How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms.
(∗)Insert Keywords Here(∗)
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
02 04 2020
02 04 2020
Historique:
received:
24
09
2019
revised:
13
01
2020
accepted:
09
03
2020
entrez:
4
4
2020
pubmed:
4
4
2020
medline:
23
7
2020
Statut:
ppublish
Résumé
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse. In this review, we take a look at the components of protein-RNA interaction, from the molecular level to multi-component interaction. We first summarize what is known about protein-RNA molecular interactions based on analyses of solved structures. We additionally describe software currently available for predicting protein-RNA interaction and other resources useful for the study of RBPs. We then review the structure and function of seventeen known RNA-binding domains and analyze the hydrogen bonds adopted by protein-RNA structures on a domain-by-domain basis. We conclude with a summary of the higher-level mechanisms that regulate protein-RNA interactions.
Identifiants
pubmed: 32243832
pii: S1097-2765(20)30159-3
doi: 10.1016/j.molcel.2020.03.011
pmc: PMC7202378
mid: NIHMS1580507
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
RNA-Binding Proteins
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-29Subventions
Organisme : NICHD NIH HHS
ID : R01 HD085902
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG004659
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007541
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests G.W.Y. is co-founder, member of the board of directors, equity holder, and paid consultant for Locana and Eclipse BioInnovations. G.W.Y. is a Distinguished Visiting Professor at the National University of Singapore. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. All other authors declare no competing interests.
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