Calabadion 1 selectively reverses respiratory and central nervous system effects of fentanyl in a rat model.

Analgesics, Opioid / adverse effects Animals Disease Models, Animal Fentanyl / adverse effects Heterocyclic Compounds, 4 or More Rings / pharmacology Male Nervous System Physiological Phenomena / drug effects Rats Rats, Sprague-Dawley Respiratory Insufficiency / chemically induced Sulfonic Acids / pharmacology
anaesthesia analgesics delayed emergence fentanyl muscle rigidity opioid reversal postoperative complications respiratory depression

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
07 2020
Historique:
received: 27 11 2019
revised: 23 02 2020
accepted: 25 02 2020
pubmed: 4 4 2020
medline: 14 7 2020
entrez: 4 4 2020
Statut: ppublish

Résumé

We hypothesised that Calabadion 1, an acyclic cucurbit[n]uril molecular container, reverses fentanyl-induced respiratory depression and dysfunction of the CNS. Experiments were conducted in male Sprague-Dawley rats. A constant-rate i.v. infusion of fentanyl (12.5 or 25 μg kg Calabadion 1 reversed fentanyl-induced respiratory depression across the endpoints minute ventilation, pH, and Paco Calabadion 1 selectively and dose dependently reversed the respiratory system and CNS side-effects of fentanyl.

Sections du résumé

BACKGROUND
We hypothesised that Calabadion 1, an acyclic cucurbit[n]uril molecular container, reverses fentanyl-induced respiratory depression and dysfunction of the CNS.
METHODS
Experiments were conducted in male Sprague-Dawley rats. A constant-rate i.v. infusion of fentanyl (12.5 or 25 μg kg
RESULTS
Calabadion 1 reversed fentanyl-induced respiratory depression across the endpoints minute ventilation, pH, and Paco
CONCLUSIONS
Calabadion 1 selectively and dose dependently reversed the respiratory system and CNS side-effects of fentanyl.

Identifiants

DOI: 10.1016/j.bja.2020.02.019 PMID: 32241547 PMC: PMC7418560
pubmed: 32241547
pii: S0007-0912(20)30134-3
doi: 10.1016/j.bja.2020.02.019
pmc: PMC7418560
pii:
doi:

Substances chimiques

Analgesics, Opioid 0
Heterocyclic Compounds, 4 or More Rings 0
Sulfonic Acids 0
calabadion 1 0
Fentanyl UF599785JZ

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e140-e147

Subventions

Organisme : NIA NIH HHS
ID : R01 AG053582
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG3 HL140177
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM132345
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA168365
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117871
Pays : United States

Informations de copyright

Copyright © 2020 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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Auteurs

Tharusan Thevathasan (T)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Stephanie D Grabitz (SD)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Peter Santer (P)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Paul Rostin (P)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Oluwaseun Akeju (O)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

James D Boghosian (JD)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Monica Gill (M)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Lyle Isaacs (L)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.

Joseph F Cotten (JF)

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Matthias Eikermann (M)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen, Essen, Germany. Electronic address: meikerma@bidmc.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Eucaryotes › Animaux › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Fentanyl › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Insuffisance respiratoire › Calabadion 1 selectively reverses respiratory...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Calabadion 1 selectively reverses respiratory...