaki, N., Wakitani, S., & Takagi, M. (2017). Synergistic effect of ascorbic acid and collagen addition on the increase in type 2 collagen accumulation in cartilage-like MSC sheet. Cytotechnology, 69(3), 405-416.
Saulite, L., Jekabsons, K., Klavins, M., Muceniece, R., & Riekstina, U. (2019). Effects of malvidin, cyanidin and delphinidin on human adipose mesenchymal stem cell differentiation into adipocytes, chondrocytes and osteocytes. Phytomedicine, 53, 86-95.
Schieber, M., & Chandel, N. S. (2014). ROS function in redox signaling and oxidative stress. Current Biology, 24(10), R453-R462.
Schipanski, D., Knoepffler, N., & Sorgner, S. L. (2016). Humanbiotechnology as social challenge: An interdisciplinary introduction to bioethics. London: Routledge.
Schumacker, P. T. (2015). Reactive oxygen species in cancer: A dance with the devil. Cancer Cell, 27(2), 156-157.
Sena, L. A., & Chandel, N. S. (2012). Physiological roles of mitochondrial reactive oxygen species. Molecular Cell, 48(2), 158-167.
Shaban, S., El-Husseny, M. W. A., Abushouk, A. I., Salem, A. M. A., Mamdouh, M., & Abdel-Daim, M. M. (2017). Effects of antioxidant supplements on the survival and differentiation of stem cells. Oxidative Medicine and Cellular Longevity, 2017, 1-16.
Sharifi, M., Faryabi, K., Talaei, A. J., Shekha, M. S., Ale-Ebrahim, M., Salihi, A., … Hasan, A. (2019). Antioxidant properties of gold nanozyme: A review. Journal of Molecular Liquids, 297, 112004.
Sharifi, S., Vahed, S. Z., Ahmadian, E., Dizaj, S. M., Abedi, A., Khatibi, S. M. H., & Samiei, M. (2019). Stem cell therapy: Curcumin does the trick. Phytotherapy Research, 33, 2927-2937.
Sharma, J., Hampton, J. M., Valiente, G. R., Wada, T., Steigelman, H., Young, M. C., … Jarjour, W. N. (2017). Therapeutic development of mesenchymal stem cells or their extracellular vesicles to inhibit autoimmune-mediated inflammatory processes in systemic lupus erythematosus. Frontiers in Immunology, 8, 526.
Shi, D., Li, X., Chen, H., Che, N., Zhou, S., Lu, Z., … Sun, L. (2014). High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus. Pathologie Biologie, 62(6), 382-390.
Shi, Y., Nan, C., Yan, Z., Liu, L., Zhou, J., Zhao, Z., & Li, D. (2018). Synaptic plasticity of human umbilical cord mesenchymal stem cell differentiating into neuron-like cells in vitro induced by Edaravone. Stem Cells International, 2018, 1-11. https://doi.org/10.1155/2018/5304279
Shimizu, E., Hashimoto, K., Komatsu, N., & Iyo, M. (2002). Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells. Neuropharmacology, 43(3), 434-443.
Shin, H. Y., Park, T. J., & Kim, M. I. (2015). Recent research trends and future prospects in nanozymes. Journal of Nanomaterials, 2015, 1-11.
Shokrollahzade, S., Sharifi, F., Vaseghi, A., Faridounnia, M., & Jahandideh, S. (2015). Protein cold adaptation: Role of physico-chemical parameters in adaptation of proteins to low temperatures. Journal of Theoretical Biology, 383, 130-137.
Shyh-Chang, N., Daley, G. Q., & Cantley, L. C. (2013). Stem cell metabolism in tissue development and aging. Development, 140(12), 2535-2547.
Singh, D., Nishal, V., Bhagwan, S., Saini, R. K., & Singh, I. (2018). Electroluminescent materials: Metal complexes of 8-hydroxyquinoline-A review. Materials and Design, 156, 215-228.
Singh, S. (2019). Nanomaterials exhibiting enzyme-like properties (Nanozymes): Current advances and future perspectives. Frontiers in Chemistry, 7, 46.
