Enhanced new bone formation in canine maxilla by a graft of electrically polarized β-tricalcium phosphate.
canine
electrical polarization
maxilla
β-tricalcium phosphate (β-TCP)
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
26
12
2019
revised:
03
03
2020
accepted:
19
03
2020
pubmed:
3
4
2020
medline:
5
11
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
We succeeded in the electrical polarization of β-tricalcium phosphate (β-TCP) granules and performed an unprecedented attempt to implant them into maxillary bone defects in canines to confirm their ability to facilitate new bone formation. Two holes were drilled into each maxilla half of a canine and filled with electrically polarized and nonpolarized β-TCP granules (grouping assignment was decided randomly). The implanted specimens were dissected en bloc and used for microcomputed tomography (μCT) observations and histological analyses 4 and 8 weeks after the operation. New bone ingrowth in the bone hole progressed over time from the superficial layer of the cortex toward the inner cancellous bone. The percentage area of new bone in the bone hole, as measured by μCT in the sagittal plane, was significantly larger after 4 and 8 weeks, and that measured by H&E-stained specimens in the transverse plane after 4 weeks was significantly larger in the polarized group than in the nonpolarized group. In addition to the structural stability and chemical characteristics of the β-TCP granules, electrical stimulation bears influence not indirectly but directly on osteogenic and vessel cells, which might work cooperatively for the early initiation of the bone formation process.
Substances chimiques
Bone Substitutes
0
Calcium Phosphates
0
beta-tricalcium phosphate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2820-2826Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
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