Human organoids to model the developing human neocortex in health and disease.
Neural stem cell
Neurogenesis
Physiology
Radial glia cell
Journal
Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
04
09
2019
revised:
28
01
2020
accepted:
24
03
2020
pubmed:
3
4
2020
medline:
15
9
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
Rodent models have catalyzed major discoveries in the neocortex, a brain region unique to mammals. However, since the neocortex has expanded considerably in primates, employing rodent models has limitations. Human fetal brain tissue is a scarce resource with limitations for experimental manipulations. In order to create an experimentally tractable representation of human brain development, a number of labs have recently created in vitro models of the developing human brain. These models, generated using human embryonic stem cells or induced pluripotent stem cells, are called "organoids". Organoids have successfully and rapidly uncovered new mechanisms of human brain development in health and disease. In the future, we envision that this strategy will enable faster and more efficient translation of basic neuroscience findings to therapeutic applications. In this review, we discuss the generation of the first human cerebral organoids, progress since their debut, and challenges to be overcome in the future.
Identifiants
pubmed: 32240655
pii: S0006-8993(20)30159-1
doi: 10.1016/j.brainres.2020.146803
pmc: PMC7352040
mid: NIHMS1596943
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
146803Subventions
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
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