Singhal, A., Morris, V., Labhasetwar, V., & Ghorpade, A. (2013). Nanoparticle-mediated catalase delivery protects human neurons from oxidative stress. Cell Death and Disease, 4(11):e903.
Song, C.-G., Zhang, Y.-Z., Wu, H.-N., Cao, X.-L., Guo, C.-J., Li, Y.-Q., … Han, H. (2018). Stem cells: A promising candidate to treat neurological disorders. Neural Regeneration Research, 13(7), 1294.
Song, H., Cha, M. J., Song, B. W., Kim, I. K., Chang, W., Lim, S., … Chung, N. (2010). Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex. Stem Cells, 28(3), 555-563.
Song, N. G., Sun, J. J., Zhang, Y. L., Meng, L. H., Gao, S. H., Xue, J., & Sun, C. Y. (2016). Expression of serum inflammatory cytokines in rats with cerebral infarction undergoing bone marrow mesenchymal stem cell transplantation combined with edaravone. Chinese Journal of Tissue Engineering Research, 20(28), 4162-4168. https://doi.org/10.3969/j.issn.2095-4344.2016.28.009
Srisawat, C., Goldstein, I. J., & Engelke, D. R. (2001). Sephadex-binding RNA ligands: Rapid affinity purification of RNA from complex RNA mixtures. Nucleic Acids Research, 29(2):E4. https://doi.org/10.1093/nar/29.2.e4
Suh, J. H., Kanathezhath, B., Shenvi, S., Guo, H., Zhou, A., Tiwana, A., … Walters, M. C. (2014). Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD). PLOS One, 9(2):e88868.
Sun, L.-Y., Pang, C.-Y., Li, D.-K., Liao, C.-H., Huang, W.-C., Wu, C.-C., … Liu, H.-W. (2013). Antioxidants cause rapid expansion of human adipose-derived mesenchymal stem cells via CDK and CDK inhibitor regulation. Journal of Biomedical Science, 20(1), 53.
Suzuki, Y. J., Carini, M., & Butterfield, D. A. (2010). Protein carbonylation. Antioxidants and Redox Signaling, 12(3), 323-325.
Tabatabaie, T., Kotake, Y., Wallis, G., Jacob, J. M., & Floyd, R. A. (1997). Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus. FEBS Letters, 407(2), 148-152.
Tang, Y.-T, Sun, Y.-F, Li, X.-J, Jin, Z., Tong, H., Li, J.-J, & Zhang, Q. (2016). Effects of fullerol on the osteogenic differentiation of adipose-derived mesenchymal stem cells. Medical Journal of Chinese People's Liberation Army, 41(8), 624-628.
Tao, Y., Ju, E., Ren, J., & Qu, X. (2014). Polypyrrole nanoparticles as promising enzyme mimics for sensitive hydrogen peroxide detection. Chemical Communications, 50(23), 3030-3032.
Terrill, J. R., Radley-Crabb, H. G., Iwasaki, T., Lemckert, F. A., Arthur, P. G., & Grounds, M. D. (2013). Oxidative stress and pathology in muscular dystrophies: Focus on protein thiol oxidation and dysferlinopathies. The FEBS Journal, 280(17), 4149-4164.
Therapeutic use of intravenous vitamin C in allogeneic stem cell transplant recipients. https://ClinicalTrials.gov/show/NCT03613727
Tsai, T.-L., & Li, W.-J. (2017). Identification of bone marrow-derived soluble factors regulating human mesenchymal stem cells for bone regeneration. Stem Cell Reports, 8(2), 387-400.
Turrens, J. F. (2003). Mitochondrial formation of reactive oxygen species. The Journal of Physiology, 552(2), 335-344.
Tóth, A. E., Walter, F. R., Bocsik, A., Sántha, P., Veszelka, S., Nagy, L., … Dohgu, S. (2014). Edaravone protects against methylglyoxal-induced barrier damage in human brain endothelial cells. PLOS One, 9(7):e100152.
