Replicative fitness recuperation of a recombinant murine norovirus -


Journal

The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340

Informations de publication

Date de publication:
05 2020
Historique:
pubmed: 4 4 2020
medline: 27 10 2020
entrez: 4 4 2020
Statut: ppublish

Résumé

Noroviruses are recognized as the major cause of non-bacterial gastroenteritis in humans. Molecular mechanisms driving norovirus evolution are the accumulation of point mutations and recombination. Recombination can create considerable changes in a viral genome, potentially eliciting a fitness cost, which must be compensated via the adaptive capacity of a recombinant virus. We previously described replicative fitness reduction of the first

Identifiants

pubmed: 32242791
doi: 10.1099/jgv.0.001406
doi:

Substances chimiques

DNA, Complementary 0
RNA, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

510-522

Subventions

Organisme : Wellcome Trust
ID : 207498/Z/17/Z
Pays : United Kingdom

Auteurs

Louisa F Ludwig-Begall (LF)

Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, FARAH Research Centre, Faculty of Veterinary Medicine, Liège University, Liège, Belgium.

Jia Lu (J)

Present address: The Babraham Institute, Babraham Hall House, Babraham, Cambridge, UK.
Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.

Myra Hosmillo (M)

Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.

Edmilson F de Oliveira-Filho (EF)

Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, FARAH Research Centre, Faculty of Veterinary Medicine, Liège University, Liège, Belgium.

Elisabeth Mathijs (E)

Infectious diseases in animals, Sciensano, Ukkel, Belgium.
Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, FARAH Research Centre, Faculty of Veterinary Medicine, Liège University, Liège, Belgium.

Ian Goodfellow (I)

Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.

Axel Mauroy (A)

Staff direction for risk assessment, Control Policy, FASFC, Brussels, Belgium.
Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, FARAH Research Centre, Faculty of Veterinary Medicine, Liège University, Liège, Belgium.

Etienne Thiry (E)

Veterinary Virology and Animal Viral Diseases, Department of Infectious and Parasitic Diseases, FARAH Research Centre, Faculty of Veterinary Medicine, Liège University, Liège, Belgium.

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Classifications MeSH