Smooth Muscle Cell Reprogramming in Aortic Aneurysms.

Animals Aorta Aortic Aneurysm Cellular Reprogramming Mice Muscle, Smooth, Vascular Myocytes, Smooth Muscle Transforming Growth Factor beta
TGF-beta aneurysm aorta artificial intelligence atherosclerosis cell fate cell reprogramming mesenchymal stem cell scRNA-seq smooth muscle cells

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
02 04 2020
Historique:
received: 28 07 2018
revised: 27 08 2019
accepted: 21 02 2020
entrez: 4 4 2020
pubmed: 4 4 2020
medline: 28 4 2021
Statut: ppublish

Résumé

The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) signaling in smooth muscle. Here, we investigated the interactions between these different factors in aortic aneurysm development and identified a key role for smooth muscle cell (SMC) reprogramming into a mesenchymal stem cell (MSC)-like state. SMC-specific ablation of TGF-β signaling in Apoe

Identifiants

DOI: 10.1016/j.stem.2020.02.013 PMID: 32243809 PMC: PMC7182079
pubmed: 32243809
pii: S1934-5909(20)30066-7
doi: 10.1016/j.stem.2020.02.013
pmc: PMC7182079
mid: NIHMS1570858
pii:
doi:

Substances chimiques

Transforming Growth Factor beta 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

542-557.e11

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146723
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152197
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL134605
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134712
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL084312
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests J.M.-L., S.G., and T.W.C. are employees of WuxiNextCode. All other authors declare no competing interests.

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Auteurs

Pei-Yu Chen (PY)

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Lingfeng Qin (L)

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Guangxin Li (G)

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA; Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong Province, China.

Jose Malagon-Lopez (J)

Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA; Complex Biological Systems Alliance, Medford, MA, USA.

Zheng Wang (Z)

School of Basic Medicine, Qingdao University, Shandong, China.

Sonia Bergaya (S)

Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, NY, USA.

Sharvari Gujja (S)

Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA; Complex Biological Systems Alliance, Medford, MA, USA.

Alexander W Caulk (AW)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

Sae-Il Murtada (SI)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

Xinbo Zhang (X)

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Zhen W Zhuang (ZW)

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Deepak A Rao (DA)

Division of Rheumatology, Inflammation, Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Guilin Wang (G)

Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.

Zuzana Tobiasova (Z)

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Bo Jiang (B)

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA; Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China.

Ruth R Montgomery (RR)

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Lele Sun (L)

Genomics Laboratory, WuXiNextCODE, Shanghai, China.

Hongye Sun (H)

Genomics Laboratory, WuXiNextCODE, Shanghai, China.

Edward A Fisher (EA)

Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, NY, USA.

Jeffrey R Gulcher (JR)

Cancer Genetics Group, WuXi NextCODE, Cambridge, MA, USA.

Carlos Fernandez-Hernando (C)

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Jay D Humphrey (JD)

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

George Tellides (G)

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA. Electronic address: george.tellides@yale.edu.

Thomas W Chittenden (TW)

Computational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA; Complex Biological Systems Alliance, Medford, MA, USA; Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: tchittenden@wuxinextcode.com.

Michael Simons (M)

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: michael.simons@yale.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladies de l'aorte › Anévrysme de l'aorte › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Smooth Muscle Cell Reprogramming in Aortic Aneurysms.