Udalamaththa, V. L., Jayasinghe, C. D., & Udagama, P. V. (2016). Potential role of herbal remedies in stem cell therapy: Proliferation and differentiation of human mesenchymal stromal cells. Stem Cell Research and Therapy, 7(1), 110.
Uma, P., Suresh, J., Selvaraj, R., Karthik, S., & Arun, A. (2015). Quinoline based polymeric drug for biological applications: Synthesis, characterization, antimicrobial, and drug releasing studies. Journal of Biomaterials Science, Polymer Edition, 26(2), 128-142. https://doi.org/10.1080/09205063.2014.985022
Valadbeygi, A., Naji, T., & Gholami, M. (2016). Supplementation freeze-thawed media with selenium protect adipose-derived mesenchymal stem cells from freeze-thawed induced injury. Cryobiology, 73(2), 135-139.
Valle-Prieto, A., & Conget, P. A. (2010). Human mesenchymal stem cells efficiently manage oxidative stress. Stem Cells and Development, 19(12), 1885-1893.
Varum, S., Rodrigues, A. S., Moura, M. B., Momcilovic, O., Easley, C. A., Ramalho-Santos, J., … Schatten, G. (2011). Energy metabolism in human pluripotent stem cells and their differentiated counterparts. Plos one, 6(6), e20914.
Veronese, F. M., Caliceti, P., Schiavon, O., & Sergi, M. (2002). Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation. Advanced Drug Delivery Reviews, 54(4), 587-606.
Vono, R., Jover Garcia, E., Spinetti, G., & Madeddu, P. (2018). Oxidative stress in mesenchymal stem cell senescence: Regulation by coding and noncoding RNAs. Antioxidants and Redox Signaling, 29(9), 864-879.
Wagner, W., Wein, F., Seckinger, A., Frankhauser, M., Wirkner, U., Krause, U., … Ansorge, W. (2005). Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Experimental Hematology, 33(11), 1402-1416.
Walther, F. J., Wade, A. B., Warburton, D., & Forman, H. J. (1991). Ontogeny of antioxidant enzymes in the fetal lamb lung. Experimental Lung Research, 17(1), 39-45.
Wang, F., Zhou, H., Du, Z., Chen, X., Zhu, F., Wang, Z., … Zhang, X. (2015). Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. European Journal of Pharmacology, 748, 157-165.
Wang, F. W., Wang, Z., Zhang, Y. M., Du, Z. X., Zhang, X. L., Liu, Q., … Hao, A. J. (2013). Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro. Journal of Cellular Biochemistry, 114(10), 2346-2355.
Wang, J., Ma, J., Gu, J. H., Wang, F. Y., Shang, X. S., Tao, H. R., & Wang, X. (2017). Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes. Molecular Medicine Reports, 16(2), 1837-1845.
Wang, Q., Wei, H., Zhang, Z., Wang, E., & Dong, S. (2018). Nanozyme: An emerging alternative to natural enzyme for biosensing and immunoassay. Trends in Analytical Chemistry, 105, 218-224.
Wang, T. T., Zeng, G. C., Li, X. C., & Zeng, H. P. (2010). In vitro studies on the antioxidant and protective effect of 2-substituted-8-hydroxyquinoline derivatives against H2O2-induced oxidative stress in BMSCs. Chemical biology & drug design, 75(2), 214-222.
Wang, X., Hu, Y., & Wei, H. (2016). Nanozymes in bionanotechnology: From sensing to therapeutics and beyond. Inorganic Chemistry Frontiers, 3(1), 41-60.
Wang, Y., Chen, G., Yan, J., Chen, X., He, F., Zhu, C., … Yu, J. (2018). Upregulation of SIRT1 by kartogenin enhances antioxidant functions and promotes osteogenesis in human mesenchymal stem cells. Oxidative Medicine and Cellular Longevity, 2018, 1-15.
Wang, Z., Li, H., Guo, R., Wang, Q., & Zhang, D. (2016). Antioxidants inhibit advanced glycosylation end-product-induced apoptosis by downregulation of miR-223 in human adipose tissue-derived stem cells. Scientific Reports, 6, 23021.
