Long-Term Response to a Bioactive Biphasic Biomaterial in the Femoral Neck of Osteoporotic Rats.
femoral neck canal
local delivery
osteoporosis
regenerative medicine
zoledronic acid
Journal
Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
4
4
2020
medline:
24
9
2021
entrez:
4
4
2020
Statut:
ppublish
Résumé
Osteoporosis often leads to fragility fractures of the hip, resulting in impaired quality of life and increased mortality. Augmenting the proximal femur could be an attractive option for prevention of fracture or fixation device failure. We describe a tissue engineering based strategy to enhance long-term bone formation in the femoral neck of osteoporotic rats by locally delivering bioactive molecules; recombinant human bone morphogenic protein-2 (rhBMP-2), and zoledronic acid (ZA) by using a calcium sulfate/hydroxyapatite (CaS/HA) biomaterial. A defect was created by reaming the femoral neck canal of osteoporotic (OVX) rats and they were treated as follows: G1. Empty, G2. CaS/HA, G3. CaS/HA+Systemic ZA, G4. CaS/HA+Local ZA, and G5. CaS/HA+Local ZA+rhBMP-2. Bone formation was evaluated 6 months after treatment. Further, radioactively labeled
Identifiants
pubmed: 32242474
doi: 10.1089/ten.TEA.2020.0018
pmc: PMC7580608
doi:
Substances chimiques
BMP2 protein, human
0
Biocompatible Materials
0
Bone Morphogenetic Protein 2
0
Recombinant Proteins
0
Zoledronic Acid
6XC1PAD3KF
Durapatite
91D9GV0Z28
Calcium Sulfate
WAT0DDB505
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1042-1051Références
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