The in vitro effects of phospholipase D1-mTOR axis in liver fibrogenesis.
Hepatic stellate cells
Liver fibrosis
Phospholipase D1
mTOR
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 Jun 2020
15 Jun 2020
Historique:
received:
23
11
2019
revised:
14
03
2020
accepted:
26
03
2020
pubmed:
3
4
2020
medline:
6
5
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
The activation of hepatic stellate cells (HSCs) plays a central role in liver fibrosis progression. Phospholipase D (PLD) enzymes participate in multiple cellular activities. However, whether and how PLD regulates HSCs activation remain elusive. The expression of intrahepatic PLD1 and PLD2 was determined in CCl Significant increase of PLD1, not PLD2 was documented in CCl The PLD1-mTOR axis of HSCs could be therapeutically targeted in advanced liver fibrosis.
Identifiants
pubmed: 32240681
pii: S0024-3205(20)30343-X
doi: 10.1016/j.lfs.2020.117595
pii:
doi:
Substances chimiques
TOR Serine-Threonine Kinases
EC 2.7.11.1
phospholipase D2
EC 3.1.4.-
Phospholipase D
EC 3.1.4.4
phospholipase D1
EC 3.1.4.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117595Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that there are no conflicts of interest.