Watanabe, J., Yamada, M., Niibe, K., Zhang, M., Kondo, T., Ishibashi, M., & Egusa, H. (2018). Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress. Biomaterials, 185, 25-38.
Wei, F., Qu, C., Song, T., Ding, G., Fan, Z., Liu, D., … Wang, S. (2012). Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity. Journal of Cellular Physiology, 227(9), 3216-3224.
Wei, H., Li, Z., Hu, S., Chen, X., & Cong, X. (2010). Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. Journal of Cellular Biochemistry, 111(4), 967-978.
Wei, J. P., Zeng, H. P., Xu, D. F., & Liu, J. (2008). Synthesis, fluorescence properties and biological activity of 8-hydroxyquinoline conjugate bonded aromatic heterocyclic derivatives. Chinese Journal of Chemistry, 26(7), 1299-1304.
Widlansky, M. E., & Gutterman, D. D. (2011). Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxidants and Redox Signaling, 15(6), 1517-1530.
Wood, D. W. (2014). New trends and affinity tag designs for recombinant protein purification. Current Opinion in Structural Biology, 26, 54-61.
Wu, D., & Yotnda, P. (2011). Production and detection of reactive oxygen species (ROS) in cancers. Journal of Visualized Experiments, 57).
Wu, K. H., Mo, X. M., Han, Z. C., & Zhou, B. (2011). Stem cell engraftment and survival in the ischemic heart. The Annals of Thoracic Surgery, 92(5), 1917-1925.
Wu, S., Zhang, J., & Wu, P. (2019). Photo-modulated nanozymes for biosensing and biomedical applications. Analytical Methods, 11(40), 5081-5088.
Wu, Y.-P., Chen, W.-S., Teng, C., & Zhang, N. (2010). Stem cells for the treatment of neurodegenerative diseases. Molecules, 15(10), 6743-6758.
Xiong, L., Sun, J., Hirche, C., Yang, J., Yang, Y., Xia, Y., … Fu, X. (2012). In vitro N-acetyl-L-cysteine promotes proliferation and suppresses interleukin-8 expression in adipose-derived stem cells. Aesthetic Plastic Surgery, 36(5), 1260-1265.
Xu, H., Chen, W., Zhan, P., & Liu, X. (2015). 8-Hydroxyquinoline: A privileged structure with a broad-ranging pharmacological potential. MedChemComm, 6(1), 61-74.
Yaghooti, H., Mohammadtaghvaei, N., & Mahboobnia, K. (2019). Effects of palmitate and astaxanthin on cell viability and proinflammatory characteristics of mesenchymal stem cells. International Immunopharmacology, 68, 164-170.
Yagi, H., Tan, J., & Tuan, R. S. (2013). Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells. Journal of Cellular Biochemistry, 114(5), 1163-1173.
Yanada, S., Ochi, M., Kojima, K., Sharman, P., Yasunaga, Y., & Hiyama, E. (2006). Possibility of selection of chondrogenic progenitor cells by telomere length in FGF-2-expanded mesenchymal stromal cells. Cell Proliferation, 39(6), 575-584.
Yang, C.-Y., Tai, M.-F., Lin, C.-P., Lu, C.-W., Wang, J.-L., Hsiao, J.-K., & Liu, H.-M. (2011). Mechanism of cellular uptake and impact of ferucarbotran on macrophage physiology. PLOS One, 6(9):e25524.
Yang, M., Teng, S., Ma, C., Yu, Y., Wang, P., & Yi, C. (2018). Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling. Cytotechnology, 70(5), 1301-1313.
Yang, X., Li, C.-J., Wan, Y., Smith, P., Shang, G., & Cui, Q. (2014). Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells. International Journal of Nanomedicine, 9, 4023.
Yang, Z., He, C., He, J., Chu, J., Liu, H., & Deng, X. (2018). Curcumin-mediated bone marrow mesenchymal stem cell sheets create a favorable immune microenvironment for adult full-thickness cutaneous wound healing. Stem Cell Research and Therapy, 9(1), 21.
