A correlational meta-analytical study of transforming growth factor-β genetic polymorphisms as a risk factor for chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease
Meta-analysis
Polymorphism
Risk
Transforming growth factor-β
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
20 Jun 2020
20 Jun 2020
Historique:
received:
10
10
2019
revised:
27
03
2020
accepted:
28
03
2020
pubmed:
3
4
2020
medline:
26
5
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
Several studies have examined the association between transforming growth factor-β (TGF-β) genetic polymorphisms and chronic obstructive pulmonary disease (COPD) risk, but the results remained inconclusive and controversial. We aimed to examine the correlation between TGF-β genetic polymorphisms and COPD risk through a comprehensive meta-analysis. Additionally, changes in circulating TGF-β concentrations across genotypes of TGF-β genetic polymorphisms were analyzed. Literature search, quality assessment, and data extraction were completed independently and in duplicate. Data are expressed in odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). A total of 12 articles, involving 14 independent studies and 7 170 participants, were meta-analyzed for the correlation of five polymorphisms (rs2241712, rs1800469, rs1982073, rs6957, and rs2241718) in TGF-β gene with COPD risk. Under the allele model, no statistical significance was observed for all polymorphisms associated with COPD risk. Subsidiary analyses indicated that country, COPD stage, and diagnosis of COPD were potential sources of between-study heterogeneity. Filled full plots revealed no missing studies for all studied polymorphisms, except rs1982073. Genotype-phenotype analyses showed that carriers of rs1800469 CT genotype had significantly higher concentrations of circulating TGF-β than those with CC genotype in COPD patients (WMD: 0.28 pg/ml, 95% CI: 0.01 to 0.56). Our findings failed to support the candidacy of TGF-β gene in the development of COPD, whereas the contribution of TGF-β gene to COPD might be ethnicity- and stage-dependent.
Sections du résumé
BACKGROUND
BACKGROUND
Several studies have examined the association between transforming growth factor-β (TGF-β) genetic polymorphisms and chronic obstructive pulmonary disease (COPD) risk, but the results remained inconclusive and controversial.
AIMS
OBJECTIVE
We aimed to examine the correlation between TGF-β genetic polymorphisms and COPD risk through a comprehensive meta-analysis. Additionally, changes in circulating TGF-β concentrations across genotypes of TGF-β genetic polymorphisms were analyzed.
METHODS
METHODS
Literature search, quality assessment, and data extraction were completed independently and in duplicate. Data are expressed in odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI).
RESULTS
RESULTS
A total of 12 articles, involving 14 independent studies and 7 170 participants, were meta-analyzed for the correlation of five polymorphisms (rs2241712, rs1800469, rs1982073, rs6957, and rs2241718) in TGF-β gene with COPD risk. Under the allele model, no statistical significance was observed for all polymorphisms associated with COPD risk. Subsidiary analyses indicated that country, COPD stage, and diagnosis of COPD were potential sources of between-study heterogeneity. Filled full plots revealed no missing studies for all studied polymorphisms, except rs1982073. Genotype-phenotype analyses showed that carriers of rs1800469 CT genotype had significantly higher concentrations of circulating TGF-β than those with CC genotype in COPD patients (WMD: 0.28 pg/ml, 95% CI: 0.01 to 0.56).
CONCLUSION
CONCLUSIONS
Our findings failed to support the candidacy of TGF-β gene in the development of COPD, whereas the contribution of TGF-β gene to COPD might be ethnicity- and stage-dependent.
Identifiants
pubmed: 32240778
pii: S0378-1119(20)30302-4
doi: 10.1016/j.gene.2020.144633
pii:
doi:
Substances chimiques
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
144633Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.