Replicative fitness recuperation of a recombinant murine norovirus -
Norovirus
evolution
fitness
murine
recombination
reverse genetics
Journal
The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
4
4
2020
medline:
27
10
2020
entrez:
4
4
2020
Statut:
ppublish
Résumé
Noroviruses are recognized as the major cause of non-bacterial gastroenteritis in humans. Molecular mechanisms driving norovirus evolution are the accumulation of point mutations and recombination. Recombination can create considerable changes in a viral genome, potentially eliciting a fitness cost, which must be compensated via the adaptive capacity of a recombinant virus. We previously described replicative fitness reduction of the first
Identifiants
pubmed: 32242791
doi: 10.1099/jgv.0.001406
doi:
Substances chimiques
DNA, Complementary
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
510-522Subventions
Organisme : Wellcome Trust
ID : 207498/Z/17/Z
Pays : United Kingdom