Yen, F.-L., Wu, T.-H., Tzeng, C.-W., Lin, L.-T., & Lin, C.-C. (2010). Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. Journal of Agricultural and Food Chemistry, 58(12), 7376-7382.
Yoboue, E. D., Sitia, R., & Simmen, T. (2018). Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages. Cell Death and Disease, 9(3), 1-14.
Yousefi, F., Arab, F. L., Jaafari, M. R., Rastin, M., Tabasi, N., Hatamipour, M., … Mahmoudi, M. (2019). Immunoregulatory, proliferative and anti-oxidant effects of nanocurcuminoids on adipose-derived mesenchymal stem cells. EXCLI Journal, 18, 405-421.
Zafarullah, M., Li, W., Sylvester, J., & Ahmad, M. (2003). Molecular mechanisms of N-acetylcysteine actions. Cellular and Molecular Life Sciences, 60(1), 6-20.
Zanuy, M., & Carranza, F. (2007). Metabolism, endogenous and exogenous sources of vitamin D. Revista Española de Enfermedades Metabólicas Óseas, 16(4), 63-70.
Zeng, H.-P., Wang, T.-T., Ouyang, X.-H., Zhou, Y.-D., Jing, H.-L., Yuan, G.-Z., … Zhou, J.-H. (2006). 8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs). Bioorganic and Medicinal Chemistry, 14(16), 5446-5450.
Zeng, H.-P., Wang, T.-T., Xu, D.-F., Cai, Y.-P., & Chen, D.-F. (2007). Synthesis, crystal structure and biological activity of 2-[2-(quinolin-2-yl) vinyl]-8-hydroxyquinoline and 2-[2-(quinolin-4-yl) vinyl]-8-hydroxyquinoline. Journal of Applied Crystallography, 40(3), 471-475.
Zeng, W., Xiao, J., Zheng, G., Xing, F., Tipoe, G. L., Wang, X., … Liu, Y. (2015). Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model. Scientific Reports, 5, 11100. https://doi.org/10.1038/srep11100
Zeng, W., Xiao, J., Zheng, G., Xing, F., Tipoe, G. L., Wang, X., … Liu, Y. (2015). Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model. Scientific Reports, 5, 11100.
Zeng, X., Zeng, Y.-S, Ma, Y.-H., Lu, L.-Y., Du, B.-L., Zhang, W., … Chan, W. Y. (2011). Bone marrow mesenchymal stem cells in a three-dimensional gelatin sponge scaffold attenuate inflammation, promote angiogenesis, and reduce cavity formation in experimental spinal cord injury. Cell Transplantation, 20(11-12), 1881-1899.
Zhang, G.-W., Gu, T.-X., Sun, X.-J., Wang, C., Qi, X., Wang, X.-B., & Li-Ling, J. (2016). Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model. The Journal of Thoracic and Cardiovascular Surgery, 152(2), 570-582.
Zhang, L., Zhang, Y., Du, Y., Wang, J., & Chi, L. (2020). Development of curcumin-loaded silk fibroin nanoparticles as drug delivery vehicle for the treatment of ischemic stroke for patients in nursing care in hospitals. Journal of Drug Delivery Science and Technology, 55, 101360.
Zhang, Y., Marsboom, G., Toth, P. T., & Rehman, J. (2013). Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells. PLOS One, 8(10):e77077.
Zhang, Y., Strehin, I., Bedelbaeva, K., Gourevitch, D., Clark, L., Leferovich, J., … Heber-Katz, E. (2015). Drug-induced regeneration in adult mice. Science Translational Medicine, 7(290), 290ra92.
Zhao, J., Gao, W., Cai, X., Xu, J., Zou, D., Li, Z., … Zheng, Y. (2019). Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease. Theranostics, 9(10), 2843-2855.
Zhu, W., Chen, J., Cong, X., Hu, S., & Chen, X. (2006). Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells, 24(2), 416-425.