The gut microbiome but not the resistome is associated with urogenital schistosomiasis in preschool-aged children.
Age Factors
Animals
Bacteria
/ classification
Case-Control Studies
Child, Preschool
Cross-Sectional Studies
Female
Gastrointestinal Microbiome
Host-Parasite Interactions
Humans
Infant
Intestines
/ microbiology
Male
Metagenome
Metagenomics
Schistosoma haematobium
/ pathogenicity
Schistosomiasis haematobia
/ diagnosis
Zimbabwe
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
02 04 2020
02 04 2020
Historique:
received:
01
11
2019
accepted:
25
02
2020
entrez:
4
4
2020
pubmed:
4
4
2020
medline:
16
6
2021
Statut:
epublish
Résumé
Helminth parasites have been shown to have systemic effects in the host. Using shotgun metagenomic sequencing, we characterise the gut microbiome and resistome of 113 Zimbabwean preschool-aged children (1-5 years). We test the hypothesis that infection with the human helminth parasite, Schistosoma haematobium, is associated with changes in gut microbial and antimicrobial resistance gene abundance/diversity. Here, we show that bacteria phyla Bacteroidetes, Firmicutes, Proteobacteria, and fungi phyla Ascomycota, Microsporidia, Zoopagomycota dominate the microbiome. The abundance of Proteobacteria, Ascomycota, and Basidiomycota differ between schistosome-infected versus uninfected children. Specifically, infection is associated with increases in Pseudomonas, Stenotrophomonas, Derxia, Thalassospira, Aspergillus, Tricholoma, and Periglandula, with a decrease in Azospirillum. We find 262 AMR genes, from 12 functional drug classes, but no association with individual-specific data. To our knowledge, we describe a novel metagenomic dataset of Zimbabwean preschool-aged children, indicating an association between urogenital schistosome infection and changes in the gut microbiome.
Identifiants
pubmed: 32242065
doi: 10.1038/s42003-020-0859-7
pii: 10.1038/s42003-020-0859-7
pmc: PMC7118151
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
155Subventions
Organisme : Wellcome Trust
ID : 108061/Z/15/Z
Pays : United Kingdom
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