Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Animals
Cholestasis
/ genetics
Disease Models, Animal
Female
Liver
/ metabolism
Liver Cirrhosis
/ genetics
Macrophages
/ metabolism
Male
Mice
Mice, Knockout
Receptors, TNF-Related Apoptosis-Inducing Ligand
/ genetics
Signal Transduction
/ physiology
ATP-Binding Cassette Sub-Family B Member 4
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
20
08
2019
revised:
21
01
2020
accepted:
25
02
2020
pubmed:
3
4
2020
medline:
23
6
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic cholestatic liver disease is unclear. Herein, we examined TRAIL receptor signaling in a mouse model of cholestatic liver injury. TRAIL receptor-deficient (Tnsf10 or Tr
Identifiants
pubmed: 32240619
pii: S0002-9440(20)30135-8
doi: 10.1016/j.ajpath.2020.02.013
pmc: PMC7280758
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
Receptors, TNF-Related Apoptosis-Inducing Ligand
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1284-1297Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK084567
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124182
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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